Human germ cell tumours from a developmental perspective

• Published in: Nature reviews. Cancer Vol. 19; no. 9; pp. 522 - 537
• Main Authors: Oosterhuis, J. Wolter, Looijenga, Leendert H. J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2019; Nature Publishing Group
• Subjects: 631/67/1059/2326; 631/67/1678; 631/67/1679; 631/67/1836; Alleles; Animals; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Biomedicine; Cancer Research; Care and treatment; Cell Movement; Disease Progression; DNA damage; Embryogenesis; Embryonic Development; Embryonic growth stage; Epidemiology; Epigenesis, Genetic; Epigenetics; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Genital cancer; Genomic Imprinting; Genomics; Germ cells; Gonads; Humans; Karyotyping; Male; Medical treatment; Mutation; Neoplasms, Germ Cell and Embryonal - genetics; Neoplasms, Germ Cell and Embryonal - metabolism; Ovaries; p53 Protein; Pluripotency; Review Article; Risk factors; Stem cells; Stem Cells - metabolism; Tumors

Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites, where migrating primordial germ cells are located during embryogenesis. This group of heterogeneous neoplasms is unique in t...