Inhibition of human pulpal gelatinases (MMP-2 and MMP-9) by zinc oxide cements
summary The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been implicated in several pathological and physiological processes such as, periodontal tissue destruction, root caries, dentin calcification and...
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| Published in | Journal of oral rehabilitation Vol. 31; no. 7; pp. 660 - 664 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Science Ltd
01.07.2004
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| Subjects | |
| Online Access | Get full text |
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| Abstract | summary The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been implicated in several pathological and physiological processes such as, periodontal tissue destruction, root caries, dentin calcification and pulpal inflammation. The aim of this work was to test the effect of zinc released from zinc oxide–eugenol (ZOE) cements, on the activity of the major pulpal gelatinolytic MMPs. Pulpal explants were cultured overnight in Dulbecco's Modified Eagle Medium and the activity of secreted enzymes was analysed by gelatin zymography in buffer conditionated with diverse ZOE cements. Phenanthroline, a zinc chelator, was used to revert the inhibition of MMPs caused by zinc. The major gelatinolytic proteinases present in the conditioned media were characterized as MMP‐2 and MMP‐9 by immunoprecipitation. All ZOE cements inhibited MMPs activity, whereas phenanthroline could partially revert the inhibition caused by plain ZOE and Intermediate Restorative Material (IRM). |
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| AbstractList | The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been implicated in several pathological and physiological processes such as, periodontal tissue destruction, root caries, dentin calcification and pulpal inflammation. The aim of this work was to test the effect of zinc released from zinc oxide-eugenol (ZOE) cements, on the activity of the major pulpal gelatinolytic MMPs. Pulpal explants were cultured overnight in Dulbecco's Modified Eagle Medium and the activity of secreted enzymes was analysed by gelatin zymography in buffer conditioned with diverse ZOE cements. Phenanthroline, a zinc chelator, was used to revert the inhibition of MMPs caused by zinc. The major gelatinolytic proteinases present in the conditioned media were characterized as MMP-2 and MMP-9 by immunoprecipitation. All ZOE cements inhibited MMPs activity, whereas phenanthroline could partially revert the inhibition caused by plain ZOE and Intermediate Restorative Material (IRM).The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been implicated in several pathological and physiological processes such as, periodontal tissue destruction, root caries, dentin calcification and pulpal inflammation. The aim of this work was to test the effect of zinc released from zinc oxide-eugenol (ZOE) cements, on the activity of the major pulpal gelatinolytic MMPs. Pulpal explants were cultured overnight in Dulbecco's Modified Eagle Medium and the activity of secreted enzymes was analysed by gelatin zymography in buffer conditioned with diverse ZOE cements. Phenanthroline, a zinc chelator, was used to revert the inhibition of MMPs caused by zinc. The major gelatinolytic proteinases present in the conditioned media were characterized as MMP-2 and MMP-9 by immunoprecipitation. All ZOE cements inhibited MMPs activity, whereas phenanthroline could partially revert the inhibition caused by plain ZOE and Intermediate Restorative Material (IRM). summary The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been implicated in several pathological and physiological processes such as, periodontal tissue destruction, root caries, dentin calcification and pulpal inflammation. The aim of this work was to test the effect of zinc released from zinc oxide–eugenol (ZOE) cements, on the activity of the major pulpal gelatinolytic MMPs. Pulpal explants were cultured overnight in Dulbecco's Modified Eagle Medium and the activity of secreted enzymes was analysed by gelatin zymography in buffer conditionated with diverse ZOE cements. Phenanthroline, a zinc chelator, was used to revert the inhibition of MMPs caused by zinc. The major gelatinolytic proteinases present in the conditioned media were characterized as MMP‐2 and MMP‐9 by immunoprecipitation. All ZOE cements inhibited MMPs activity, whereas phenanthroline could partially revert the inhibition caused by plain ZOE and Intermediate Restorative Material (IRM). summary The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been implicated in several pathological and physiological processes such as, periodontal tissue destruction, root caries, dentin calcification and pulpal inflammation. The aim of this work was to test the effect of zinc released from zinc oxide–eugenol (ZOE) cements, on the activity of the major pulpal gelatinolytic MMPs. Pulpal explants were cultured overnight in Dulbecco's Modified Eagle Medium and the activity of secreted enzymes was analysed by gelatin zymography in buffer conditionated with diverse ZOE cements. Phenanthroline, a zinc chelator, was used to revert the inhibition of MMPs caused by zinc. The major gelatinolytic proteinases present in the conditioned media were characterized as MMP‐2 and MMP‐9 by immunoprecipitation. All ZOE cements inhibited MMPs activity, whereas phenanthroline could partially revert the inhibition caused by plain ZOE and Intermediate Restorative Material (IRM). The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been implicated in several pathological and physiological processes such as, periodontal tissue destruction, root caries, dentin calcification and pulpal inflammation. The aim of this work was to test the effect of zinc released from zinc oxide-eugenol (ZOE) cements, on the activity of the major pulpal gelatinolytic MMPs. Pulpal explants were cultured overnight in Dulbecco's Modified Eagle Medium and the activity of secreted enzymes was analysed by gelatin zymography in buffer conditioned with diverse ZOE cements. Phenanthroline, a zinc chelator, was used to revert the inhibition of MMPs caused by zinc. The major gelatinolytic proteinases present in the conditioned media were characterized as MMP-2 and MMP-9 by immunoprecipitation. All ZOE cements inhibited MMPs activity, whereas phenanthroline could partially revert the inhibition caused by plain ZOE and Intermediate Restorative Material (IRM). |
| Author | Trevilatto, P. C. Scarel-Caminaga, R. M. Line, S. R. P. Santos, M. C. L. G. Gerlach, R. F. De Souza, A. P. |
| Author_xml | – sequence: 1 givenname: M. C. L. G. surname: Santos fullname: Santos, M. C. L. G. organization: Department of Morphology, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil – sequence: 2 givenname: A. P. surname: De Souza fullname: De Souza, A. P. organization: Department of Morphology, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil – sequence: 3 givenname: R. F. surname: Gerlach fullname: Gerlach, R. F. organization: Department of Morphology, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil – sequence: 4 givenname: P. C. surname: Trevilatto fullname: Trevilatto, P. C. organization: Department of Morphology, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil – sequence: 5 givenname: R. M. surname: Scarel-Caminaga fullname: Scarel-Caminaga, R. M. organization: Department of Morphology, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil – sequence: 6 givenname: S. R. P. surname: Line fullname: Line, S. R. P. organization: Department of Morphology, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15210026$$D View this record in MEDLINE/PubMed |
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| References_xml | – reference: Creemers LB, Jansen IDC, Docherty AJP, Reynolds JJ, Beertsen W, Everts V. Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue. Matrix Biol. 1998;17: 35-46. – reference: Kawasaki K, Featherstone JDB. Effects of collagenase on root demineralization. J Dent Res. 1997;76: 588-595. – reference: Hanks CT, Wataha JC, Sun Z. In vitro biocompatibility: a review. Dent Mater. 1996;12: 186-193. – reference: Sutinen M, Kainulainen T, Hurskainen T, Vesterlund E, Alexander JP, Overral CM, Sorsa T, Salo T. Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis. Brit J Cancer. 1998;77: 2239-2245. – reference: Ashrafi SH, Waterhouse JP, Baratieri A, Picarelli A, Somma F, Patel M. Use of x-ray microanalysis to monitor diffusion of Zn from a cement into human dentin. J Oral Pathol. 1983;12: 199. – reference: Hanemaaijer R, Sorsa T, Kottinen YT et al. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. J Biol Chem. 1997;272: 31504-31509. – reference: Koch MJ. Formaldehyde release from root-canal sealers: influence of method. Int Endod J. 1999;32: 10-16. – reference: Pitt Ford TR, Andreasen JO, Dorn SO, Kariyawasam SP. Effect of various zinc oxide materials as root-end fillings on healing after implantation. Int Endod J. 1995;28: 273-278. – reference: Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T. In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation. Bone. 1998;22: 33-38. – reference: Fuks AB, Holan G, Davis JM, Eidelman E. Ferric sulfate versus dilute formocresol im pulpotomized primary molars: long term follow up. 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| Snippet | summary The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been... summary The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been... The interaction between metal ions and the oral environment is a major subject matter in dental research. Matrix metalloproteinases (MMPs) have been implicated... |
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| SubjectTerms | Chelating Agents - pharmacology Culture Media, Conditioned Culture Techniques Dental Cements - pharmacology Dental Pulp - enzymology Enzyme Inhibitors - pharmacology Humans Matrix Metalloproteinase Inhibitors matrix metalloproteinase-2 matrix metalloproteinase-9 metalloproteinase Phenanthrolines - pharmacology zinc oxide-eugenol Zinc Oxide-Eugenol Cement - pharmacology |
| Title | Inhibition of human pulpal gelatinases (MMP-2 and MMP-9) by zinc oxide cements |
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