A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection

• Published in: Cell reports (Cambridge) Vol. 22; no. 11; pp. 2951 - 2963
• Main Authors: Zanghì, Gigliola, Vembar, Shruthi S., Baumgarten, Sebastian, Ding, Shuai, Guizetti, Julien, Bryant, Jessica M., Mattei, Denise, Jensen, Anja T.R., Rénia, Laurent, Goh, Yun Shan, Sauerwein, Robert, Hermsen, Cornelus C., Franetich, Jean-François, Bordessoulles, Mallaury, Silvie, Olivier, Soulard, Valérie, Scatton, Olivier, Chen, Patty, Mecheri, Salah, Mazier, Dominique, Scherf, Artur
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 13.03.2018; Elsevier
• Subjects: Animals; epigenetic; hepatocyte infection; Hepatocytes; heterochromatin; Life Sciences; malaria; P. falciparum; PfEMP1; PfHP1; Protozoan Proteins; sporozoite; Sporozoites; var genes; epigenetic; PfHP1; sporozoite; malaria; var genes; hepatocyte infection; PfEMP1; P. falciparum; heterochromatin; P. falciparum

Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and transmission of the malaria parasite Plasmodium falciparum during blood stage infection. Here, we use ChIP sequencing to demonstrate that sporozoites from mosquito salivary glands expand heterochromatin at subte...