The motivation and process for developing a consortium‐wide time and motion study to estimate resource implications of innovations in the use of genome sequencing to inform patient care
Costs of implementing genomic testing innovations extend beyond the cost of sequencing, affecting personnel and infrastructure for which little data are available. We developed a time and motion (T&M) study within the Clinical Sequencing Evidence‐Generating Research (CSER) consortium to address...
Saved in:
Published in | Clinical and translational science Vol. 17; no. 1; pp. e13635 - n/a |
---|---|
Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
John Wiley & Sons, Inc
01.01.2024
John Wiley and Sons Inc Wiley |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Costs of implementing genomic testing innovations extend beyond the cost of sequencing, affecting personnel and infrastructure for which little data are available. We developed a time and motion (T&M) study within the Clinical Sequencing Evidence‐Generating Research (CSER) consortium to address this gap, and herein describe challenges of conducting T&M studies within a research consortium and the approaches we developed to overcome them. CSER investigators created a subgroup to carry out the T&M study (authors). We describe logistical and administrative challenges associated with resource use data collection across heterogeneous projects conducted in real‐world clinical settings, and our solutions for completing this study and harmonizing data across projects. We delineate processes for feasible data collection on workflow, personnel, and resources required to deliver genetic testing innovations in each CSER project. A critical early step involved developing detailed project‐specific process flow diagrams of innovation implementation in projects' clinical settings. Analyzing diagrams across sites, we identified common process‐step themes, used to organize project‐specific data collection and cross‐project analysis. Given the heterogeneity of innovations, study design, and workflows, which affect resources required to deliver genetic testing innovations, flexibility was necessary to harmonize data collection. Despite its challenges, this heterogeneity provides rich insights about variation in clinical processes and resource implications for implementing genetic testing innovations. |
---|---|
AbstractList | Costs of implementing genomic testing innovations extend beyond the cost of sequencing, affecting personnel and infrastructure for which little data are available. We developed a time and motion (T&M) study within the Clinical Sequencing Evidence-Generating Research (CSER) consortium to address this gap, and herein describe challenges of conducting T&M studies within a research consortium and the approaches we developed to overcome them. CSER investigators created a subgroup to carry out the T&M study (authors). We describe logistical and administrative challenges associated with resource use data collection across heterogeneous projects conducted in real-world clinical settings, and our solutions for completing this study and harmonizing data across projects. We delineate processes for feasible data collection on workflow, personnel, and resources required to deliver genetic testing innovations in each CSER project. A critical early step involved developing detailed project-specific process flow diagrams of innovation implementation in projects' clinical settings. Analyzing diagrams across sites, we identified common process-step themes, used to organize project-specific data collection and cross-project analysis. Given the heterogeneity of innovations, study design, and workflows, which affect resources required to deliver genetic testing innovations, flexibility was necessary to harmonize data collection. Despite its challenges, this heterogeneity provides rich insights about variation in clinical processes and resource implications for implementing genetic testing innovations. Abstract Costs of implementing genomic testing innovations extend beyond the cost of sequencing, affecting personnel and infrastructure for which little data are available. We developed a time and motion (T&M) study within the Clinical Sequencing Evidence‐Generating Research (CSER) consortium to address this gap, and herein describe challenges of conducting T&M studies within a research consortium and the approaches we developed to overcome them. CSER investigators created a subgroup to carry out the T&M study (authors). We describe logistical and administrative challenges associated with resource use data collection across heterogeneous projects conducted in real‐world clinical settings, and our solutions for completing this study and harmonizing data across projects. We delineate processes for feasible data collection on workflow, personnel, and resources required to deliver genetic testing innovations in each CSER project. A critical early step involved developing detailed project‐specific process flow diagrams of innovation implementation in projects' clinical settings. Analyzing diagrams across sites, we identified common process‐step themes, used to organize project‐specific data collection and cross‐project analysis. Given the heterogeneity of innovations, study design, and workflows, which affect resources required to deliver genetic testing innovations, flexibility was necessary to harmonize data collection. Despite its challenges, this heterogeneity provides rich insights about variation in clinical processes and resource implications for implementing genetic testing innovations. |
Author | Lynch, Frances L. Finnila, Candice R. Wasserstein, Melissa P. Smith, Hadley S. Kelly, Nicole R. Hoban, Hannah G. Chau, Joanna C. Hindorff, Lucia A. Yip, Tiffany A. Bensen, Jeannette T. Rolf, Bradley A. Hassmiller Lich, Kristen Desrosiers, Lauren R. |
AuthorAffiliation | 7 Center for Health Research Kaiser Permanente Northwest Portland Oregon USA 10 Department of Health Policy and Management University of North Carolina at Chapel Hill Chapel Hill North Carolina USA 3 Department of Epidemiology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA 9 Center for Medical Ethics and Health Policy Baylor College of Medicine Houston Texas USA 1 Institute for Human Genetics University of California San Francisco California USA 5 HudsonAlpha Institute for Biotechnology Huntsville Alabama USA 4 Department of Pediatrics Baylor College of Medicine Houston Texas USA 8 Division of Medical Genetics, Department of Medicine University of Washington Seattle Washington USA 2 Division of Genomic Medicine, National Human Genome Research Institute National Institutes of Health Bethesda Maryland USA 6 Division of Pediatric Genetic Medicine, Department of Pediatrics Children's Hospital at Montefiore and the Albert Einstein College of Medicine Bronx New York USA |
AuthorAffiliation_xml | – name: 3 Department of Epidemiology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA – name: 4 Department of Pediatrics Baylor College of Medicine Houston Texas USA – name: 6 Division of Pediatric Genetic Medicine, Department of Pediatrics Children's Hospital at Montefiore and the Albert Einstein College of Medicine Bronx New York USA – name: 2 Division of Genomic Medicine, National Human Genome Research Institute National Institutes of Health Bethesda Maryland USA – name: 9 Center for Medical Ethics and Health Policy Baylor College of Medicine Houston Texas USA – name: 5 HudsonAlpha Institute for Biotechnology Huntsville Alabama USA – name: 7 Center for Health Research Kaiser Permanente Northwest Portland Oregon USA – name: 1 Institute for Human Genetics University of California San Francisco California USA – name: 8 Division of Medical Genetics, Department of Medicine University of Washington Seattle Washington USA – name: 10 Department of Health Policy and Management University of North Carolina at Chapel Hill Chapel Hill North Carolina USA |
Author_xml | – sequence: 1 givenname: Hannah G. surname: Hoban fullname: Hoban, Hannah G. organization: University of California – sequence: 2 givenname: Tiffany A. surname: Yip fullname: Yip, Tiffany A. organization: University of California – sequence: 3 givenname: Joanna C. surname: Chau fullname: Chau, Joanna C. organization: National Institutes of Health – sequence: 4 givenname: Jeannette T. surname: Bensen fullname: Bensen, Jeannette T. organization: University of North Carolina at Chapel Hill – sequence: 5 givenname: Lauren R. orcidid: 0000-0002-0991-8155 surname: Desrosiers fullname: Desrosiers, Lauren R. organization: Baylor College of Medicine – sequence: 6 givenname: Candice R. surname: Finnila fullname: Finnila, Candice R. organization: HudsonAlpha Institute for Biotechnology – sequence: 7 givenname: Lucia A. surname: Hindorff fullname: Hindorff, Lucia A. organization: National Institutes of Health – sequence: 8 givenname: Nicole R. orcidid: 0000-0003-0349-255X surname: Kelly fullname: Kelly, Nicole R. organization: Children's Hospital at Montefiore and the Albert Einstein College of Medicine – sequence: 9 givenname: Frances L. surname: Lynch fullname: Lynch, Frances L. organization: Kaiser Permanente Northwest – sequence: 10 givenname: Bradley A. orcidid: 0000-0003-2618-7996 surname: Rolf fullname: Rolf, Bradley A. organization: University of Washington – sequence: 11 givenname: Hadley S. orcidid: 0000-0003-1247-6535 surname: Smith fullname: Smith, Hadley S. organization: Baylor College of Medicine – sequence: 12 givenname: Melissa P. surname: Wasserstein fullname: Wasserstein, Melissa P. organization: Children's Hospital at Montefiore and the Albert Einstein College of Medicine – sequence: 13 givenname: Kristen orcidid: 0000-0002-3311-4202 surname: Hassmiller Lich fullname: Hassmiller Lich, Kristen email: klich@unc.edu organization: University of North Carolina at Chapel Hill |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38064200$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kkuO1DAQQCM0iPnAggsgS2xg0TOOEzvJCqEWn5FGYkHvLXel3ONWYgc76VHvOAL34TachOoPLQaJbJK4Xj2Xy3WZnfngMcte5vw6p-cGxnSdF6qQT7KLvJJiVnMlzk7fsjzPLlNac64KVctn2XlBQCk4v8h-Lu6R9WF0GzO64JnxLRtiAEyJ2RBZixvswuD8ihkGwacQRzf1v77_eHAtstH1uM_ZKSg9jVO7ZWNgmChkRmQRU5giIHP90DnY75JYsMx5HzbHX-fZSHVMCXeRFfpA2oTfJvSw25qEzlM5PRsoA_3IwER8nj21pkv44vi-yhYfPyzmn2d3Xz7dzt_fzaCsuJwVFgpRta1UvEGQYCTYSqCxgtZwWQjDm7yosFyqyoJCW3EEsOVSNEuBTXGV3R60bTBrPUQ6V9zqYJzeL4S40oaaAh1qzGVdSqtkY9rSctmAtFDX0IJt6S4Uud4dXMO07LEFOko03SPp44h393oVNjrnlVJcSjK8ORpioP6kUfcuAXad8RimpEXDRaOKpi4Jff0Puqar8NQqovKqbkRe1kS9PVAQQ0oR7amanOvdeGkaL70fL2Jf_V3-ifwzTwTcHIAH1-H2_yY9X3w9KH8DO6jjKg |
Cites_doi | 10.1186/s13012-018-0842-6 10.1016/j.ajhg.2018.08.007 10.1007/s10897-017-0098-3 10.1097/gim.0b013e318182206f 10.1007/s10897-017-0205-5 10.1097/MLR.0b013e31819bc064 10.1080/14737159.2017.1335598 |
ContentType | Journal Article |
Copyright | 2023 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. 2023 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. 2024. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
Copyright_xml | – notice: 2023 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. – notice: 2023 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. – notice: 2024. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
DBID | 24P WIN CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QP 7T5 7TK 7TM 7U9 7X7 7XB 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M7N M7P P64 PIMPY PQEST PQQKQ PQUKI RC3 7X8 5PM DOA |
DOI | 10.1111/cts.13635 |
DatabaseName | Wiley Open Access Wiley Online Library Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student Technology Research Database ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Collection AIDS and Cancer Research Abstracts Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Immunology Abstracts Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database MEDLINE CrossRef |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 24P name: Wiley Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
DocumentTitleAlternate | Consortium‐wide time and motion study for genomics |
EISSN | 1752-8062 |
EndPage | n/a |
ExternalDocumentID | oai_doaj_org_article_e15845f659ad4f059c5fc88cdcfd7526 10_1111_cts_13635 38064200 CTS13635 |
Genre | reviewArticle Journal Article Review |
GeographicLocations | United States--US San Francisco California California |
GeographicLocations_xml | – name: San Francisco California – name: United States--US – name: California |
GrantInformation_xml | – fundername: NHGRI NIH HHS grantid: U01 HG009610 |
GroupedDBID | --- 05W 0R~ 10A 1OC 24P 29B 31~ 4.4 52S 53G 5GY 5VS 7X7 8-1 8FE 8FH 8FI 8FJ AAHHS AAZKR ABDBF ABUWG ACBWZ ACCFJ ACXQS ADKYN ADZMN ADZOD AEEZP AEQDE AFBPY AFKRA AFZJQ AIWBW AJBDE ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AVUZU BBNVY BDRZF BENPR BHPHI BPHCQ BRXPI BVXVI CAG CCPQU COF CS3 DIK EBD EBS EJD EMOBN ESX F5P FEDTE FYUFA G-S GODZA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ IAO IHR KQ8 LH4 LK8 LW6 M7P MY~ O9- OIG OK1 P2P PIMPY PQQKQ PROAC QB0 ROL RPM SUPJJ SV3 TUS UKHRP WIN XG1 CGR CUY CVF ECM EIF ITC NPM AAYXX ACRPL ACYXJ CITATION 3V. 7QP 7T5 7TK 7TM 7U9 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ H94 K9. M7N P64 PQEST PQUKI RC3 7X8 5PM |
ID | FETCH-LOGICAL-c4705-3fc327dd5609ec5ca5cf72eaf2dd5eb32a09137e4b67fc6ef70eccf4b29b2e93 |
IEDL.DBID | RPM |
ISSN | 1752-8054 |
IngestDate | Tue Oct 22 15:07:55 EDT 2024 Tue Sep 17 21:28:56 EDT 2024 Fri Dec 06 00:01:50 EST 2024 Sat Nov 16 11:44:40 EST 2024 Fri Dec 06 05:30:12 EST 2024 Sat Nov 02 12:28:42 EDT 2024 Sat Aug 24 00:54:17 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
License | Attribution-NonCommercial 2023 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c4705-3fc327dd5609ec5ca5cf72eaf2dd5eb32a09137e4b67fc6ef70eccf4b29b2e93 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 |
ORCID | 0000-0003-2618-7996 0000-0003-1247-6535 0000-0002-0991-8155 0000-0003-0349-255X 0000-0002-3311-4202 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766055/ |
PMID | 38064200 |
PQID | 2917892148 |
PQPubID | 2029979 |
PageCount | 11 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_e15845f659ad4f059c5fc88cdcfd7526 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10766055 proquest_miscellaneous_2902963984 proquest_journals_2917892148 crossref_primary_10_1111_cts_13635 pubmed_primary_38064200 wiley_primary_10_1111_cts_13635_CTS13635 |
PublicationCentury | 2000 |
PublicationDate | January 2024 |
PublicationDateYYYYMMDD | 2024-01-01 |
PublicationDate_xml | – month: 01 year: 2024 text: January 2024 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Hoboken |
PublicationTitle | Clinical and translational science |
PublicationTitleAlternate | Clin Transl Sci |
PublicationYear | 2024 |
Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
References | 2009; 47 2008; 10 2017; 26 2017; 17 2018; 27 1995; 56 2018; 103 2001; 10 2019; 14 e_1_2_8_3_1 Lawrence WF (e_1_2_8_7_1) 2001; 10 e_1_2_8_2_1 e_1_2_8_4_1 e_1_2_8_6_1 Surh LC (e_1_2_8_5_1) 1995; 56 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_10_1 e_1_2_8_11_1 |
References_xml | – volume: 103 start-page: 319 issue: 3 year: 2018 end-page: 327 article-title: The clinical sequencing evidence‐generating research consortium: integrating genomic sequencing in diverse and medically underserved populations publication-title: Am J Hum Genet – volume: 10 start-page: 475 issue: 5 year: 2001 end-page: 481 article-title: Cost of genetic counseling and testing for BRCA1 and BRCA2 breast cancer susceptibility mutations publication-title: Cancer Epidemiol Biomarkers Prev – volume: 26 start-page: 657 issue: 4 year: 2017 end-page: 668 article-title: Development of a streamlined work flow for handling Patients' genetic testing insurance authorizations publication-title: J Genet Couns – volume: 27 start-page: 823 issue: 4 year: 2018 end-page: 833 article-title: Time costs for genetic counseling in preconception carrier screening with genome sequencing publication-title: J Genet Couns – volume: 17 start-page: 739 issue: 8 year: 2017 end-page: 750 article-title: The role of genetic testing in epilepsy diagnosis and management publication-title: Expert Rev Mol Diagn – volume: 10 start-page: 699 issue: 9 year: 2008 end-page: 706 article-title: Clinical genetics provider real‐time workflow study publication-title: Genet Med – volume: 14 start-page: 1 issue: 1 year: 2019 end-page: 16 article-title: Systematic review of the exploration, preparation, implementation, sustainment (EPIS) framework publication-title: Implement Sci – volume: 56 start-page: 760 issue: 3 year: 1995 end-page: 768 article-title: Delivery of molecular genetic services within a health care system: time analysis of the clinical workload. The molecular genetic study group publication-title: Am J Hum Genet – volume: 47 start-page: S76 issue: S1 year: 2009 end-page: S81 article-title: Micro‐costing quantity data collection methods publication-title: Med Care – ident: e_1_2_8_9_1 doi: 10.1186/s13012-018-0842-6 – ident: e_1_2_8_10_1 – ident: e_1_2_8_6_1 doi: 10.1016/j.ajhg.2018.08.007 – ident: e_1_2_8_11_1 doi: 10.1007/s10897-017-0098-3 – ident: e_1_2_8_3_1 doi: 10.1097/gim.0b013e318182206f – ident: e_1_2_8_2_1 doi: 10.1007/s10897-017-0205-5 – volume: 56 start-page: 760 issue: 3 year: 1995 ident: e_1_2_8_5_1 article-title: Delivery of molecular genetic services within a health care system: time analysis of the clinical workload. The molecular genetic study group publication-title: Am J Hum Genet contributor: fullname: Surh LC – volume: 10 start-page: 475 issue: 5 year: 2001 ident: e_1_2_8_7_1 article-title: Cost of genetic counseling and testing for BRCA1 and BRCA2 breast cancer susceptibility mutations publication-title: Cancer Epidemiol Biomarkers Prev contributor: fullname: Lawrence WF – ident: e_1_2_8_8_1 doi: 10.1097/MLR.0b013e31819bc064 – ident: e_1_2_8_4_1 doi: 10.1080/14737159.2017.1335598 |
SSID | ssj0063685 |
Score | 2.358819 |
SecondaryResourceType | review_article |
Snippet | Costs of implementing genomic testing innovations extend beyond the cost of sequencing, affecting personnel and infrastructure for which little data are... Abstract Costs of implementing genomic testing innovations extend beyond the cost of sequencing, affecting personnel and infrastructure for which little data... |
SourceID | doaj pubmedcentral proquest crossref pubmed wiley |
SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
StartPage | e13635 |
SubjectTerms | Clinical medicine Consortia Cost estimates Data collection Genetic counseling Genetic screening Genetic Testing Genetics Genomes Humans Innovations Medicine Mini Review Mini Reviews Motivation Patient Care Patients Pediatrics Personnel Time and Motion Studies |
SummonAdditionalLinks | – databaseName: Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELZQD4gL4p9AWw2IA5eI1HHi-EirVhVSubBIvUX-FTk0WzW74soj8D68DU_CjO1NdwWIC7codhLHM46_Lx5_w9gbL4WpXCdKU-mqFNyIsrOSFly5QbTBlYvbxy4-tuefxYfL5nIr1RfFhCV54NRx7_wRTpFNaBulnQgIBixFHXXW2eBkw5PYdsU3ZCp9g1uSVY9bIRsc74hKsqYQxfDY1USxXTG_2-1MFAX7_4Qyfw-W3AaxcRY6e8DuZ_gI71OzH7I7fnzE7l7kBfLH7AeaHa7mnGWgRwfXaS8AIDyF2z1SoAGp8IToe1hf_fz2_evgPFCm-XhNSu4DUXwWVksgLQ7Eth5u8u9-GLZC0WEZYJjTq054DIgrYT15KiEZWLxtDtqmR-MNk2ArZFlXoAC0J2xxdro4OS9zfobSCkkL6MHWXDqHoEl521jd2CC514HjOSTpXJPoqPTCtDLY1gdZocMEYbgy3Kv6Kdsbl6N_zsDUwXFpj0hPULTCK2k0l0bWtrNCybpgrzem6q-TCke_YS9ozz7as2DHZMS5AglnxxPoTn12p_5f7lSw_Y0L9Hk0Tz1HTtspjsyxYK_mYhyHtLiiR79cU52K48dMdaJgz5LHzC2pO6J5VVWwbseXdpq6WzIOX6LWN7LzFhknvtzb6HZ_f_3-ZPEpHrz4H_3wkt3jCN_Sz6Z9tre6WfsDhF8rcxhH2i-OdTNL priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagSIgL4t20BQ2IA5eIrOPEyQmViqpCKhcWaW-Rn5BDk2Wzq_62_rvOON5sVzxuUZyHrZmxv_GMv2HsvZNCZ7YSqc5UlgquRVoZSQFXrhFt8NqG42OX38qLH-LroljEDbchplVu58QwUdve0B75R45-RVVzRO-flr9TqhpF0dVYQuM-ezDjuJSjPsvF5HCVRK4eDkQWaPWITSKzEGXymPVAGV6hyttuPQq0_X_Dmn-mTN6FsmEtOn_CHkcQCaej1J-ye657xh5exjD5c3aDwoerqXIZqM7CcjwRAAhSYXdSChSgQzwgBm83V-l1ax1QtfnwxljgBwIBLax7ID4OxLcOVnHLH9o76ejQe2inEqsDXgNiS9gMjlqIChY_GxO36cf4wZG0FSK1K1AS2gs2P_8yP7tIY42G1AhJQXRvci6tReBUO1MYVRgvuVOe4z101Lki4lHphC6lN6XzMkOl8ULzWnNX5y_ZQdd37pCBzr3l0syIU1CUwtVSKy61zE1lRC3zhL3bCqpZjkwczdaDQWk2QZoJ-0winB4g8uxwo1_9bKItNm6GqKvwZVErKzziS0OJbJWxxltUlTJhJ1sFaKJFD81O_xL2dmpGW6QAi-pcv6FnMo4TWl2JhL0a9WXqSV6Rq5dlCav2NGmvq_stXfsr8H2jh16i14mD-xCU7t_Db87m38PF0f-HcMwecQRn41bSCTtYrzbuNYKrtX4TLOgW96Moag priority: 102 providerName: ProQuest – databaseName: Wiley Open Access dbid: 24P link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3NitRAEC7WFcSL-L_RVUrx4CWQ7XTSCZ50cVmEFcER9hb6V-ewyTKZwes-wr6Pb-OTWNX5cQYVvIV0p5NQVd1fdVd9BfDKK2kyV8nUZDpLpTAyraziA1dhCG2I2sX0sbOP5ekX-eG8ON-DN1MuzMAPMW-4sWXE-ZoNXJt-y8jtuucYrby4ATcJ1pRcvkDIT9M0XDKzesyGLMjkCZiMtEIcxjM_urMYRc7-vwHNP-Mlt3FsXIhO7sKdEUHi20Hk92DPt_fh1tl4Rv4AfpDk8WIuW4a6dXg5pAMgIVT8nSaFGskb7gmALzcXP6-uvy-dRy42H58Z6vtg5J_FdYdMx0Hw1uNq3PHH5VY0OnYBl3OF1Z6ukaAlbnrPLcwES8OOcdv8ahpw4GzFkdkVOQbtISxO3i-OT9OxRENqpeIz9GBzoZwj3FR7W1hd2KCE10HQPfLThWbeUeWlKVWwpQ8qI50J0ojaCF_nj2C_7Vp_AGjy4ISyR0wpKEvpa2W0UEbltrKyVnkCLydRNZcDEUczOTAkzybKM4F3LMS5A3Nnxxvd6mszmmLjjwh0FaEsau1kIHhpOY6tss4GR8pSJnA4qUAzGnTfCHJrq1qQ85jAi7mZTJHPV3Truw33yQTNZ3UlE3g8aMz8JXnFnl6WJVDt6NLOp-62tMtvke6bHPSSnE76uddR7f79-83x4nO8ePL_XZ_CbUE4bdhVOoT99WrjnxHOWpvn0Z5-ASY-KlI priority: 102 providerName: Wiley-Blackwell |
Title | The motivation and process for developing a consortium‐wide time and motion study to estimate resource implications of innovations in the use of genome sequencing to inform patient care |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcts.13635 https://www.ncbi.nlm.nih.gov/pubmed/38064200 https://www.proquest.com/docview/2917892148 https://search.proquest.com/docview/2902963984 https://pubmed.ncbi.nlm.nih.gov/PMC10766055 https://doaj.org/article/e15845f659ad4f059c5fc88cdcfd7526 |
Volume | 17 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NjtMwEB5tFwlxQfyTZakGxIFLt13HiZMjW-1qhdRVBUXqLYodGyLRtGpa7ZVH4H14G56EGScprYALlyqK08TRjONv7G--AXhjldSjIpEDPcpHAym0HCRG8Yar0IQ2RFr49LHJTXz9Sb6fR_MjiLtcGE_aN7o8q74uzqryi-dWrhZm2PHEhtPJmEKWmGB4NOxBj-bfLkZvvr8xS6r7NMiIxjohklZPiPk7ZlMzryvkejVhwtibM9v2JiSv2_83sPknZ3Ify_rJ6OoB3G9RJL5revsQjmz1CO5O2n3yx_CDrI-LXekyzKsCV01KABJKxd-pUpgjRcQ1gfByu_j57fttWVjkgvP-P02NH_QatLhZIktyEMS1uG5X_bHcY6Tj0mG5q7Ja0zESvMRtbbmF1WDpti13mx9NN2x0W7FVd0XmoT2B2dXlbHw9aMs0DIxUvI_uTChUURB2Sq2JTB4Zp4TNnaBzFKuLnLVHlZU6Vs7E1qkR-Y2TWqRa2DR8CsfVsrLPAXXoCqHMOcsKyljaVOlcKK1CkxiZqjCA152pslUjxpF1QQyZNvOmDeCCjbi7gPWz_Ynl-nPWelFmzwl4RS6O0ryQjiCmYS5bYgrjCvKbOIDTzgWydlDXmaDQNkkFBZABvNo103DkPZa8ssstXzMS9E1LExnAs8Zjdj3pPC6A5MCXDrp62EIjwEt-dx4fwFvvdv9-_Ww8--gPTv7_KS_gniDs1qw0ncLxZr21Lwl7bXQfekJO6VfNVR_uXFzeTD_0_TpG3w_CX67PN78 |
link.rule.ids | 230,314,727,780,784,864,885,2102,11562,12056,21388,27924,27925,31719,31720,33744,33745,43310,43805,46052,46476,50814,50923,53791,53793,73745,74302 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZgKwGXimcJFBgQBy4RqdeJkxOiVasFuisEi9RbFL9gD02Wza762_h3zDhOtiset8hOnFgz43zjGX_D2GsrhUpMLmKVVEksuBJxriUFXLlCtMEL44-PTWfZ5Jv4eJFehA23NqRV9muiX6hNo2mP_C1HvyIvOKL3d8ufMVWNouhqKKFxk-0Rc3o6YnvHp7PPX_q1OCN6dX8kMkW7R3QSuIUol0evW8rx8nXetn8kT9z_N7T5Z9LkdTDr_0Znd9l-gJHwvpP7PXbD1vfZrWkIlD9gv1D8cDnULoOqNrDszgQAwlTYnpWCCtAlbhGFLzaX8dXCWKB68_6JrsQPeApaWDdAjByIcC2swqY_LK4lpEPjYDEUWW3xGhBdwqa11ENksDhsSN2mF-OAHW0rBHJXoDS0h2x-djo_mcShSkOshaQwutNjLo1B6FRYneoq1U5yWzmObeiq84qoR6UVKpNOZ9bJBNXGCcULxW0xfsRGdVPbxwzU2Bku9RGxCopM2EKqikslxzrXopDjiL3qBVUuOy6OsvdhUJqll2bEjkmEww1En-0bmtX3MlhjaY8Qd6UuS4vKCIcIU1MqW66NdgZVJYvYYa8AZbDpttxqYMReDt1ojRRiqWrbbOiehOOSVuQiYgedvgxfggqKzl6SRCzf0aSdT93tqRc_POM3-ugZ-p04uTde6f49_fJk_tVfPPn_FF6w25P59Lw8_zD79JTd4QjVuo2lQzZarzb2GUKttXoe7Ok3BZkswA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZgK1VcEO-mLTAgDlyipo4TJydES1fl0VUFi9RbFL8ghybLZlf8Nv4dM453tysetyjOy_KM_U3m8zeMvbJSqMQUIlZJncSCKxEXWlLClStEG7w0fvvYxSQ__yo-XGVXgf_UB1rlak70E7XpNP0jP-IYVxQlR_R-5AIt4vLd-M3sR0wVpCjTGspp3GY7uComfMR2Ts4ml59X83JOUut-e2SGcwAilaAzRLweveiJ7-Vrvm1WJy_i_zfk-SeB8iaw9SvT-B67GyAlvB1s4D67ZdsHbPciJM0fsl9oCnC9rmMGdWtgNuwPAISssNk3BTVgeNwjIm-W1_HPxlig2vP-jqHcD3g5Wlh0QOociHYtzEMCAJob5HToHDTrgqs9HgMiTVj2llpIGBYfG2jc9GJ84CDhCkHoFYiS9ohNx2fT0_M4VGyItZCUUnc65dIYhFGl1ZmuM-0kt7XjeA7Ddl6TDKm0QuXS6dw6maAJOaF4qbgt08ds1Hat3WOgUme41MekMChyYUupai6VTHWhRSnTiL1cDVQ1G3Q5qlU8g6NZ-dGM2AkN4foCktL2J7r5typ4ZmWPEYNlLs_K2giHaFMTra3QRjuDppJH7HBlAFXw777aWGPEXqyb0TMp3VK3tlvSNQnH6a0sRMSeDPay_pK0oMAvSSJWbFnS1qdut7TNd6_-jfF6jjEodu61N7p_d786nX7xB_v_78JztouuVH16P_l4wO5wRG3DP6ZDNlrMl_Ypoq6Fehbc6TfWnDDt |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+motivation+and+process+for+developing+a+consortium-wide+time+and+motion+study+to+estimate+resource+implications+of+innovations+in+the+use+of+genome+sequencing+to+inform+patient+care&rft.jtitle=Clinical+and+translational+science&rft.au=Hoban%2C+Hannah+G&rft.au=Yip%2C+Tiffany+A&rft.au=Chau%2C+Joanna+C&rft.au=Bensen%2C+Jeannette+T&rft.date=2024-01-01&rft.eissn=1752-8062&rft.volume=17&rft.issue=1&rft.spage=e13635&rft_id=info:doi/10.1111%2Fcts.13635&rft_id=info%3Apmid%2F38064200&rft.externalDocID=38064200 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1752-8054&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1752-8054&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1752-8054&client=summon |