Evaluation of drug–drug interactions of a novel potent FLT3 inhibitor SKLB1028 in healthy subjects - Chen, Jingcheng; Wu, Jingxuan; Guo, Nini; Song, Yuqin; Li, Lijun; Wang, Bingyan; Li, Jiangshuo; Hou, Mengyu; Yin, Hang; Zhang, Meijuan; Kong, Yanhong; Wu, Xiaofang; et al. (Clinical and translational science, 2024)
Keywords: Acute myeloid leukemia; Adult; Aniline Compounds; Antifungal agents; Area Under Curve; Clinical significance; Cytochrome P-450 CYP2C8 Inhibitors - administration & dosage; Cytochrome P-450 CYP2C8 Inhibitors - pharmacokinetics; Cytochrome P-450 CYP2C8 Inhibitors - pharmacology; Cytochrome P-450 CYP3A Inducers - administration & dosage; Cytochrome P-450 CYP3A Inducers - pharmacology; Cytochrome P-450 CYP3A Inhibitors - administration & dosage; Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics; Cytochrome P-450 CYP3A Inhibitors - pharmacology; Drug dosages; Drug interaction; Drug Interactions; Drug metabolism; Drug therapy; Electrocardiography; Enzymes; fms-Like Tyrosine Kinase 3 - antagonists & inhibitors; fms-Like Tyrosine Kinase 3 - metabolism; Gemfibrozil; Gemfibrozil - administration & dosage; Gemfibrozil - pharmacokinetics; Gemfibrozil - pharmacology; Healthy Volunteers; Humans; Itraconazole; Itraconazole - administration & dosage; Itraconazole - pharmacokinetics; Itraconazole - pharmacology; Kinases; Leukemia; Male; Medical prognosis; Mutation; Pharmacokinetics; Prescription drugs; Protein Kinase Inhibitors - administration & dosage; Protein Kinase Inhibitors - pharmacokinetics; Protein Kinase Inhibitors - pharmacology; Protein turnover; Pyrazines - administration & dosage; Pyrazines - pharmacokinetics; Pyrazines - pharmacology; Rifampin; Rifampin - administration & dosage; Rifampin - pharmacokinetics; Rifampin - pharmacology; Sample size; Software; Vital signs; Young Adult