An atlas of bacterial secondary metabolite biosynthesis gene clusters

• Published in: Environmental microbiology Vol. 23; no. 11; pp. 6981 - 6992
• Main Authors: Wei, Bin, Du, Ao‐Qi, Zhou, Zhen‐Yi, Lai, Cong, Yu, Wen‐Chao, Yu, Jin‐Biao, Yu, Yan‐Lei, Chen, Jian‐Wei, Zhang, Hua‐Wei, Xu, Xue‐Wei, Wang, Hong
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2021; Wiley Subscription Services, Inc
• Subjects: Actinosynnema; Archangium; Ascomycota - genetics; Bacteria; Biosynthesis; Biosynthetic Pathways - genetics; Comparative analysis; computer software; Cyanobacteria - genetics; Cystobacter; Gene clusters; Genetic diversity; Genetic variation; Genomes; Kibdelosporangium; Kitasatospora; Kutzneria; ligases; Metabolism; Metabolites; Microbiological strains; Moorea; Multigene Family; Natural products; Nocardia; nonribosomal peptides; Polyketides; Programming languages; Saccharothrix; Secondary Metabolism - genetics; Secondary metabolites; Strains (organisms)

Summary Bacterial secondary metabolites are rich sources of novel drug leads. The diversity of secondary metabolite biosynthetic gene clusters (BGCs) in genome‐sequenced bacteria, which will provide crucial information for the efficient discovery of novel natural products, has not been systematicall...