Adaptive Modifications of Hypotheses After an Interim Analysis

• Published in: Biometrical journal Vol. 43; no. 5; pp. 581 - 589
• Main Author: Hommel, Gerhard
• Format: Journal Article
• Language: English
• Published: Berlin WILEY-VCH Verlag Berlin GmbH 01.09.2001; WILEY‐VCH Verlag Berlin GmbH; Wiley-VCH
• Subjects: Adaptive designs; Closure test; Combination tests; Conditional error function; Control of multiple level; Exact sciences and technology; Experimental design; Interim analysis; Mathematics; Multivariate analysis; Nonparametric inference; p-values; Probability and statistics; Sciences and techniques of general use; Statistics; Two-stage designs; Design; Hypothesis test; Weighting; Error estimation; Optimal control; Error function; Error rate; Clinical trial; Planning; Mean value; Adaptive method; Multilevel system

It is investigated how one can modify hypotheses in a trial after an interim analysis such that the type I error rate is controlled. If only a global statement is desired, a solution was given by Bauer (1989). For a general multiple testing problem, Kieser, Bauer and Lehmacher (1999) and Bauer and K...