Clinical Prediction of Functional Outcome After Ischemic Stroke: The Surprising Importance of Periventricular White Matter Disease and Race

• Published in: Stroke (1970) Vol. 40; no. 2; pp. 530 - 536
• Main Authors: Kissela, Brett, Lindsell, Christopher J., Kleindorfer, Dawn, Alwell, Kathleen, Moomaw, Charles J., Woo, Daniel, Flaherty, Matthew L., Air, Ellen, Broderick, Joseph, Tsevat, Joel
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.02.2009; Lippincott Williams & Wilkins
• Subjects: Aged; Algorithms; Biological and medical sciences; Black People; Brain - pathology; Brain Diseases - pathology; Cohort Studies; Comorbidity; Ethnicity; Female; Follow-Up Studies; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Logistic Models; Male; Medical sciences; Middle Aged; Models, Statistical; Nervous system (semeiology, syndromes); Neurology; Prospective Studies; Socioeconomic Factors; Stroke - mortality; Stroke - pathology; Stroke Rehabilitation; Treatment Outcome; Vascular diseases and vascular malformations of the nervous system; White People; predicted models; Cerebral infarction; models; Stroke; Nervous system diseases; Prognosis; Cardiovascular disease; White matter; Cerebral disorder; Vascular disease; white matter disease; outcomes; Central nervous system disease; Race; Brain ischemia; Cerebrovascular disease; ischemic stroke
• ISSN: 0039-2499; 1524-4628; 1524-4628
• DOI: 10.1161/STROKEAHA.108.521906

BACKGROUND AND PURPOSE—We sought to build models that address questions of interest to patients and families by predicting short- and long-term mortality and functional outcome after ischemic stroke, while allowing for risk restratification as comorbid events accumulate. METHODS—A cohort of 451 isch...