Novel Alginate-Chitosan Composite Microspheres for Implant Delivery of Vancomycin and In Vivo Evaluation

• Published in: Chemical biology & drug design Vol. 88; no. 3; pp. 434 - 440
• Main Authors: Mao, Yimin, Zhao, Ming, Ge, Yongbiao, Fan, Jiang
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2016
• Subjects: alginate-chitosan composite microspheres; Alginates - chemistry; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Chitosan - chemistry; Chromatography, High Pressure Liquid; Drug Implants; Female; Glucuronic Acid - chemistry; Hexuronic Acids - chemistry; in vitro release; Male; Microscopy, Electron, Scanning; Microspheres; pharmacokinetics; Rabbits; vancomycin; Vancomycin - administration & dosage; Vancomycin - pharmacokinetics; pharmacokinetics; vancomycin; alginate-chitosan composite microspheres; in vitro release

In this study, vancomycin loaded alginate–chitosan composite microspheres were developed by emulsion cross‐linking method. The in vitro and vivo characterizations were done to evaluate the feasibility of application. Our experimental results showed that the emulsification cross‐linking technique app...