Novel Alginate-Chitosan Composite Microspheres for Implant Delivery of Vancomycin and In Vivo Evaluation
In this study, vancomycin loaded alginate–chitosan composite microspheres were developed by emulsion cross‐linking method. The in vitro and vivo characterizations were done to evaluate the feasibility of application. Our experimental results showed that the emulsification cross‐linking technique app...
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Published in | Chemical biology & drug design Vol. 88; no. 3; pp. 434 - 440 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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England
Blackwell Publishing Ltd
01.09.2016
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Abstract | In this study, vancomycin loaded alginate–chitosan composite microspheres were developed by emulsion cross‐linking method. The in vitro and vivo characterizations were done to evaluate the feasibility of application. Our experimental results showed that the emulsification cross‐linking technique appeared to be a feasible method for the preparation of alginate–chitosan composite microspheres. The microspheres were spherical in shape and the mean particle size and drug loading were 25.3 ± 5.4 μm and 18.5 ± 2.3% respectively. A sustained vancomycin release was realized i.e. the amount of cumulative release increased in a time frame of 24 h to reach an amount i.e. ~68%. The model that fit best for vancomycin released from the microspheres was the Higuchi kinetic model with a correlation coefficient r = 0.9996. In vivo results showed that the application of microspheres not only reduced the toxicity, but also maintained effective drug concentration. In addition, no severe signs of epithelial necrosis and sloughing of epithelial cells were detected in histological studies.
Vancomycin loaded alginate–chitosan composite microspheres were developed by emulsion cross‐linking method. The microspheres were spherical in shape and the mean particle size and drug loading were 25.3 ± 5.4 µm and 18.5 ± 2.3%. In vivo results showed that the application of microspheres not only reduced the toxicity, but also maintained effective drug concentration. |
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AbstractList | In this study, vancomycin loaded alginate-chitosan composite microspheres were developed by emulsion cross-linking method. The in vitro and vivo characterizations were done to evaluate the feasibility of application. Our experimental results showed that the emulsification cross-linking technique appeared to be a feasible method for the preparation of alginate-chitosan composite microspheres. The microspheres were spherical in shape and the mean particle size and drug loading were 25.3 ± 5.4 μm and 18.5 ± 2.3% respectively. A sustained vancomycin release was realized i.e. the amount of cumulative release increased in a time frame of 24 h to reach an amount i.e. ~68%. The model that fit best for vancomycin released from the microspheres was the Higuchi kinetic model with a correlation coefficient r = 0.9996. In vivo results showed that the application of microspheres not only reduced the toxicity, but also maintained effective drug concentration. In addition, no severe signs of epithelial necrosis and sloughing of epithelial cells were detected in histological studies. In this study, vancomycin loaded alginate–chitosan composite microspheres were developed by emulsion cross‐linking method. The in vitro and vivo characterizations were done to evaluate the feasibility of application. Our experimental results showed that the emulsification cross‐linking technique appeared to be a feasible method for the preparation of alginate–chitosan composite microspheres. The microspheres were spherical in shape and the mean particle size and drug loading were 25.3 ± 5.4 μ m and 18.5 ± 2.3% respectively. A sustained vancomycin release was realized i.e. the amount of cumulative release increased in a time frame of 24 h to reach an amount i.e. ~68%. The model that fit best for vancomycin released from the microspheres was the Higuchi kinetic model with a correlation coefficient r = 0.9996. In vivo results showed that the application of microspheres not only reduced the toxicity, but also maintained effective drug concentration. In addition, no severe signs of epithelial necrosis and sloughing of epithelial cells were detected in histological studies. In this study, vancomycin loaded alginate–chitosan composite microspheres were developed by emulsion cross‐linking method. The in vitro and vivo characterizations were done to evaluate the feasibility of application. Our experimental results showed that the emulsification cross‐linking technique appeared to be a feasible method for the preparation of alginate–chitosan composite microspheres. The microspheres were spherical in shape and the mean particle size and drug loading were 25.3 ± 5.4 μm and 18.5 ± 2.3% respectively. A sustained vancomycin release was realized i.e. the amount of cumulative release increased in a time frame of 24 h to reach an amount i.e. ~68%. The model that fit best for vancomycin released from the microspheres was the Higuchi kinetic model with a correlation coefficient r = 0.9996. In vivo results showed that the application of microspheres not only reduced the toxicity, but also maintained effective drug concentration. In addition, no severe signs of epithelial necrosis and sloughing of epithelial cells were detected in histological studies. Vancomycin loaded alginate–chitosan composite microspheres were developed by emulsion cross‐linking method. The microspheres were spherical in shape and the mean particle size and drug loading were 25.3 ± 5.4 µm and 18.5 ± 2.3%. In vivo results showed that the application of microspheres not only reduced the toxicity, but also maintained effective drug concentration. In this study, vancomycin loaded alginate-chitosan composite microspheres were developed by emulsion cross-linking method. The in vitro and vivo characterizations were done to evaluate the feasibility of application. Our experimental results showed that the emulsification cross-linking technique appeared to be a feasible method for the preparation of alginate-chitosan composite microspheres. The microspheres were spherical in shape and the mean particle size and drug loading were 25.3 plus or minus 5.4 mu m and 18.5 plus or minus 2.3% respectively. A sustained vancomycin release was realized i.e. the amount of cumulative release increased in a time frame of 24 h to reach an amount i.e. ~68%. The model that fit best for vancomycin released from the microspheres was the Higuchi kinetic model with a correlation coefficient r = 0.9996. In vivo results showed that the application of microspheres not only reduced the toxicity, but also maintained effective drug concentration. In addition, no severe signs of epithelial necrosis and sloughing of epithelial cells were detected in histological studies. Vancomycin loaded alginate-chitosan composite microspheres were developed by emulsion cross-linking method. The microspheres were spherical in shape and the mean particle size and drug loading were 25.3 plus or minus 5.4 mu m and 18.5 plus or minus 2.3%. In vivo results showed that the application of microspheres not only reduced the toxicity, but also maintained effective drug concentration. |
Author | Ge, Yongbiao Fan, Jiang Zhao, Ming Mao, Yimin |
Author_xml | – sequence: 1 givenname: Yimin surname: Mao fullname: Mao, Yimin organization: Department of Thoracic Surgery, Xiaoshan Hospital of Traditional Chinese Medicine, 156 Yu Cai Road, Xiaoshan District, Hangzhou 311201, China – sequence: 2 givenname: Ming surname: Zhao fullname: Zhao, Ming organization: Department of Thoracic Surgery, Huai'an First People's Hospital, 6 Beijing west Road Huai'an, Jiangsu 223300, China – sequence: 3 givenname: Yongbiao surname: Ge fullname: Ge, Yongbiao organization: Department of Thoracic Surgery, Ninghai First People's Hospital, 6 Taoyuan middle Road, Ninghai 315600, China – sequence: 4 givenname: Jiang surname: Fan fullname: Fan, Jiang email: drjiangfan@163.com organization: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Yangpu, Shanghai 200433, China |
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Cites_doi | 10.1002/jbm.a.34617 10.1016/j.bjid.2013.12.005 10.2147/IJN.S78675 10.1016/j.biomaterials.2011.11.052 10.1016/j.ejpb.2010.09.016 10.1007/s00417-015-3007-1 10.1097/CNQ.0000000000000056 10.2106/JBJS.L.01750 10.1002/jor.22760 10.1111/j.1365-2710.2004.00572.x 10.1371/journal.pone.0085472 10.1007/s12272-011-0609-y 10.1615/CritRevTherDrugCarrierSyst.2014010920 10.1093/jac/dkt374 10.3389/fpubh.2014.00217 10.1517/17425247.2012.717926 10.1007/s00104-012-2393-8 10.1007/s10856-013-5122-z 10.1208/s12248-010-9213-1 |
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Snippet | In this study, vancomycin loaded alginate–chitosan composite microspheres were developed by emulsion cross‐linking method. The in vitro and vivo... In this study, vancomycin loaded alginate-chitosan composite microspheres were developed by emulsion cross-linking method. The in vitro and vivo... In this study, vancomycin loaded alginate–chitosan composite microspheres were developed by emulsion cross‐linking method. The in vitro and vivo... |
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SubjectTerms | alginate-chitosan composite microspheres Alginates - chemistry Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Chitosan - chemistry Chromatography, High Pressure Liquid Drug Implants Female Glucuronic Acid - chemistry Hexuronic Acids - chemistry in vitro release Male Microscopy, Electron, Scanning Microspheres pharmacokinetics Rabbits vancomycin Vancomycin - administration & dosage Vancomycin - pharmacokinetics |
Title | Novel Alginate-Chitosan Composite Microspheres for Implant Delivery of Vancomycin and In Vivo Evaluation |
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