Immunologic response to inhaled endotoxin: changes in peripheral cell surface markers in normal individuals

• Published in: Journal of occupational and environmental medicine Vol. 46; no. 5; p. 467
• Main Authors: Fishwick, David, Barber, Chris, Beckett, Paul, Bradshaw, Lisa M, Rawbone, Roger, Curran, Andrew David
• Format: Journal Article
• Language: English
• Published: United States 01.05.2004
• Subjects: Adult; Flow Cytometry; Humans; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Lipopolysaccharide Receptors - analysis; Lipopolysaccharide Receptors - metabolism; Middle Aged; Up-Regulation

Monocyte cell surface CD14 increases following both in vitro challenge with lipopolysaccharide (LPS) and exposure to organic dusts. We investigated 9 volunteers, mean age 39 years (range, 29-53 years). Each inhaled increasing concentrations of lipopolysaccharide (0.5 microg, 5.0 microg, and 20 micro...