High glucose promotes atherosclerosis by regulating miRNA let7d‐5p level
ABSTRACT Background MiRNA let7d‐5p has been recently reported to be abnormally expressed in diabetes‐associated atherosclerosis (AS). However, it still remains unknown how let7d‐5p contributes to the process of atherosclerosis. Methods Twenty fresh tissues and a total of 28 wax block specimens from...
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| Published in | Journal of diabetes investigation Vol. 15; no. 6; pp. 711 - 724 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
John Wiley & Sons, Inc
01.06.2024
John Wiley and Sons Inc Wiley |
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| Abstract | ABSTRACT
Background
MiRNA let7d‐5p has been recently reported to be abnormally expressed in diabetes‐associated atherosclerosis (AS). However, it still remains unknown how let7d‐5p contributes to the process of atherosclerosis.
Methods
Twenty fresh tissues and a total of 28 wax block specimens from carotid endarterectomy procedures were obtained from the Luoyang Central Hospital affiliated to Zhengzhou University. The expression of let7d‐5p was assessed using quantitative RT‐PCR (qRT‐PCR). A series of in vitro experiments was used to determine the roles of let7d‐5p knockdown and overexpression in vascular smooth muscle cells (VSMCs).
Results
We discovered that the carotid plaques from diabetic patients had lower expression levels of miR let7d‐5p. In VSMCs, the expression of miRNA let7d‐5p was significantly lower in high glucose conditions compared with low glucose situations. The proliferation and migration of VSMCs were also inhibited by the overexpression of let7d‐5p, whereas the opposite was true when let7d‐5p was inhibited, according to gain and loss of function studies. Mechanically, let7d‐5p might activate the GSK3β/β‐catenin signaling pathway via binding to the high mobility group AT‐Hook 2 (HMGA2) mRNA in VSMCs. Additionally, GLP‐1RA liraglutide may prevent the migration and proliferation of VSMCs by raising let7d‐5p levels.
Conclusions
High glucose stimulated the proliferation and migration of VSMCs by regulating the let7d‐5p/HMGA2/GSK3β/β‐catenin pathway, and liraglutide may slow atherosclerosis by increasing the levels of miR let7d‐5p.
In this study, we reported that the miR let7d‐5p expression was decreased in the carotid plaque of patients with diabetes. We first revealed high glucose promoted the proliferation and migration of VSMCs by regulating the let7d‐5p/HMGA2/GSK3β/β‐catenin pathway, and liraglutide may alleviate atherosclerosis via up‐regulating miR let7d‐5p levels. GLP‐1RA liraglutide could inhibit the proliferation and migration of VSMCs by up‐regulating the level of let7d‐5p. |
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| AbstractList | MiRNA let7d-5p has been recently reported to be abnormally expressed in diabetes-associated atherosclerosis (AS). However, it still remains unknown how let7d-5p contributes to the process of atherosclerosis.
Twenty fresh tissues and a total of 28 wax block specimens from carotid endarterectomy procedures were obtained from the Luoyang Central Hospital affiliated to Zhengzhou University. The expression of let7d-5p was assessed using quantitative RT-PCR (qRT-PCR). A series of in vitro experiments was used to determine the roles of let7d-5p knockdown and overexpression in vascular smooth muscle cells (VSMCs).
We discovered that the carotid plaques from diabetic patients had lower expression levels of miR let7d-5p. In VSMCs, the expression of miRNA let7d-5p was significantly lower in high glucose conditions compared with low glucose situations. The proliferation and migration of VSMCs were also inhibited by the overexpression of let7d-5p, whereas the opposite was true when let7d-5p was inhibited, according to gain and loss of function studies. Mechanically, let7d-5p might activate the GSK3β/β-catenin signaling pathway via binding to the high mobility group AT-Hook 2 (HMGA2) mRNA in VSMCs. Additionally, GLP-1RA liraglutide may prevent the migration and proliferation of VSMCs by raising let7d-5p levels.
High glucose stimulated the proliferation and migration of VSMCs by regulating the let7d-5p/HMGA2/GSK3β/β-catenin pathway, and liraglutide may slow atherosclerosis by increasing the levels of miR let7d-5p. MiRNA let7d-5p has been recently reported to be abnormally expressed in diabetes-associated atherosclerosis (AS). However, it still remains unknown how let7d-5p contributes to the process of atherosclerosis.BACKGROUNDMiRNA let7d-5p has been recently reported to be abnormally expressed in diabetes-associated atherosclerosis (AS). However, it still remains unknown how let7d-5p contributes to the process of atherosclerosis.Twenty fresh tissues and a total of 28 wax block specimens from carotid endarterectomy procedures were obtained from the Luoyang Central Hospital affiliated to Zhengzhou University. The expression of let7d-5p was assessed using quantitative RT-PCR (qRT-PCR). A series of in vitro experiments was used to determine the roles of let7d-5p knockdown and overexpression in vascular smooth muscle cells (VSMCs).METHODSTwenty fresh tissues and a total of 28 wax block specimens from carotid endarterectomy procedures were obtained from the Luoyang Central Hospital affiliated to Zhengzhou University. The expression of let7d-5p was assessed using quantitative RT-PCR (qRT-PCR). A series of in vitro experiments was used to determine the roles of let7d-5p knockdown and overexpression in vascular smooth muscle cells (VSMCs).We discovered that the carotid plaques from diabetic patients had lower expression levels of miR let7d-5p. In VSMCs, the expression of miRNA let7d-5p was significantly lower in high glucose conditions compared with low glucose situations. The proliferation and migration of VSMCs were also inhibited by the overexpression of let7d-5p, whereas the opposite was true when let7d-5p was inhibited, according to gain and loss of function studies. Mechanically, let7d-5p might activate the GSK3β/β-catenin signaling pathway via binding to the high mobility group AT-Hook 2 (HMGA2) mRNA in VSMCs. Additionally, GLP-1RA liraglutide may prevent the migration and proliferation of VSMCs by raising let7d-5p levels.RESULTSWe discovered that the carotid plaques from diabetic patients had lower expression levels of miR let7d-5p. In VSMCs, the expression of miRNA let7d-5p was significantly lower in high glucose conditions compared with low glucose situations. The proliferation and migration of VSMCs were also inhibited by the overexpression of let7d-5p, whereas the opposite was true when let7d-5p was inhibited, according to gain and loss of function studies. Mechanically, let7d-5p might activate the GSK3β/β-catenin signaling pathway via binding to the high mobility group AT-Hook 2 (HMGA2) mRNA in VSMCs. Additionally, GLP-1RA liraglutide may prevent the migration and proliferation of VSMCs by raising let7d-5p levels.High glucose stimulated the proliferation and migration of VSMCs by regulating the let7d-5p/HMGA2/GSK3β/β-catenin pathway, and liraglutide may slow atherosclerosis by increasing the levels of miR let7d-5p.CONCLUSIONSHigh glucose stimulated the proliferation and migration of VSMCs by regulating the let7d-5p/HMGA2/GSK3β/β-catenin pathway, and liraglutide may slow atherosclerosis by increasing the levels of miR let7d-5p. BackgroundMiRNA let7d-5p has been recently reported to be abnormally expressed in diabetes-associated atherosclerosis (AS). However, it still remains unknown how let7d-5p contributes to the process of atherosclerosis.MethodsTwenty fresh tissues and a total of 28 wax block specimens from carotid endarterectomy procedures were obtained from the Luoyang Central Hospital affiliated to Zhengzhou University. The expression of let7d-5p was assessed using quantitative RT-PCR (qRT-PCR). A series of in vitro experiments was used to determine the roles of let7d-5p knockdown and overexpression in vascular smooth muscle cells (VSMCs).ResultsWe discovered that the carotid plaques from diabetic patients had lower expression levels of miR let7d-5p. In VSMCs, the expression of miRNA let7d-5p was significantly lower in high glucose conditions compared with low glucose situations. The proliferation and migration of VSMCs were also inhibited by the overexpression of let7d-5p, whereas the opposite was true when let7d-5p was inhibited, according to gain and loss of function studies. Mechanically, let7d-5p might activate the GSK3β/β-catenin signaling pathway via binding to the high mobility group AT-Hook 2 (HMGA2) mRNA in VSMCs. Additionally, GLP-1RA liraglutide may prevent the migration and proliferation of VSMCs by raising let7d-5p levels.ConclusionsHigh glucose stimulated the proliferation and migration of VSMCs by regulating the let7d-5p/HMGA2/GSK3β/β-catenin pathway, and liraglutide may slow atherosclerosis by increasing the levels of miR let7d-5p. ABSTRACT Background MiRNA let7d‐5p has been recently reported to be abnormally expressed in diabetes‐associated atherosclerosis (AS). However, it still remains unknown how let7d‐5p contributes to the process of atherosclerosis. Methods Twenty fresh tissues and a total of 28 wax block specimens from carotid endarterectomy procedures were obtained from the Luoyang Central Hospital affiliated to Zhengzhou University. The expression of let7d‐5p was assessed using quantitative RT‐PCR (qRT‐PCR). A series of in vitro experiments was used to determine the roles of let7d‐5p knockdown and overexpression in vascular smooth muscle cells (VSMCs). Results We discovered that the carotid plaques from diabetic patients had lower expression levels of miR let7d‐5p. In VSMCs, the expression of miRNA let7d‐5p was significantly lower in high glucose conditions compared with low glucose situations. The proliferation and migration of VSMCs were also inhibited by the overexpression of let7d‐5p, whereas the opposite was true when let7d‐5p was inhibited, according to gain and loss of function studies. Mechanically, let7d‐5p might activate the GSK3β/β‐catenin signaling pathway via binding to the high mobility group AT‐Hook 2 (HMGA2) mRNA in VSMCs. Additionally, GLP‐1RA liraglutide may prevent the migration and proliferation of VSMCs by raising let7d‐5p levels. Conclusions High glucose stimulated the proliferation and migration of VSMCs by regulating the let7d‐5p/HMGA2/GSK3β/β‐catenin pathway, and liraglutide may slow atherosclerosis by increasing the levels of miR let7d‐5p. ABSTRACT Background MiRNA let7d‐5p has been recently reported to be abnormally expressed in diabetes‐associated atherosclerosis (AS). However, it still remains unknown how let7d‐5p contributes to the process of atherosclerosis. Methods Twenty fresh tissues and a total of 28 wax block specimens from carotid endarterectomy procedures were obtained from the Luoyang Central Hospital affiliated to Zhengzhou University. The expression of let7d‐5p was assessed using quantitative RT‐PCR (qRT‐PCR). A series of in vitro experiments was used to determine the roles of let7d‐5p knockdown and overexpression in vascular smooth muscle cells (VSMCs). Results We discovered that the carotid plaques from diabetic patients had lower expression levels of miR let7d‐5p. In VSMCs, the expression of miRNA let7d‐5p was significantly lower in high glucose conditions compared with low glucose situations. The proliferation and migration of VSMCs were also inhibited by the overexpression of let7d‐5p, whereas the opposite was true when let7d‐5p was inhibited, according to gain and loss of function studies. Mechanically, let7d‐5p might activate the GSK3β/β‐catenin signaling pathway via binding to the high mobility group AT‐Hook 2 (HMGA2) mRNA in VSMCs. Additionally, GLP‐1RA liraglutide may prevent the migration and proliferation of VSMCs by raising let7d‐5p levels. Conclusions High glucose stimulated the proliferation and migration of VSMCs by regulating the let7d‐5p/HMGA2/GSK3β/β‐catenin pathway, and liraglutide may slow atherosclerosis by increasing the levels of miR let7d‐5p. In this study, we reported that the miR let7d‐5p expression was decreased in the carotid plaque of patients with diabetes. We first revealed high glucose promoted the proliferation and migration of VSMCs by regulating the let7d‐5p/HMGA2/GSK3β/β‐catenin pathway, and liraglutide may alleviate atherosclerosis via up‐regulating miR let7d‐5p levels. GLP‐1RA liraglutide could inhibit the proliferation and migration of VSMCs by up‐regulating the level of let7d‐5p. In this study, we reported that the miR let7d‐5p expression was decreased in the carotid plaque of patients with diabetes. We first revealed high glucose promoted the proliferation and migration of VSMCs by regulating the let7d‐5p/HMGA2/GSK3β/β‐catenin pathway, and liraglutide may alleviate atherosclerosis via up‐regulating miR let7d‐5p levels. GLP‐1RA liraglutide could inhibit the proliferation and migration of VSMCs by up‐regulating the level of let7d‐5p. |
| Author | Guo, Yiting Zhang, Yanfang Zhao, Songfeng Li, Xuan Liu, Fentao Wang, Yunlong Mai, Peipei Su, Jie Zhao, Wenyu Wang, Hua Wen, Zhiguo |
| AuthorAffiliation | 4 Department of Vascular Surgery Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang City Henan Province China 3 Department of Endocrinology Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang City Henan Province China 5 Henan Bioengineering Research Center Zhengzhou City Henan Province China 6 Zhongyuan Scholars Workstation of Henan Luoyang City Henan Province China 1 Department of Ultrasonography Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang City Henan Province China 2 ABclonal Technology Company Wuhan Hubei Province China |
| AuthorAffiliation_xml | – name: 4 Department of Vascular Surgery Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang City Henan Province China – name: 6 Zhongyuan Scholars Workstation of Henan Luoyang City Henan Province China – name: 5 Henan Bioengineering Research Center Zhengzhou City Henan Province China – name: 2 ABclonal Technology Company Wuhan Hubei Province China – name: 1 Department of Ultrasonography Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang City Henan Province China – name: 3 Department of Endocrinology Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang City Henan Province China |
| Author_xml | – sequence: 1 givenname: Hua surname: Wang fullname: Wang, Hua organization: Luoyang Central Hospital Affiliated to Zhengzhou University – sequence: 2 givenname: Fentao surname: Liu fullname: Liu, Fentao organization: ABclonal Technology Company – sequence: 3 givenname: Wenyu surname: Zhao fullname: Zhao, Wenyu organization: Luoyang Central Hospital Affiliated to Zhengzhou University – sequence: 4 givenname: Yiting orcidid: 0000-0001-9546-6476 surname: Guo fullname: Guo, Yiting organization: Luoyang Central Hospital Affiliated to Zhengzhou University – sequence: 5 givenname: Peipei surname: Mai fullname: Mai, Peipei organization: Luoyang Central Hospital Affiliated to Zhengzhou University – sequence: 6 givenname: Songfeng surname: Zhao fullname: Zhao, Songfeng organization: Luoyang Central Hospital Affiliated to Zhengzhou University – sequence: 7 givenname: Zhiguo surname: Wen fullname: Wen, Zhiguo organization: Luoyang Central Hospital Affiliated to Zhengzhou University – sequence: 8 givenname: Jie surname: Su fullname: Su, Jie organization: Luoyang Central Hospital Affiliated to Zhengzhou University – sequence: 9 givenname: Xuan surname: Li fullname: Li, Xuan organization: Luoyang Central Hospital Affiliated to Zhengzhou University – sequence: 10 givenname: Yunlong surname: Wang fullname: Wang, Yunlong organization: Zhongyuan Scholars Workstation of Henan – sequence: 11 givenname: Yanfang orcidid: 0000-0002-1999-3079 surname: Zhang fullname: Zhang, Yanfang email: yanfangz@zzu.edu.cn organization: Zhongyuan Scholars Workstation of Henan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38483136$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1139/cjpp-2020-0399 10.1016/j.tig.2007.02.011 10.1038/s41418-018-0243-z 10.1098/rsob.200128 10.1016/j.bbalip.2021.159005 10.1155/2018/4769596 10.1056/NEJMoa1603827 10.1016/j.peptides.2021.170732 10.1016/j.bbrc.2016.09.154 10.5551/jat.RV17014 10.1016/j.diabres.2018.02.023 10.1016/j.vph.2018.11.006 10.2337/db16-1405 10.1074/jbc.RA120.015486 10.1074/jbc.RA118.005398 10.1177/17085381221098826 10.2174/1381612811319320005 10.1101/gr.082701.108 10.1161/ATVBAHA.115.306770 10.1038/35040556 10.1177/1479164113481817 10.1089/dna.2017.3957 10.1093/cvr/cvz203 10.1371/journal.pone.0188980 10.1038/nrendo.2017.151 10.1186/s40169-019-0240-y 10.1152/ajpendo.00236.2013 10.1016/j.bbrc.2018.08.155 10.1016/j.gene.2018.09.010 10.1016/S0140-6736(11)60679-X 10.1161/CIRCRESAHA.120.316489 10.1038/35002607 10.1172/JCI124508 10.1038/sj.bjc.6601391 10.1039/C9RA01031A 10.1016/j.cmet.2016.06.009 10.2522/ptj.20080008 10.1016/j.tcb.2008.07.007 10.3892/etm.2021.9923 10.1111/apha.12466 10.2337/db17-1434 10.1002/cbin.10543 10.21037/atm.2019.12.145 10.1016/j.omtn.2020.08.013 10.1007/s00432-021-03745-w 10.1093/cvr/cvx249 10.1093/nar/19.24.6793 10.1186/1475-2840-13-49 10.1016/j.biopha.2018.01.014 10.1164/rccm.201903-0508OC 10.5761/atcs.oa.19-00184 10.1101/gad.1074403 10.1016/j.jegh.2015.05.003 10.1093/nar/gkm641 10.1161/CIRCULATIONAHA.117.027799 10.3389/fimmu.2020.599415 10.1517/14712598.2015.1067299 |
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| Copyright | 2024 The Authors. published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. 2024 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. 2024. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| References | 2023; 31 1991; 19 2021; 21 2019; 54 2020; 126 2003; 17 2020; 11 2019; 129 2020; 10 2016; 36 2007; 35 2017; 9 2019; 200 2013; 19 2020; 8 2000; 408 2020; 295 2018; 138 2015; 214 2013; 10 2000; 403 2018; 137 2019; 26 2019; 115 2021; 150 2016; 40 2014; 13 2016; 479 2009; 19 2007; 23 2018; 37 2019; 112 2003; 89 2019; 8 2011; 378 2015; 15 2019; 9 2015; 5 2018; 504 2021; 147 2017; 66 2008; 18 2013; 305 2018; 67 2012; 32 2018; 25 2018; 2018 2021; 99 2021; 1866 2018; 679 2018; 114 2017; 12 2020; 26 2016; 375 2008; 88 2020; 22 2019; 294 2018; 99 2016; 24 2018; 14 e_1_2_7_5_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_60_1 e_1_2_7_17_1 e_1_2_7_62_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_11_1 e_1_2_7_45_1 Chen YN (e_1_2_7_51_1) 2019; 54 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_49_1 e_1_2_7_28_1 e_1_2_7_50_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_54_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_56_1 e_1_2_7_37_1 e_1_2_7_39_1 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_8_1 Shi X (e_1_2_7_52_1) 2017; 9 e_1_2_7_18_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_61_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_48_1 e_1_2_7_27_1 e_1_2_7_29_1 e_1_2_7_30_1 e_1_2_7_53_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_55_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_57_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_59_1 e_1_2_7_38_1 Ye H (e_1_2_7_58_1) 2012; 32 |
| References_xml | – volume: 129 start-page: 1372 year: 2019 end-page: 1386 article-title: Platelet‐derived miR‐223 promotes a phenotypic switch in arterial injury repair publication-title: J Clin Invest – volume: 35 start-page: 5944 year: 2007 end-page: 5953 article-title: Tissue‐dependent paired expression of miRNAs publication-title: Nucleic Acids Res – volume: 22 start-page: 84 year: 2020 end-page: 98 article-title: Long non‐coding RNA PEBP1P2 suppresses proliferative VSMCs phenotypic switching and proliferation in atherosclerosis publication-title: Mol Ther Nucleic Acids – volume: 479 start-page: 676 year: 2016 end-page: 682 article-title: Let‐7d miRNA prevents TGF‐β1‐induced EMT and renal fibrogenesis through regulation of HMGA2 expression publication-title: Biochem Biophys Res Commun – volume: 9 start-page: 19355 year: 2019 end-page: 19364 article-title: miR‐let‐7d attenuates EMT by targeting HMGA2 in silica‐induced pulmonary fibrosis publication-title: RSC Adv – volume: 23 start-page: 243 year: 2007 end-page: 249 article-title: Mechanisms of microRNA‐mediated gene regulation in animal cells publication-title: Trends Genet – volume: 37 start-page: 389 year: 2018 end-page: 397 article-title: HMGA1 mediated high‐glucose‐induced vascular smooth muscle cell proliferation in diabetes mellitus: Association between PI3K/Akt signaling and HMGA1 expression publication-title: DNA Cell Biol – volume: 10 year: 2020 article-title: The role of Wnt signalling in development of coronary artery disease and its risk factors publication-title: Open Biol – volume: 18 start-page: 505 year: 2008 end-page: 516 article-title: The let‐7 family of microRNAs publication-title: Trends Cell Biol – volume: 147 start-page: 3313 year: 2021 end-page: 3324 article-title: Prognostic significance of high mobility group A2 (HMGA2) in pancreatic ductal adenocarcinoma: Malignant functions of cytoplasmic HMGA2 expression publication-title: J Cancer Res Clin Oncol – volume: 2018 year: 2018 article-title: SIRT7 regulates the vascular smooth muscle cells proliferation and migration via Wnt/beta‐catenin signaling pathway publication-title: Biomed Res Int – volume: 15 start-page: 1391 year: 2015 end-page: 1397 article-title: Liraglutide improves carotid intima‐media thickness in patients with type 2 diabetes and non‐alcoholic fatty liver disease: An 8‐month prospective pilot study publication-title: Expert Opin Biol Ther – volume: 17 start-page: 991 year: 2003 end-page: 1008 article-title: The microRNAs of Caenorhabditis elegans publication-title: Genes Dev – volume: 54 start-page: 1771 year: 2019 end-page: 1784 article-title: MicroRNA let7d5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1 publication-title: Int J Oncol – volume: 138 start-page: 271 year: 2018 end-page: 281 article-title: IDF diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045 publication-title: Diabetes Res Clin Pract – volume: 19 start-page: 6793 year: 1991 end-page: 6797 article-title: cDNA cloning of the HMGI‐C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes publication-title: Nucleic Acids Res – volume: 1866 year: 2021 article-title: Induction of microRNA hsa‐let‐7d‐5p, and repression of HMGA2, contribute protection against lipid accumulation in macrophage ‘foam’ cells publication-title: Biochim Biophys Acta Mol Cell Biol Lipids – volume: 12 year: 2017 article-title: A unique plasma microRNA profile defines type 2 diabetes progression publication-title: PloS One – volume: 5 start-page: S35 issue: 4 Suppl 1 year: 2015 end-page: S43 article-title: Prevalence of self‐reported sleep duration and sleep habits in type 2 diabetes patients in South Trinidad publication-title: J Epidemiol Glob Health – volume: 24 start-page: 15 year: 2016 end-page: 30 article-title: The cardiovascular biology of glucagon‐like Peptide‐1 publication-title: Cell Metab – volume: 214 start-page: 33 year: 2015 end-page: 50 article-title: Vascular smooth muscle cell in atherosclerosis publication-title: Acta Physiol (Oxf) – volume: 8 start-page: 24 year: 2019 article-title: Let‐7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer publication-title: Clin Transl Med – volume: 40 start-page: 121 year: 2016 end-page: 130 article-title: Hyperlipidemia induces vascular smooth muscle cell proliferation involving Wnt/beta‐catenin signaling publication-title: Cell Biol Int – volume: 114 start-page: 611 year: 2018 end-page: 621 article-title: Non‐coding RNAs: Key regulators of smooth muscle cell fate in vascular disease publication-title: Cardiovasc Res – volume: 126 start-page: e120 year: 2020 end-page: e135 article-title: miR‐128‐3p is a novel regulator of vascular smooth muscle cell phenotypic switch and vascular diseases publication-title: Circ Res – volume: 31 start-page: 1240 year: 2023 end-page: 1252 article-title: Effect of miR‐663 on atherosclerosis by regulating the proliferation of vascular smooth muscle cells in lipid plaques publication-title: Vascular – volume: 378 start-page: 31 year: 2011 end-page: 40 article-title: National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country‐years and 2·7 million participants publication-title: Lancet – volume: 679 start-page: 266 year: 2018 end-page: 273 article-title: The miR‐143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm publication-title: Gene – volume: 305 start-page: E1359 year: 2013 end-page: E1366 article-title: Autocrine role of interleukin‐13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let‐7 publication-title: Am J Physiol Endocrinol Metab – volume: 25 start-page: 27 year: 2018 end-page: 39 article-title: Mechanism of development of atherosclerosis and cardiovascular disease in diabetes mellitus publication-title: J Atheroscler Thromb – volume: 99 start-page: 81 year: 2018 end-page: 86 article-title: MicroRNA‐145 alleviates high glucose‐induced proliferation and migration of vascular smooth muscle cells through targeting ROCK1 publication-title: Biomed Pharmacother – volume: 295 start-page: 16314 year: 2020 end-page: 16327 article-title: TL1A inhibits atherosclerosis in apoE‐deficient mice by regulating the phenotype of vascular smooth muscle cells publication-title: J Biol Chem – volume: 504 start-page: 196 year: 2018 end-page: 202 article-title: High mobility group A2 (HMGA2) promotes EMT via MAPK pathway in prostate cancer publication-title: Biochem Biophys Res Commun – volume: 294 start-page: 2407 year: 2019 end-page: 2421 article-title: Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate‐1‐mediated p53/KLF4 complex stabilization publication-title: J Biol Chem – volume: 26 start-page: 1782 year: 2019 end-page: 1795 article-title: miR‐92b‐3p‐TSC1 axis is critical for mTOR signaling‐mediated vascular smooth muscle cell proliferation induced by hypoxia publication-title: Cell Death Differ – volume: 99 start-page: 171 year: 2021 end-page: 178 article-title: Vascular smooth muscle remodeling in health and disease publication-title: Can J Physiol Pharmacol – volume: 112 start-page: 24 year: 2019 end-page: 30 article-title: The function of miR‐143, miR‐145 and the MiR‐143 host gene in cardiovascular development and disease publication-title: Vascul Pharmacol – volume: 66 start-page: 2266 year: 2017 end-page: 2277 article-title: Protective effect of let‐7 miRNA family in regulating inflammation in diabetes–Associated atherosclerosis publication-title: Diabetes – volume: 375 start-page: 311 year: 2016 end-page: 322 article-title: Liraglutide and cardiovascular outcomes in type 2 diabetes publication-title: N Engl J Med – volume: 32 start-page: 1752 year: 2012 end-page: 1757 article-title: Construction of let‐7d expression vector and its inhibitory effect on HMGA2 and ras expression in human ovarian cancer cells in vitro publication-title: Nan Fang Yi Ke Da Xue Xue Bao – volume: 21 start-page: 492 year: 2021 article-title: MicroRNA‐29b inhibits human vascular smooth muscle cell proliferation via targeting the TGF‐beta/Smad3 signaling pathway publication-title: Exp Ther Med – volume: 8 start-page: 157 year: 2020 article-title: Targeting the mitogen‐activated protein kinase‐mediated vascular smooth muscle cell remodeling by angiotensin II publication-title: Ann Transl Med – volume: 9 start-page: 167 year: 2017 end-page: 174 article-title: GSK3β activity is essential for senescence‐associated heterochromatin foci (SAHF) formation induced by HMGA2 in WI38 cells publication-title: Am J Transl Res – volume: 200 start-page: 1246 year: 2019 end-page: 1257 article-title: MicroRNA let‐7 downregulates ligand‐independent estrogen receptor‐mediated male‐predominant pulmonary fibrosis publication-title: Am J Respir Crit Care Med – volume: 14 start-page: 88 year: 2018 end-page: 98 article-title: Global aetiology and epidemiology of type 2 diabetes mellitus and its complications publication-title: Nat Rev Endocrinol – volume: 67 start-page: 2554 year: 2018 end-page: 2568 article-title: miRNA regulation of the hyperproliferative phenotype of vascular smooth muscle cells in diabetes publication-title: Diabetes – volume: 150 year: 2021 article-title: Inhibitors of the MAPK/ NF‐kappaB pathway attenuate the upregulation of the ETB receptor mediated by high glucose in vascular smooth muscle cells publication-title: Peptides – volume: 10 start-page: 353 year: 2013 end-page: 360 article-title: The GLP‐1 receptor agonist liraglutide inhibits progression of vascular disease via effects on atherogenesis, plaque stability and endothelial function in an ApoE−/− mouse model publication-title: Diab Vasc Dis Res – volume: 36 start-page: 864 year: 2016 end-page: 873 article-title: Regulation of vascular smooth muscle cell dysfunction under diabetic conditions by miR‐504 publication-title: Arterioscler Thromb Vasc Biol – volume: 403 start-page: 901 year: 2000 end-page: 906 article-title: The 21‐nucleotide let‐7 RNA regulates developmental timing in publication-title: Nature – volume: 137 start-page: 1824 year: 2018 end-page: 1841 article-title: miR‐22 is a novel mediator of vascular smooth muscle cell phenotypic modulation and neointima formation publication-title: Circulation – volume: 408 start-page: 86 year: 2000 end-page: 89 article-title: Conservation of the sequence and temporal expression of let‐7 heterochronic regulatory RNA publication-title: Nature – volume: 11 year: 2020 article-title: Role of vascular smooth muscle cell plasticity and interactions in Vessel Wall inflammation publication-title: Front Immunol – volume: 115 start-page: 1732 year: 2019 end-page: 1756 article-title: Non‐coding RNAs in cardiovascular cell biology and atherosclerosis publication-title: Cardiovasc Res – volume: 26 start-page: 140 year: 2020 end-page: 150 article-title: MiR‐26b suppresses the development of Stanford type a aortic dissection by regulating HMGA2 and TGF‐β/Smad3 signaling pathway publication-title: Ann Thorac Cardiovasc Surg – volume: 19 start-page: 5695 year: 2013 end-page: 5703 article-title: Hyperglycemia‐induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases publication-title: Curr Pharm Des – volume: 88 start-page: 1322 year: 2008 end-page: 1335 article-title: Diabetes‐related microvascular and macrovascular diseases in the physical therapy setting publication-title: Phys Ther – volume: 89 start-page: 2104 year: 2003 end-page: 2109 article-title: An increased high‐mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue publication-title: Br J Cancer – volume: 13 start-page: 49 year: 2014 article-title: Liraglutide decreases carotid intima‐media thickness in patients with type 2 diabetes: 8‐month prospective pilot study publication-title: Cardiovasc Diabetol – volume: 19 start-page: 92 year: 2009 end-page: 105 article-title: Most mammalian mRNAs are conserved targets of microRNAs publication-title: Genome Res – volume: 66 start-page: 2266 year: 2017 end-page: 2277 article-title: Protective effect of let‐7 miRNA family in regulating inflammation in diabetes‐associated atherosclerosis publication-title: Diabetes – ident: e_1_2_7_7_1 doi: 10.1139/cjpp-2020-0399 – volume: 54 start-page: 1771 year: 2019 ident: e_1_2_7_51_1 article-title: MicroRNA let7d5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1 publication-title: Int J Oncol contributor: fullname: Chen YN – ident: e_1_2_7_24_1 doi: 10.1016/j.tig.2007.02.011 – ident: e_1_2_7_20_1 doi: 10.1038/s41418-018-0243-z – ident: e_1_2_7_33_1 doi: 10.1098/rsob.200128 – ident: e_1_2_7_57_1 doi: 10.1016/j.bbalip.2021.159005 – ident: e_1_2_7_10_1 doi: 10.1155/2018/4769596 – ident: e_1_2_7_59_1 doi: 10.1056/NEJMoa1603827 – ident: e_1_2_7_34_1 doi: 10.1016/j.peptides.2021.170732 – ident: e_1_2_7_38_1 doi: 10.1016/j.bbrc.2016.09.154 – ident: e_1_2_7_42_1 doi: 10.5551/jat.RV17014 – ident: e_1_2_7_4_1 doi: 10.1016/j.diabres.2018.02.023 – ident: e_1_2_7_46_1 doi: 10.1016/j.vph.2018.11.006 – ident: e_1_2_7_22_1 doi: 10.2337/db16-1405 – ident: e_1_2_7_13_1 doi: 10.1074/jbc.RA120.015486 – ident: e_1_2_7_12_1 doi: 10.1074/jbc.RA118.005398 – ident: e_1_2_7_55_1 doi: 10.1177/17085381221098826 – ident: e_1_2_7_6_1 doi: 10.2174/1381612811319320005 – ident: e_1_2_7_35_1 doi: 10.1101/gr.082701.108 – ident: e_1_2_7_14_1 doi: 10.1161/ATVBAHA.115.306770 – ident: e_1_2_7_27_1 doi: 10.1038/35040556 – ident: e_1_2_7_60_1 doi: 10.1177/1479164113481817 – ident: e_1_2_7_32_1 doi: 10.1089/dna.2017.3957 – ident: e_1_2_7_15_1 doi: 10.1093/cvr/cvz203 – ident: e_1_2_7_50_1 doi: 10.1371/journal.pone.0188980 – ident: e_1_2_7_41_1 doi: 10.1038/nrendo.2017.151 – ident: e_1_2_7_30_1 doi: 10.1186/s40169-019-0240-y – ident: e_1_2_7_49_1 doi: 10.1152/ajpendo.00236.2013 – ident: e_1_2_7_48_1 doi: 10.2337/db16-1405 – ident: e_1_2_7_54_1 doi: 10.1016/j.bbrc.2018.08.155 – ident: e_1_2_7_47_1 doi: 10.1016/j.gene.2018.09.010 – ident: e_1_2_7_2_1 doi: 10.1016/S0140-6736(11)60679-X – ident: e_1_2_7_19_1 doi: 10.1161/CIRCRESAHA.120.316489 – ident: e_1_2_7_26_1 doi: 10.1038/35002607 – volume: 9 start-page: 167 year: 2017 ident: e_1_2_7_52_1 article-title: GSK3β activity is essential for senescence‐associated heterochromatin foci (SAHF) formation induced by HMGA2 in WI38 cells publication-title: Am J Transl Res contributor: fullname: Shi X – ident: e_1_2_7_18_1 doi: 10.1172/JCI124508 – volume: 32 start-page: 1752 year: 2012 ident: e_1_2_7_58_1 article-title: Construction of let‐7d expression vector and its inhibitory effect on HMGA2 and ras expression in human ovarian cancer cells in vitro publication-title: Nan Fang Yi Ke Da Xue Xue Bao contributor: fullname: Ye H – ident: e_1_2_7_36_1 doi: 10.1038/sj.bjc.6601391 – ident: e_1_2_7_39_1 doi: 10.1039/C9RA01031A – ident: e_1_2_7_40_1 doi: 10.1016/j.cmet.2016.06.009 – ident: e_1_2_7_5_1 doi: 10.2522/ptj.20080008 – ident: e_1_2_7_28_1 doi: 10.1016/j.tcb.2008.07.007 – ident: e_1_2_7_8_1 doi: 10.3892/etm.2021.9923 – ident: e_1_2_7_44_1 doi: 10.1111/apha.12466 – ident: e_1_2_7_21_1 doi: 10.2337/db17-1434 – ident: e_1_2_7_45_1 doi: 10.1002/cbin.10543 – ident: e_1_2_7_9_1 doi: 10.21037/atm.2019.12.145 – ident: e_1_2_7_11_1 doi: 10.1016/j.omtn.2020.08.013 – ident: e_1_2_7_53_1 doi: 10.1007/s00432-021-03745-w – ident: e_1_2_7_16_1 doi: 10.1093/cvr/cvx249 – ident: e_1_2_7_37_1 doi: 10.1093/nar/19.24.6793 – ident: e_1_2_7_61_1 doi: 10.1186/1475-2840-13-49 – ident: e_1_2_7_23_1 doi: 10.1016/j.biopha.2018.01.014 – ident: e_1_2_7_31_1 doi: 10.1164/rccm.201903-0508OC – ident: e_1_2_7_56_1 doi: 10.5761/atcs.oa.19-00184 – ident: e_1_2_7_25_1 doi: 10.1101/gad.1074403 – ident: e_1_2_7_3_1 doi: 10.1016/j.jegh.2015.05.003 – ident: e_1_2_7_29_1 doi: 10.1093/nar/gkm641 – ident: e_1_2_7_17_1 doi: 10.1161/CIRCULATIONAHA.117.027799 – ident: e_1_2_7_43_1 doi: 10.3389/fimmu.2020.599415 – ident: e_1_2_7_62_1 doi: 10.1517/14712598.2015.1067299 |
| SSID | ssj0000388667 |
| Score | 2.3684888 |
| Snippet | ABSTRACT
Background
MiRNA let7d‐5p has been recently reported to be abnormally expressed in diabetes‐associated atherosclerosis (AS). However, it still remains... MiRNA let7d-5p has been recently reported to be abnormally expressed in diabetes-associated atherosclerosis (AS). However, it still remains unknown how... ABSTRACT Background MiRNA let7d‐5p has been recently reported to be abnormally expressed in diabetes‐associated atherosclerosis (AS). However, it still remains... BackgroundMiRNA let7d-5p has been recently reported to be abnormally expressed in diabetes-associated atherosclerosis (AS). However, it still remains unknown... In this study, we reported that the miR let7d‐5p expression was decreased in the carotid plaque of patients with diabetes. We first revealed high glucose... |
| SourceID | doaj pubmedcentral proquest crossref pubmed wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 711 |
| SubjectTerms | Arteriosclerosis Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism beta Catenin - genetics beta Catenin - metabolism Blood vessels Cell Movement Cell Proliferation Cells, Cultured Diabetes Diabetes mellitus Female Genotype & phenotype Glucose Glucose - metabolism Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism High mobility group proteins HMGA2 Protein - genetics HMGA2 Protein - metabolism Humans Hyperglycemia Male MicroRNAs MicroRNAs - genetics Middle Aged miRNA MiRNA let7d‐5p mRNA Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Original Signal Transduction Smooth muscle Type 2 diabetes mellitus β-Catenin |
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| Title | High glucose promotes atherosclerosis by regulating miRNA let7d‐5p level |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjdi.14180 https://www.ncbi.nlm.nih.gov/pubmed/38483136 https://www.proquest.com/docview/3062829926 https://www.proquest.com/docview/2957167942 https://pubmed.ncbi.nlm.nih.gov/PMC11143425 https://doaj.org/article/f4951f040e7d43aa836b4c753ec97fa8 |
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