Cdc42 improve SARS-CoV-2 spike protein-induced cellular senescence through activating of Wnt/β-Catenin signaling pathway

• Published in: Frontiers in cellular and infection microbiology Vol. 14; p. 1449423
• Main Authors: Nong, Chunmei, Wu, Zhenzhen, Yang, Chan, Xu, Wei, Luo, Linyi, Zhou, Jianping, Shen, Lihan, Chen, Yinghua, Yuan, Yaoqin, Hu, Guodong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.11.2024
• Subjects: Animals; beta Catenin - metabolism; Cdc42; cdc42 GTP-Binding Protein - metabolism; Cellular and Infection Microbiology; Cellular Senescence; COVID-19 - metabolism; COVID-19 - virology; Disease Models, Animal; Humans; Lung - metabolism; Lung - pathology; Lung - virology; Mice; SARS-CoV-2; senescence; spike; Spike Glycoprotein, Coronavirus - metabolism; Wnt Signaling Pathway; β-catenin; senescence; β-catenin; SARS-CoV-2; Cdc42; spike

SARS-CoV-2 infection drove senescent cells and the senescence-associated phenotypes were reported playing roles in disease progression, which contributes to severe COVID-19 and related sequelae. Cdc42 is involved in the regulation of cellular senescence. This study, aimed to investigate the mechanis...