Genital Inflammation and the Risk of HIV Acquisition in Women

• Published in: Clinical infectious diseases Vol. 61; no. 2; pp. 260 - 269
• Main Authors: Masson, Lindi, Passmore, Jo-Ann S., Liebenberg, Lenine J., Werner, Lise, Baxter, Cheryl, Arnold, Kelly B., Wiliamson, Carolyn, Little, Francesca, Mansoor, Leila E., Naranbhai, Vivek, Lauffenburger, Douglas A., Ronacher, Katharina, Walzi, Gerhard, Garrett, Nigel J., Williams, Brent L., Couto-Rodriguez, Mara, Hornig, Mady, Lipkin, W. Ian, Grobler, Anneke, Karim, Quarraisha Abdool, Karim, Salim S. Abdool
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 15.07.2015
• Subjects: Africa; Cervix Uteri - immunology; Chemokine CCL2 - analysis; Chemokine CCL2 - blood; Chemokine CCL2 - immunology; Chemokines - analysis; Chemokines - blood; Chemokines - genetics; Chemokines - immunology; Cytokines; Cytokines - analysis; Cytokines - blood; Cytokines - genetics; Cytokines - immunology; Disease Susceptibility; Female; Genital Diseases, Female - diagnosis; Genitalia, Female - immunology; Genitalia, Female - virology; HIV; HIV Infections - immunology; HIV Infections - transmission; HIV Infections - virology; HIV/AIDS; Human immunodeficiency virus; Humans; Inflammation - diagnosis; Inflammatory diseases; Interferon; Interferon-gamma - analysis; Interferon-gamma - blood; Interferon-gamma - immunology; Interleukin-10 - analysis; Interleukin-10 - immunology; Interleukin-6 - analysis; Interleukin-6 - blood; Interleukin-6 - immunology; Interleukin-8 - analysis; Interleukin-8 - blood; Interleukin-8 - immunology; Sexually Transmitted Diseases; South Africa; Tumor Necrosis Factor-alpha - analysis; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - immunology; Urogenital system; Uterine Cervicitis - diagnosis; Vagina - immunology; Vaginal Douching; Vaginitis - diagnosis; Women; Young Adult; South Africa; Africa; cytokine; female genital tract; inflammation; HIV transmission

Background. Women in Africa, especially young women, have very high human immunodeficiency virus (HIV) incidence rates that cannot be fully explained by behavioral risks. We investigated whether genital inflammation influenced HIV acquisition in this group. Methods. Twelve selected cytokines, includ...