Association between the lean nonalcoholic fatty liver disease and risk of incident type 2 diabetes in a healthy population of Northwest China: a retrospective cohort study with a 2-year follow-up period
We aimed to explore the metabolic features of lean nonalcoholic fatty liver disease (Lean-NAFLD) and its association with the risk of incident type 2 diabetes in young and middle-aged people. We conducted a retrospective cohort study of 3001 participants who were enrolled in a health check-up progra...
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Published in | Frontiers in endocrinology (Lausanne) Vol. 14; p. 1173757 |
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Abstract | We aimed to explore the metabolic features of lean nonalcoholic fatty liver disease (Lean-NAFLD) and its association with the risk of incident type 2 diabetes in young and middle-aged people.
We conducted a retrospective cohort study of 3001 participants who were enrolled in a health check-up program from January 2018 to December 2020 in the Health Management Center of Karamay People's Hospital. The age, sex, height, weight, body mass index (BMI), blood pressure, waist circumference (WC), fasting plasma glucose (FPG), lipid profiles, serum uric acid and alanine aminotransferase (ALT) of the subjects were collected. The cutoff point of BMI for lean nonalcoholic fatty liver disease is <25 kg/m
. A COX proportional hazard regression model was used to analyze the risk ratio of lean nonalcoholic fatty liver disease to type 2 diabetes mellitus.
Lean NAFLD participants had many metabolic abnormalities, such as overweight and obesity with nonalcoholic fatty liver disease. Compared with lean participants without nonalcoholic fatty liver disease, the fully adjusted hazard ratio (HR) for lean participants with nonalcoholic fatty liver disease was 3.83 (95% CI 2.02-7.24, p<0.01). In the normal waist circumference group (man<90cm, woman<80 cm), compared with lean participants without NAFLD, the adjusted hazard ratios (HRs) of incident type 2 diabetes for lean participants with NAFLD and overweight or obese participants with NAFLD were 1.93 (95% CI 0.70-5.35, p>0.05) and 4.20 (95% CI 1.44-12.22, p<0.05), respectively. For excess waist circumference (man≥90 cm, woman ≥80 cm) compared with lean participants without NAFLD, the adjusted hazard ratios (HRs) of incident type 2 diabetes for lean participants with NAFLD and overweight or obese participants with NAFLD were 3.88 (95% CI 1.56-9.66, p<0.05) and 3.30 (95% CI 1.52-7.14, p<0.05), respectively.
Abdominal obesity is the strongest risk factor for type 2 diabetes in lean nonalcoholic fatty liver disease. |
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AbstractList | AimsWe aimed to explore the metabolic features of lean nonalcoholic fatty liver disease (Lean-NAFLD) and its association with the risk of incident type 2 diabetes in young and middle-aged people. MethodsWe conducted a retrospective cohort study of 3001 participants who were enrolled in a health check-up program from January 2018 to December 2020 in the Health Management Center of Karamay People's Hospital. The age, sex, height, weight, body mass index (BMI), blood pressure, waist circumference (WC), fasting plasma glucose (FPG), lipid profiles, serum uric acid and alanine aminotransferase (ALT) of the subjects were collected. The cutoff point of BMI for lean nonalcoholic fatty liver disease is <25 kg/m2. A COX proportional hazard regression model was used to analyze the risk ratio of lean nonalcoholic fatty liver disease to type 2 diabetes mellitus. ResultsLean NAFLD participants had many metabolic abnormalities, such as overweight and obesity with nonalcoholic fatty liver disease. Compared with lean participants without nonalcoholic fatty liver disease, the fully adjusted hazard ratio (HR) for lean participants with nonalcoholic fatty liver disease was 3.83 (95% CI 2.02-7.24, p<0.01). In the normal waist circumference group (man<90cm, woman<80 cm), compared with lean participants without NAFLD, the adjusted hazard ratios (HRs) of incident type 2 diabetes for lean participants with NAFLD and overweight or obese participants with NAFLD were 1.93 (95% CI 0.70-5.35, p>0.05) and 4.20 (95% CI 1.44-12.22, p<0.05), respectively. For excess waist circumference (man≥90 cm, woman ≥80 cm) compared with lean participants without NAFLD, the adjusted hazard ratios (HRs) of incident type 2 diabetes for lean participants with NAFLD and overweight or obese participants with NAFLD were 3.88 (95% CI 1.56-9.66, p<0.05) and 3.30 (95% CI 1.52-7.14, p<0.05), respectively. ConclusionAbdominal obesity is the strongest risk factor for type 2 diabetes in lean nonalcoholic fatty liver disease. We aimed to explore the metabolic features of lean nonalcoholic fatty liver disease (Lean-NAFLD) and its association with the risk of incident type 2 diabetes in young and middle-aged people. We conducted a retrospective cohort study of 3001 participants who were enrolled in a health check-up program from January 2018 to December 2020 in the Health Management Center of Karamay People's Hospital. The age, sex, height, weight, body mass index (BMI), blood pressure, waist circumference (WC), fasting plasma glucose (FPG), lipid profiles, serum uric acid and alanine aminotransferase (ALT) of the subjects were collected. The cutoff point of BMI for lean nonalcoholic fatty liver disease is <25 kg/m . A COX proportional hazard regression model was used to analyze the risk ratio of lean nonalcoholic fatty liver disease to type 2 diabetes mellitus. Lean NAFLD participants had many metabolic abnormalities, such as overweight and obesity with nonalcoholic fatty liver disease. Compared with lean participants without nonalcoholic fatty liver disease, the fully adjusted hazard ratio (HR) for lean participants with nonalcoholic fatty liver disease was 3.83 (95% CI 2.02-7.24, p<0.01). In the normal waist circumference group (man<90cm, woman<80 cm), compared with lean participants without NAFLD, the adjusted hazard ratios (HRs) of incident type 2 diabetes for lean participants with NAFLD and overweight or obese participants with NAFLD were 1.93 (95% CI 0.70-5.35, p>0.05) and 4.20 (95% CI 1.44-12.22, p<0.05), respectively. For excess waist circumference (man≥90 cm, woman ≥80 cm) compared with lean participants without NAFLD, the adjusted hazard ratios (HRs) of incident type 2 diabetes for lean participants with NAFLD and overweight or obese participants with NAFLD were 3.88 (95% CI 1.56-9.66, p<0.05) and 3.30 (95% CI 1.52-7.14, p<0.05), respectively. Abdominal obesity is the strongest risk factor for type 2 diabetes in lean nonalcoholic fatty liver disease. Aims We aimed to explore the metabolic features of lean nonalcoholic fatty liver disease (Lean-NAFLD) and its association with the risk of incident type 2 diabetes in young and middle-aged people. Methods We conducted a retrospective cohort study of 3001 participants who were enrolled in a health check-up program from January 2018 to December 2020 in the Health Management Center of Karamay People’s Hospital. The age, sex, height, weight, body mass index (BMI), blood pressure, waist circumference (WC), fasting plasma glucose (FPG), lipid profiles, serum uric acid and alanine aminotransferase (ALT) of the subjects were collected. The cutoff point of BMI for lean nonalcoholic fatty liver disease is <25 kg/m 2 . A COX proportional hazard regression model was used to analyze the risk ratio of lean nonalcoholic fatty liver disease to type 2 diabetes mellitus. Results Lean NAFLD participants had many metabolic abnormalities, such as overweight and obesity with nonalcoholic fatty liver disease. Compared with lean participants without nonalcoholic fatty liver disease, the fully adjusted hazard ratio (HR) for lean participants with nonalcoholic fatty liver disease was 3.83 (95% CI 2.02-7.24, p<0.01). In the normal waist circumference group (man<90cm, woman<80 cm), compared with lean participants without NAFLD, the adjusted hazard ratios (HRs) of incident type 2 diabetes for lean participants with NAFLD and overweight or obese participants with NAFLD were 1.93 (95% CI 0.70-5.35, p>0.05) and 4.20 (95% CI 1.44-12.22, p<0.05), respectively. For excess waist circumference (man≥90 cm, woman ≥80 cm) compared with lean participants without NAFLD, the adjusted hazard ratios (HRs) of incident type 2 diabetes for lean participants with NAFLD and overweight or obese participants with NAFLD were 3.88 (95% CI 1.56-9.66, p<0.05) and 3.30 (95% CI 1.52-7.14, p<0.05), respectively. Conclusion Abdominal obesity is the strongest risk factor for type 2 diabetes in lean nonalcoholic fatty liver disease. |
Author | Li, Danting Zhang, Mei Yu Wu, Shengli Tan, Huiwen Xang, Weiting Xie, ChengYao Chang, Min Li, Nong |
AuthorAffiliation | 4 Department of Endocrinology Metabolism, West China Hospital of Sichuan University , Chengdu , China 3 Department of Health Management Center, the Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Karamay , Xinjiang , China 1 Department of Endocrinology and Metabolism, the Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Karamay , Xinjiang , China 2 Department of Health Management Center, West China Hospital, Sichuan University , Chengdu, Sichuan , China |
AuthorAffiliation_xml | – name: 3 Department of Health Management Center, the Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Karamay , Xinjiang , China – name: 2 Department of Health Management Center, West China Hospital, Sichuan University , Chengdu, Sichuan , China – name: 4 Department of Endocrinology Metabolism, West China Hospital of Sichuan University , Chengdu , China – name: 1 Department of Endocrinology and Metabolism, the Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Karamay , Xinjiang , China |
Author_xml | – sequence: 1 givenname: Nong surname: Li fullname: Li, Nong organization: Department of Endocrinology and Metabolism, the Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Karamay, Xinjiang, China – sequence: 2 givenname: Weiting surname: Xang fullname: Xang, Weiting organization: Department of Endocrinology and Metabolism, the Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Karamay, Xinjiang, China – sequence: 3 givenname: Shengli surname: Wu fullname: Wu, Shengli organization: Department of Endocrinology and Metabolism, the Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Karamay, Xinjiang, China – sequence: 4 givenname: Danting surname: Li fullname: Li, Danting organization: Department of Health Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China – sequence: 5 givenname: Min surname: Chang fullname: Chang, Min organization: Department of Health Management Center, the Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Karamay, Xinjiang, China – sequence: 6 givenname: ChengYao surname: Xie fullname: Xie, ChengYao organization: Department of Health Management Center, the Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Karamay, Xinjiang, China – sequence: 7 givenname: Mei Yu surname: Zhang fullname: Zhang, Mei Yu organization: Department of Health Management Center, the Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Karamay, Xinjiang, China – sequence: 8 givenname: Huiwen surname: Tan fullname: Tan, Huiwen organization: Department of Endocrinology Metabolism, West China Hospital of Sichuan University, Chengdu, China |
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Keywords | visceral fat obesity nonalcoholic fatty liver disease cohort study type 2 diabetes risk factor |
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Snippet | We aimed to explore the metabolic features of lean nonalcoholic fatty liver disease (Lean-NAFLD) and its association with the risk of incident type 2 diabetes... Aims We aimed to explore the metabolic features of lean nonalcoholic fatty liver disease (Lean-NAFLD) and its association with the risk of incident type 2... AimsWe aimed to explore the metabolic features of lean nonalcoholic fatty liver disease (Lean-NAFLD) and its association with the risk of incident type 2... |
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SubjectTerms | China - epidemiology cohort study Diabetes Mellitus, Type 2 - epidemiology Endocrinology Female Follow-Up Studies Humans Male Middle Aged Non-alcoholic Fatty Liver Disease - epidemiology nonalcoholic fatty liver disease Obesity - complications Obesity - epidemiology Overweight - complications Overweight - epidemiology Retrospective Studies risk factor type 2 diabetes Uric Acid visceral fat obesity |
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Title | Association between the lean nonalcoholic fatty liver disease and risk of incident type 2 diabetes in a healthy population of Northwest China: a retrospective cohort study with a 2-year follow-up period |
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