IGF2BP1 accelerates the aerobic glycolysis to boost its immune escape in hepatocellular carcinoma microenvironment

• Published in: Frontiers in immunology Vol. 15; p. 1480834
• Main Authors: Ye, Xuxing, Lin, Junmei, Chen, Yanping, Wang, Xiaobo
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.11.2024
• Subjects: Adenosine - analogs & derivatives; Adenosine - metabolism; aerobic glycolysis; Animals; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell Line, Tumor; Drug Resistance, Neoplasm - genetics; Drug Resistance, Neoplasm - immunology; Gene Expression Regulation, Neoplastic; Glycolysis; hepatocellular carcinoma; Humans; immune escape; Immunology; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Mice; N 6 -methyladenosine; Oxaliplatin - pharmacology; PD-L1; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Tumor Escape; Tumor Microenvironment - immunology; PD-L1; immune escape; N 6 -methyladenosine; aerobic glycolysis; hepatocellular carcinoma

Energy metabolism abnormity emerges as a crucial factor that facilitates tumorigenesis by accelerating aerobic glycolysis. However, the function of N -methyladenosine (m A) on hepatocellular carcinoma (HCC) aerobic glycolysis and immune escape is still unclear. Here, this investigation was intended...