Systemic and local immunosuppression in glioblastoma and its prognostic significance

• Published in: Frontiers in immunology Vol. 15; p. 1326753
• Main Authors: Stepanenko, Aleksei A., Sosnovtseva, Anastasiia O., Valikhov, Marat P., Chernysheva, Anastasia A., Abramova, Olga V., Pavlov, Konstantin A., Chekhonin, Vladimir P.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.02.2024
• Subjects: Glioblastoma; Glioma; Humans; Immunology; Immunosuppression Therapy; Inflammation; Killer Cells, Natural; lymphopenia; macrophages; myeloid-derived suppressor cells; natural killer cells; Prognosis; regulatory T cells; natural killer cells; macrophages; neutrophil-to-lymphocyte ratio; glioblastoma; glioma; lymphopenia; myeloid-derived suppressor cells

The effectiveness of tumor therapy, especially immunotherapy and oncolytic virotherapy, critically depends on the activity of the host immune cells. However, various local and systemic mechanisms of immunosuppression operate in cancer patients. Tumor-associated immunosuppression involves deregulatio...