Bacterial growth and ceftriaxone activity in individual ascitic fluids in an in vitro model of spontaneous bacterial peritonitis

• Published in: Frontiers in pharmacology Vol. 14; p. 1124821
• Main Authors: van Os, Wisse, Wulkersdorfer, Beatrix, Eberl, Sabine, Oesterreicher, Zoe, Schwabl, Philipp, Reiberger, Thomas, Paternostro, Rafael, Weber, Maria, Willinger, Birgit, Zeitlinger, Markus
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.03.2023
• Subjects: ascites; ascitic fluid; bacterial growth; ceftriaxone; Pharmacology; spontaneous bacterial peritonitis; time-kill; ceftriaxone; target site; ascites; time-kill; ascitic fluid; spontaneous bacterial peritonitis; pharmacokinetics-pharmacodynamics; bacterial growth

Introduction: The environment of the infection site affects bacterial growth and antibiotic activity. When bacterial growth and antibiotic activity are studied in body fluids, samples of multiple subjects are usually pooled, averaging out potentially relevant differences in composition. The ascitic...