Detection and analysis of endogenous polar volatile organic compounds (PVOCs) in urine for human exposome research

• Published in: Biomarkers Vol. 24; no. 3; pp. 240 - 248
• Main Authors: O'Lenick, Cassandra R., Pleil, Joachim D., Stiegel, Matthew A., Sobus, Jon R., Wallace, M. Ariel Geer
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.04.2019
• Subjects: Adult; adverse outcome pathways; Biomarkers; Environmental Exposure; Environmental Monitoring; Female; Gas Chromatography-Mass Spectrometry; gas chromatography/mass spectroscopy; human exposome; Humans; Male; Middle Aged; non-targeted analysis; urinary metabolites; Volatile Organic Compounds - chemistry; Volatile Organic Compounds - urine; Young Adult; Biomarkers; gas chromatography/mass spectroscopy; adverse outcome pathways; non-targeted analysis; human exposome; urinary metabolites

Background: The human exposome, defined as '...everything that is not the genome', comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE) interactions that can cause long-term latency and chronic diseases. The exposome constantly...