Detection and analysis of endogenous polar volatile organic compounds (PVOCs) in urine for human exposome research

Background: The human exposome, defined as '...everything that is not the genome', comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE) interactions that can cause long-term latency and chronic diseases. The exposome constantly...

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Published inBiomarkers Vol. 24; no. 3; pp. 240 - 248
Main Authors O'Lenick, Cassandra R., Pleil, Joachim D., Stiegel, Matthew A., Sobus, Jon R., Wallace, M. Ariel Geer
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.04.2019
Subjects
Adult
adverse outcome pathways
Biomarkers
Environmental Exposure
Environmental Monitoring
Female
Gas Chromatography-Mass Spectrometry
gas chromatography/mass spectroscopy
human exposome
Humans
Male
Middle Aged
non-targeted analysis
urinary metabolites
Volatile Organic Compounds - chemistry
Volatile Organic Compounds - urine
Young Adult
Biomarkers
gas chromatography/mass spectroscopy
adverse outcome pathways
non-targeted analysis
human exposome
urinary metabolites
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Abstract Background: The human exposome, defined as '...everything that is not the genome', comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE) interactions that can cause long-term latency and chronic diseases. The exposome constantly changes in response to external exposures and internal metabolism. Different types of compounds are found in different biological media. Objective: Measure polar volatile organic compounds (PVOCs) excreted in urine to document endogenous metabolites and exogenous compounds from environmental exposures. Methods: Use headspace collection and sorbent tube thermal desorption coupled with bench-top gas chromatography-mass spectrometry (GC-MS) for targeted and non-targeted approaches. Identify and categorize PVOCs that may distinguish among healthy and affected individuals. Results: Method is successfully demonstrated to tabulate a series of 28 PVOCs detected in human urine across 120 samples from 28 human subjects. Median concentrations range from below detect to 165 ng/mL. Certain PVOCs have potential health implications. Conclusions: Headspace collection with sorbent tubes is an effective method for documenting PVOCs in urine that are otherwise difficult to measure. This methodology can provide probative information regarding biochemical processes and adverse outcome pathways (AOPs) for toxicity testing.
AbstractList The human exposome, defined as ' ', comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE) interactions that can cause long-term latency and chronic diseases. The exposome constantly changes in response to external exposures and internal metabolism. Different types of compounds are found in different biological media. Measure polar volatile organic compounds (PVOCs) excreted in urine to document endogenous metabolites and exogenous compounds from environmental exposures. Use headspace collection and sorbent tube thermal desorption coupled with bench-top gas chromatography-mass spectrometry (GC-MS) for targeted and non-targeted approaches. Identify and categorize PVOCs that may distinguish among healthy and affected individuals. Method is successfully demonstrated to tabulate a series of 28 PVOCs detected in human urine across 120 samples from 28 human subjects. Median concentrations range from below detect to 165 ng/mL. Certain PVOCs have potential health implications. Headspace collection with sorbent tubes is an effective method for documenting PVOCs in urine that are otherwise difficult to measure. This methodology can provide probative information regarding biochemical processes and adverse outcome pathways (AOPs) for toxicity testing.
Background: The human exposome, defined as '...everything that is not the genome', comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE) interactions that can cause long-term latency and chronic diseases. The exposome constantly changes in response to external exposures and internal metabolism. Different types of compounds are found in different biological media. Objective: Measure polar volatile organic compounds (PVOCs) excreted in urine to document endogenous metabolites and exogenous compounds from environmental exposures. Methods: Use headspace collection and sorbent tube thermal desorption coupled with bench-top gas chromatography-mass spectrometry (GC-MS) for targeted and non-targeted approaches. Identify and categorize PVOCs that may distinguish among healthy and affected individuals. Results: Method is successfully demonstrated to tabulate a series of 28 PVOCs detected in human urine across 120 samples from 28 human subjects. Median concentrations range from below detect to 165 ng/mL. Certain PVOCs have potential health implications. Conclusions: Headspace collection with sorbent tubes is an effective method for documenting PVOCs in urine that are otherwise difficult to measure. This methodology can provide probative information regarding biochemical processes and adverse outcome pathways (AOPs) for toxicity testing.
Background: The human exposome, defined as '…everything that is not the genome', comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE) interactions that can cause long-term latency and chronic diseases. The exposome constantly changes in response to external exposures and internal metabolism. Different types of compounds are found in different biological media. Objective: Measure polar volatile organic compounds (PVOCs) excreted in urine to document endogenous metabolites and exogenous compounds from environmental exposures. Methods: Use headspace collection and sorbent tube thermal desorption coupled with bench-top gas chromatography-mass spectrometry (GC-MS) for targeted and non-targeted approaches. Identify and categorize PVOCs that may distinguish among healthy and affected individuals. Results: Method is successfully demonstrated to tabulate a series of 28 PVOCs detected in human urine across 120 samples from 28 human subjects. Median concentrations range from below detect to 165 ng/mL. Certain PVOCs have potential health implications. Conclusions: Headspace collection with sorbent tubes is an effective method for documenting PVOCs in urine that are otherwise difficult to measure. This methodology can provide probative information regarding biochemical processes and adverse outcome pathways (AOPs) for toxicity testing.Background: The human exposome, defined as '…everything that is not the genome', comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE) interactions that can cause long-term latency and chronic diseases. The exposome constantly changes in response to external exposures and internal metabolism. Different types of compounds are found in different biological media. Objective: Measure polar volatile organic compounds (PVOCs) excreted in urine to document endogenous metabolites and exogenous compounds from environmental exposures. Methods: Use headspace collection and sorbent tube thermal desorption coupled with bench-top gas chromatography-mass spectrometry (GC-MS) for targeted and non-targeted approaches. Identify and categorize PVOCs that may distinguish among healthy and affected individuals. Results: Method is successfully demonstrated to tabulate a series of 28 PVOCs detected in human urine across 120 samples from 28 human subjects. Median concentrations range from below detect to 165 ng/mL. Certain PVOCs have potential health implications. Conclusions: Headspace collection with sorbent tubes is an effective method for documenting PVOCs in urine that are otherwise difficult to measure. This methodology can provide probative information regarding biochemical processes and adverse outcome pathways (AOPs) for toxicity testing.
Author Stiegel, Matthew A.
Wallace, M. Ariel Geer
O'Lenick, Cassandra R.
Pleil, Joachim D.
Sobus, Jon R.
AuthorAffiliation b U.S. Environmental Protection Agency, Exposure Methods and Measurements Division, NERL/ORD, Research Triangle Park, NC, USA
a National Center for Atmospheric Research, Boulder, CO, USA
c Duke University Medical Center, Durham, NC, USA
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– name: c Duke University Medical Center, Durham, NC, USA
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gas chromatography/mass spectroscopy
adverse outcome pathways
non-targeted analysis
human exposome
urinary metabolites
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Snippet Background: The human exposome, defined as '...everything that is not the genome', comprises all chemicals in the body interacting with life processes. The...
The human exposome, defined as ' ', comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE)...
Background: The human exposome, defined as '…everything that is not the genome', comprises all chemicals in the body interacting with life processes. The...
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SubjectTerms Adult
adverse outcome pathways
Biomarkers
Environmental Exposure
Environmental Monitoring
Female
Gas Chromatography-Mass Spectrometry
gas chromatography/mass spectroscopy
human exposome
Humans
Male
Middle Aged
non-targeted analysis
urinary metabolites
Volatile Organic Compounds - chemistry
Volatile Organic Compounds - urine
Young Adult
Title Detection and analysis of endogenous polar volatile organic compounds (PVOCs) in urine for human exposome research
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