Multivalent Group A Streptococcal Vaccine Elicits Bactericidal Antibodies against Variant M Subtypes

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Published inClinical and Diagnostic Laboratory Immunology Vol. 12; no. 7; pp. 833 - 836
Main Authors Dale, James B., Penfound, Thomas, Chiang, Edna Y., Long, Valerie, Shulman, Stanford T., Beall, Bernard
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.07.2005
Subjects
Amino Acid Sequence
Animals
Antibodies, Bacterial - immunology
Antigens, Bacterial - immunology
Epitopes - immunology
Microbial Immunology
Molecular Sequence Data
Rabbits
Serum Bactericidal Test
Streptococcal Infections - immunology
Streptococcal Infections - prevention & control
Streptococcal Vaccines - administration & dosage
Streptococcal Vaccines - immunology
Streptococcus
Streptococcus - immunology
Online AccessGet full text
ISSN1556-6811
1071-412X
1556-679X
1098-6588
DOI10.1128/CDLI.12.7.833-836.2005

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Abstract Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CVI About CVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 1556-6811 Online ISSN: 1556-679X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to CVI .asm.org, visit: CVI       
AbstractList Group A streptococci cause a wide spectrum of clinical illness. One of several strategies for vaccine prevention of these infections is based on the type-specific M protein epitopes. A multivalent M protein-based vaccine containing type-specific determinants from 26 different M serotypes is now in clinical trials. Recent epidemiologic studies have shown that, within some serotypes, the amino-terminal M protein sequence may show natural variation, giving rise to subtypes. This raises the possibility that vaccine-induced antibodies against the parent type may not be as effective in promoting bactericidal killing of variant subtypes. In the present study we used rabbit antisera against the 26-valent M protein-based vaccine in bactericidal tests against M1, M3, and M5 streptococci, which were represented by multiple subtypes. We show that the vaccine antibodies effectively promoted in vitro bactericidal activity despite the fact that the M proteins contained naturally occurring variant sequences in the regions corresponding to the vaccine sequence. Our results show that the variant M proteins generally do not result in significant differences in opsonization promoted by rabbit antisera raised against the 26-valent vaccine, suggesting that a multivalent M protein vaccine may not permit variant subtypes of group A streptococci to escape in a highly immunized population.
Group A streptococci cause a wide spectrum of clinical illness. One of several strategies for vaccine prevention of these infections is based on the type-specific M protein epitopes. A multivalent M protein-based vaccine containing type-specific determinants from 26 different M serotypes is now in clinical trials. Recent epidemiologic studies have shown that, within some serotypes, the amino-terminal M protein sequence may show natural variation, giving rise to subtypes. This raises the possibility that vaccine-induced antibodies against the parent type may not be as effective in promoting bactericidal killing of variant subtypes. In the present study we used rabbit antisera against the 26-valent M protein-based vaccine in bactericidal tests against M1, M3, and M5 streptococci, which were represented by multiple subtypes. We show that the vaccine antibodies effectively promoted in vitro bactericidal activity despite the fact that the M proteins contained naturally occurring variant sequences in the regions corresponding to the vaccine sequence. Our results show that the variant M proteins generally do not result in significant differences in opsonization promoted by rabbit antisera raised against the 26-valent vaccine, suggesting that a multivalent M protein vaccine may not permit variant subtypes of group A streptococci to escape in a highly immunized population.Group A streptococci cause a wide spectrum of clinical illness. One of several strategies for vaccine prevention of these infections is based on the type-specific M protein epitopes. A multivalent M protein-based vaccine containing type-specific determinants from 26 different M serotypes is now in clinical trials. Recent epidemiologic studies have shown that, within some serotypes, the amino-terminal M protein sequence may show natural variation, giving rise to subtypes. This raises the possibility that vaccine-induced antibodies against the parent type may not be as effective in promoting bactericidal killing of variant subtypes. In the present study we used rabbit antisera against the 26-valent M protein-based vaccine in bactericidal tests against M1, M3, and M5 streptococci, which were represented by multiple subtypes. We show that the vaccine antibodies effectively promoted in vitro bactericidal activity despite the fact that the M proteins contained naturally occurring variant sequences in the regions corresponding to the vaccine sequence. Our results show that the variant M proteins generally do not result in significant differences in opsonization promoted by rabbit antisera raised against the 26-valent vaccine, suggesting that a multivalent M protein vaccine may not permit variant subtypes of group A streptococci to escape in a highly immunized population.
Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CVI About CVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 1556-6811 Online ISSN: 1556-679X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to CVI .asm.org, visit: CVI       
Author Bernard Beall
Edna Y. Chiang
James B. Dale
Thomas Penfound
Stanford T. Shulman
Valerie Long
AuthorAffiliation Department of Veterans Affairs, and, 1 Department of Medicine, 2 Department of Molecular Sciences, The University of Tennessee Health Science Center, Memphis, Tennessee, 3 Department of Pediatrics, Feinberg School of Medicine, Northwestern University, and Division of Infectious Diseases, Children's Memorial Hospital, Chicago, Illinois, 4 Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 5
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Corresponding author. Mailing address: 1030 Jefferson Avenue (11A), Memphis, TN 38104. Phone: (901) 577-7207. Fax: (901) 448-8231. E-mail: james.dale@med.va.gov.
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Snippet Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
Group A streptococci cause a wide spectrum of clinical illness. One of several strategies for vaccine prevention of these infections is based on the...
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SubjectTerms Amino Acid Sequence
Animals
Antibodies, Bacterial - immunology
Antigens, Bacterial - immunology
Epitopes - immunology
Microbial Immunology
Molecular Sequence Data
Rabbits
Serum Bactericidal Test
Streptococcal Infections - immunology
Streptococcal Infections - prevention & control
Streptococcal Vaccines - administration & dosage
Streptococcal Vaccines - immunology
Streptococcus
Streptococcus - immunology
Title Multivalent Group A Streptococcal Vaccine Elicits Bactericidal Antibodies against Variant M Subtypes
URI http://cvi.asm.org/content/12/7/833.abstract
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