CD133 as a marker for cancer stem cells: progresses and concerns

• Published in: Stem cells and development Vol. 18; no. 8; p. 1127
• Main Authors: Wu, Yaojiong, Wu, Philip Yuguang
• Format: Journal Article
• Language: English
• Published: United States 01.10.2009
• Subjects: AC133 Antigen; Animals; Antigens, CD - chemistry; Antigens, CD - metabolism; Biomarkers, Tumor - metabolism; Cell Separation; Glycoproteins - chemistry; Glycoproteins - metabolism; Humans; Neoplastic Stem Cells - metabolism; Organ Specificity; Peptides - chemistry; Peptides - metabolism

Increasing evidence supports the cancer stem cell hypothesis, which postulates that cancer stem cells are responsible for tumor initiation, metastasis, and resistance to treatments. Therefore, they are the cells to target to cure a cancer. To study the behavior of cancer stem cells, markers for pros...