Trematocine-derived antimicrobial peptides from the Antarctic fish Trematomus bernacchaii: potent antibacterial agents against ESKAPE pathogens

• Published in: Frontiers in microbiology Vol. 15; p. 1447301
• Main Authors: Squitieri, Damiano, Massaro, Federica, Graziano, Monica Mollica, Borocci, Stefano, Cacaci, Margherita, Di Vito, Maura, Porcelli, Fernando, Rosato, Roberto, Ceccacci, Francesca, Sanguinetti, Maurizio, Buonocore, Francesco, Bugli, Francesca
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.08.2024
• Subjects: antimicrobial peptides; antimicrobial resistance; ESKAPE pathogens; membranolytic agents; Microbiology; multi-drug resistant bacteria; membranolytic agents; ESKAPE pathogens; antimicrobial resistance; antimicrobial peptides; multi-drug resistant bacteria

This study investigated the interaction with membrane mimetic systems (LUVs), bacterial membranes, the CD spectra, and the bactericidal activity of two designed trematocine mutants, named Trem-HK and Trem-HSK. Mutants were constructed from the scaffold of Trematocine (Trem), a natural 22-amino acid...