The platelet transcriptome and proteome in Alzheimer's disease and aging: an exploratory cross-sectional study

• Published in: Frontiers in molecular biosciences Vol. 10; p. 1196083
• Main Authors: de Sousa, Diana M Bessa, Poupardin, Rodolphe, Villeda, Saul A, Schroer, Adam B, Fröhlich, Thomas, Frey, Vanessa, Staffen, Wolfgang, Mrowetz, Heike, Altendorfer, Barbara, Unger, Michael S, Iglseder, Bernhard, Paulweber, Bernhard, Trinka, Eugen, Cadamuro, Janne, Drerup, Martin, Schallmoser, Katharina, Aigner, Ludwig, Kniewallner, Kathrin M
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.06.2023
• Subjects: aging; Alzheimer’s disease; Molecular Biosciences; platelets; proteomics; transcriptomics; transcriptomics; aging; Alzheimer’s disease; proteomics; platelets

Alzheimer's disease (AD) and aging are associated with platelet hyperactivity. However, the mechanisms underlying abnormal platelet function in AD and aging are yet poorly understood. To explore the molecular profile of AD and aged platelets, we investigated platelet activation (i.e., CD62P exp...