Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study
Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study ( = 845...
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Published in | Nutrients Vol. 9; no. 4; p. 379 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Abstract | Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study (
= 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1-SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: β (SE) = -2.56 (0.96); SQ4: -2.16 (1.06)) and women (SQ1: -1.10 (0.52); SQ4: -1.28 (0.50)) (all
≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (-0.40 (0.1)), (both
≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25(OH)D had worse TUG times initially, but the rate of TUG decline was not affected. Low baseline 25(OH)D may contribute to muscle strength decline in the very old and particularly in men. |
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AbstractList | Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study (n = 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1-SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: β (SE) = −2.56 (0.96); SQ4: −2.16 (1.06)) and women (SQ1: −1.10 (0.52); SQ4: −1.28 (0.50)) (all p ≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (−0.40 (0.1)), (both p ≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25(OH)D had worse TUG times initially, but the rate of TUG decline was not affected. Low baseline 25(OH)D may contribute to muscle strength decline in the very old and particularly in men. Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study ( n = 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1–SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: β (SE) = −2.56 (0.96); SQ4: −2.16 (1.06)) and women (SQ1: −1.10 (0.52); SQ4: −1.28 (0.50)) (all p ≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (−0.40 (0.1)), (both p ≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25(OH)D had worse TUG times initially, but the rate of TUG decline was not affected. Low baseline 25(OH)D may contribute to muscle strength decline in the very old and particularly in men. Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study ( = 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1-SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: β (SE) = -2.56 (0.96); SQ4: -2.16 (1.06)) and women (SQ1: -1.10 (0.52); SQ4: -1.28 (0.50)) (all ≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (-0.40 (0.1)), (both ≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25(OH)D had worse TUG times initially, but the rate of TUG decline was not affected. Low baseline 25(OH)D may contribute to muscle strength decline in the very old and particularly in men. |
Author | Granic, Antoneta Sayer, Avan A Adamson, Ashley Siervo, Mario Davies, Karen Jagger, Carol Mathers, John C Hill, Tom R Kirkwood, Thomas B L |
AuthorAffiliation | 6 Institute for Health and Society, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne NE2 4AX, UK 3 Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK; carol.jagger@newcastle.ac.uk (C.J.); ashley.adamson@newcastle.ac.uk (A.A.); mario.siervo@newcastle.ac.uk (M.S.); tom.kirkwood@newcastle.ac.uk (T.B.L.K.); john.mathers@newcastle.ac.uk (J.C.M.) 5 School of Agriculture, Food and Rural Development, Kings Road, Newcastle University, Newcastle upon Tyne NE1 7RU, UK 4 Human Nutrition Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK; tom.hill@newcastle.ac.uk 8 Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK 1 Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; antoneta.granic@newcastle.ac.uk (A.G.); karen.davies@newcastle.ac.uk (K.D.) 2 NIHR Newcastle Biomedical Research Centre, Newcastle |
AuthorAffiliation_xml | – name: 2 NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK – name: 7 Institute of Cellular Medicine, Newcastle University, William Leech Building, Newcastle upon Tyne NE2 4HH, UK – name: 1 Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; antoneta.granic@newcastle.ac.uk (A.G.); karen.davies@newcastle.ac.uk (K.D.) – name: 6 Institute for Health and Society, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne NE2 4AX, UK – name: 8 Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK – name: 5 School of Agriculture, Food and Rural Development, Kings Road, Newcastle University, Newcastle upon Tyne NE1 7RU, UK – name: 3 Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK; carol.jagger@newcastle.ac.uk (C.J.); ashley.adamson@newcastle.ac.uk (A.A.); mario.siervo@newcastle.ac.uk (M.S.); tom.kirkwood@newcastle.ac.uk (T.B.L.K.); john.mathers@newcastle.ac.uk (J.C.M.) – name: 4 Human Nutrition Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK; tom.hill@newcastle.ac.uk |
Author_xml | – sequence: 1 givenname: Antoneta surname: Granic fullname: Granic, Antoneta email: antoneta.granic@newcastle.ac.uk, antoneta.granic@newcastle.ac.uk, antoneta.granic@newcastle.ac.uk organization: Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. antoneta.granic@newcastle.ac.uk – sequence: 2 givenname: Tom R surname: Hill fullname: Hill, Tom R email: tom.hill@newcastle.ac.uk, tom.hill@newcastle.ac.uk organization: School of Agriculture, Food and Rural Development, Kings Road, Newcastle University, Newcastle upon Tyne NE1 7RU, UK. tom.hill@newcastle.ac.uk – sequence: 3 givenname: Karen surname: Davies fullname: Davies, Karen email: karen.davies@newcastle.ac.uk, karen.davies@newcastle.ac.uk, karen.davies@newcastle.ac.uk organization: Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. karen.davies@newcastle.ac.uk – sequence: 4 givenname: Carol surname: Jagger fullname: Jagger, Carol email: carol.jagger@newcastle.ac.uk, carol.jagger@newcastle.ac.uk organization: Institute for Health and Society, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne NE2 4AX, UK. carol.jagger@newcastle.ac.uk – sequence: 5 givenname: Ashley surname: Adamson fullname: Adamson, Ashley email: ashley.adamson@newcastle.ac.uk, ashley.adamson@newcastle.ac.uk, ashley.adamson@newcastle.ac.uk organization: Institute for Health and Society, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne NE2 4AX, UK. ashley.adamson@newcastle.ac.uk – sequence: 6 givenname: Mario surname: Siervo fullname: Siervo, Mario email: mario.siervo@newcastle.ac.uk, mario.siervo@newcastle.ac.uk, mario.siervo@newcastle.ac.uk organization: Institute of Cellular Medicine, Newcastle University, William Leech Building, Newcastle upon Tyne NE2 4HH, UK. mario.siervo@newcastle.ac.uk – sequence: 7 givenname: Thomas B L surname: Kirkwood fullname: Kirkwood, Thomas B L email: tom.kirkwood@newcastle.ac.uk, tom.kirkwood@newcastle.ac.uk organization: Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. tom.kirkwood@newcastle.ac.uk – sequence: 8 givenname: John C surname: Mathers fullname: Mathers, John C email: john.mathers@newcastle.ac.uk, john.mathers@newcastle.ac.uk, john.mathers@newcastle.ac.uk organization: Institute of Cellular Medicine, Newcastle University, William Leech Building, Newcastle upon Tyne NE2 4HH, UK. john.mathers@newcastle.ac.uk – sequence: 9 givenname: Avan A surname: Sayer fullname: Sayer, Avan A email: avan.sayer@newcastle.ac.uk, avan.sayer@newcastle.ac.uk, avan.sayer@newcastle.ac.uk organization: Newcastle University Institute for Ageing, Newcastle upon Tyne NE4 5PL, UK. avan.sayer@newcastle.ac.uk |
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Keywords | muscle strength 25(OH)D physical performance grip strength Timed Up-and-Go Test very old adults |
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Snippet | Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85)... |
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SubjectTerms | 25-Hydroxyvitamin D 25-Hydroxyvitamin D 2 - blood Adults Aged, 80 and over Calcifediol - blood Cohort Studies Dietary Supplements Disease Progression Elder Nutritional Physiological Phenomena Female Grip strength Humans Longitudinal Studies Male Muscle Strength Nutritional Status Prospective Studies Psychomotor Performance Risk Sarcopenia - epidemiology Sarcopenia - physiopathology Sarcopenia - prevention & control Seasons Self Report Sex Factors United Kingdom - epidemiology Vitamin D Vitamin D - therapeutic use Vitamin D Deficiency - blood Vitamin D Deficiency - diet therapy Vitamin D Deficiency - epidemiology Vitamin D Deficiency - physiopathology |
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Title | Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study |
URI | https://www.ncbi.nlm.nih.gov/pubmed/28406464 https://www.proquest.com/docview/1899817948/abstract/ https://search.proquest.com/docview/1887414352 https://pubmed.ncbi.nlm.nih.gov/PMC5409718 |
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