LncRNA MALAT1/microRNA-30b axis regulates macrophage polarization and function

• Published in: Frontiers in immunology Vol. 14; p. 1214810
• Main Authors: Ahmad, Imran, Naqvi, Raza Ali, Valverde, Araceli, Naqvi, Afsar R.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.10.2023
• Subjects: Animals; Escherichia coli - genetics; Humans; Immunology; Lipopolysaccharides; lncRNA-miRNA interaction; long noncoding RNA; macrophage polarization; Macrophages - metabolism; MALAT1; Mice; microRNA; MicroRNAs; miRNA sponge; RNA, Long Noncoding - metabolism; miRNA sponge; phagocytosis; miR-30b; long noncoding RNA; lncRNA-miRNA interaction; macrophage polarization; microRNA; MALAT1

Macrophages (Mφ) are long-lived myeloid cells that can polarize towards the proinflammatory M1 or proresolving M2 phenotype to control diverse biological processes such as inflammation, tissue damage, and regeneration. Noncoding RNA are a class of nonprotein-coding transcriptome with numerous interd...