Arsenic methylation and lung and bladder cancer in a case-control study in northern Chile

• Published in: Toxicology and applied pharmacology Vol. 274; no. 2; pp. 225 - 231
• Main Authors: Melak, Dawit, Ferreccio, Catterina, Kalman, David, Parra, Roxana, Acevedo, Johanna, Pérez, Liliana, Cortés, Sandra, Smith, Allan H., Yuan, Yan, Liaw, Jane, Steinmaus, Craig
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 15.01.2014; Elsevier
• Subjects: 60 APPLIED LIFE SCIENCES; Aged; ARSENIC; Arsenic - metabolism; Arsenic - toxicity; Arsenic - urine; Biological and medical sciences; BLADDER; Cancer; Carcinogenesis, carcinogens and anticarcinogens; Case-Control Studies; Chemical agents; Chemical and industrial products toxicology. Toxic occupational diseases; CHILE; Chile - epidemiology; CONCENTRATION RATIO; DRINKING WATER; Drinking Water - analysis; Female; Humans; IN VITRO; Lung; Lung Neoplasms - epidemiology; Lung Neoplasms - pathology; LUNGS; Male; Medical sciences; METABOLISM; METABOLITES; Metals and various inorganic compounds; METHYLATION; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); NEOPLASMS; Odds Ratio; Pneumology; Risk Factors; Surveys and Questionnaires; TOXICITY; Toxicology; Tumors; Tumors of the respiratory system and mediastinum; Urinary Bladder Neoplasms - epidemiology; Urinary Bladder Neoplasms - pathology; Water; Water Pollutants - metabolism; Water Pollutants - toxicity; Water Pollutants - urine; South America; Chile; America; Water; Bladder; Arsenic; Methylation; Lung; Cancer; Human; Lung disease; Urinary system disease; Respiratory disease; Lung cancer; Urinary tract disease; Case control study; Malignant tumor; Respiratory system; Epidemiology; Bladder cancer; Bronchopulmonary; Carcinogen; Urinary system; Urinary bladder; Bronchus disease; Bladder disease; Public health

In humans, ingested inorganic arsenic is metabolized to monomethylarsenic (MMA) then to dimethylarsenic (DMA), although this process is not complete in most people. The trivalent form of MMA is highly toxic in vitro and previous studies have identified associations between the proportion of urinary...