Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism

• Published in: Diabetes (New York, N.Y.) Vol. 65; no. 12; pp. 3585 - 3597
• Main Authors: Gurley, Jami M, Ilkayeva, Olga, Jackson, Robert M, Griesel, Beth A, White, Phillip, Matsuzaki, Satochi, Qaisar, Rizwan, Van Remmen, Holly, Humphries, Kenneth M, Newgard, Christopher B, Olson, Ann Louise
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.12.2016
• Subjects: Amino acids; Amino Acids - metabolism; Animals; Biological Transport - physiology; Blotting, Western; Carnitine O-Palmitoyltransferase - genetics; Carnitine O-Palmitoyltransferase - metabolism; Glucose; Glucose - metabolism; Glucose Transporter Type 4 - genetics; Glucose Transporter Type 4 - metabolism; Glycogen - metabolism; Humans; Insulin resistance; Lipid Metabolism - genetics; Lipid Metabolism - physiology; Male; Metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria - metabolism; Musculoskeletal system; Obesity; Obesity - genetics; Obesity - metabolism; Rodents; Triglycerides - metabolism

Impaired GLUT4-dependent glucose uptake is a contributing factor in the development of whole-body insulin resistance in obese patients and obese animal models. Previously, we demonstrated that transgenic mice engineered to express the human GLUT4 gene under the control of the human GLUT4 promoter (i...