H19 lncRNA Promotes Skeletal Muscle Insulin Sensitivity in Part by Targeting AMPK

• Published in: Diabetes (New York, N.Y.) Vol. 67; no. 11; pp. 2183 - 2198
• Main Authors: Geng, Tingting, Liu, Ya, Xu, Yetao, Jiang, Ying, Zhang, Na, Wang, Zhangsheng, Carmichael, Gordon G., Taylor, Hugh S., Li, Da, Huang, Yingqun
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.11.2018
• Subjects: Ablation; Adenylate Kinase - metabolism; Animals; Body Composition - physiology; Down-Regulation; Energy metabolism; Epigenetics; Glucose; Glucose Clamp Technique; High fat diet; Homeostasis; Humans; Insulin; Insulin resistance; Insulin Resistance - physiology; Lipid peroxidation; Metabolism; Mice; Mice, Knockout; Mitochondria; Muscle Fibers, Skeletal - metabolism; Muscle, Skeletal - metabolism; Oxidation; Phosphoprotein Phosphatases - genetics; Phosphoprotein Phosphatases - metabolism; Post-transcription; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Skeletal muscle; Skeletal system

Skeletal muscle plays a pivotal role in regulating systemic glucose homeostasis in part through the conserved cellular energy sensor AMPK. AMPK activation increases glucose uptake, lipid oxidation, and mitochondrial biogenesis, leading to enhanced muscle insulin sensitivity and whole-body energy met...