Deciphering the roles of caveolin in neurodegenerative diseases: The good, the bad and the importance of context
•The basic knowledge regarding NDDs and caveolin family, and the characterization and function of caveolins in CNS were introduced.•On one hand, we discussed the protective role of caveolins, especially Cav-1, in the pathogenesis and development of NDDs, including AD and PD.•On the other hand, we al...
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| Published in | Ageing research reviews Vol. 62; p. 101116 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier B.V
01.09.2020
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| Online Access | Get full text |
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| Abstract | •The basic knowledge regarding NDDs and caveolin family, and the characterization and function of caveolins in CNS were introduced.•On one hand, we discussed the protective role of caveolins, especially Cav-1, in the pathogenesis and development of NDDs, including AD and PD.•On the other hand, we also summarized the unfavorable role of Cav-1 in the development of AD and PD.•Several promising alternative interventions, including gene or cell therapy and pharmacotherapy treatments targeting caveolins network, which can be useful for drug design and clinical therapy, were summarized.•This review highlighted recent advances and provided a comprehensive summary of caveolins in the development and treatment of NDDs.
Neurodegenerative diseases (NDDs), which contribute to progressive and irreversible impairments of both the structure and function of the nervous system, pose a substantial socioeconomic burden on society. Mitochondrial dysfunction, oxidative stress, membrane damage, DNA damage, and abnormal protein degradation pathways play pivotal roles in the etiology of NDDs. Recently, growing evidence has demonstrated that caveolins are important in the pathology of NDDs due to their cellular functions in signal transduction, endocytosis, transcytosis, cholesterol transport, and lipid homeostasis. Given the significance of caveolins, here we review the literature to clarify their molecular mechanisms and roles in NDDs. We first briefly introduce the general background on caveolins. Next, we focus on the various important functions of caveolins in the brain. Finally, we emphasize recent progress regarding caveolins, especially Cav-1, which exert both benefit and unfavorable effects in NDDs such as AD and PD. Collectively, the data presented here should advance the investigation of caveolins for the future development of innovative strategies for the treatment of NDDs. |
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| AbstractList | Neurodegenerative diseases (NDDs), which contribute to progressive and irreversible impairments of both the structure and function of the nervous system, pose a substantial socioeconomic burden on society. Mitochondrial dysfunction, oxidative stress, membrane damage, DNA damage, and abnormal protein degradation pathways play pivotal roles in the etiology of NDDs. Recently, growing evidence has demonstrated that caveolins are important in the pathology of NDDs due to their cellular functions in signal transduction, endocytosis, transcytosis, cholesterol transport, and lipid homeostasis. Given the significance of caveolins, here we review the literature to clarify their molecular mechanisms and roles in NDDs. We first briefly introduce the general background on caveolins. Next, we focus on the various important functions of caveolins in the brain. Finally, we emphasize recent progress regarding caveolins, especially Cav-1, which exert both benefit and unfavorable effects in NDDs such as AD and PD. Collectively, the data presented here should advance the investigation of caveolins for the future development of innovative strategies for the treatment of NDDs. Neurodegenerative diseases (NDDs), which contribute to progressive and irreversible impairments of both the structure and function of the nervous system, pose a substantial socioeconomic burden on society. Mitochondrial dysfunction, oxidative stress, membrane damage, DNA damage, and abnormal protein degradation pathways play pivotal roles in the etiology of NDDs. Recently, growing evidence has demonstrated that caveolins are important in the pathology of NDDs due to their cellular functions in signal transduction, endocytosis, transcytosis, cholesterol transport, and lipid homeostasis. Given the significance of caveolins, here we review the literature to clarify their molecular mechanisms and roles in NDDs. We first briefly introduce the general background on caveolins. Next, we focus on the various important functions of caveolins in the brain. Finally, we emphasize recent progress regarding caveolins, especially Cav-1, which exert both benefit and unfavorable effects in NDDs such as AD and PD. Collectively, the data presented here should advance the investigation of caveolins for the future development of innovative strategies for the treatment of NDDs.Neurodegenerative diseases (NDDs), which contribute to progressive and irreversible impairments of both the structure and function of the nervous system, pose a substantial socioeconomic burden on society. Mitochondrial dysfunction, oxidative stress, membrane damage, DNA damage, and abnormal protein degradation pathways play pivotal roles in the etiology of NDDs. Recently, growing evidence has demonstrated that caveolins are important in the pathology of NDDs due to their cellular functions in signal transduction, endocytosis, transcytosis, cholesterol transport, and lipid homeostasis. Given the significance of caveolins, here we review the literature to clarify their molecular mechanisms and roles in NDDs. We first briefly introduce the general background on caveolins. Next, we focus on the various important functions of caveolins in the brain. Finally, we emphasize recent progress regarding caveolins, especially Cav-1, which exert both benefit and unfavorable effects in NDDs such as AD and PD. Collectively, the data presented here should advance the investigation of caveolins for the future development of innovative strategies for the treatment of NDDs. •The basic knowledge regarding NDDs and caveolin family, and the characterization and function of caveolins in CNS were introduced.•On one hand, we discussed the protective role of caveolins, especially Cav-1, in the pathogenesis and development of NDDs, including AD and PD.•On the other hand, we also summarized the unfavorable role of Cav-1 in the development of AD and PD.•Several promising alternative interventions, including gene or cell therapy and pharmacotherapy treatments targeting caveolins network, which can be useful for drug design and clinical therapy, were summarized.•This review highlighted recent advances and provided a comprehensive summary of caveolins in the development and treatment of NDDs. Neurodegenerative diseases (NDDs), which contribute to progressive and irreversible impairments of both the structure and function of the nervous system, pose a substantial socioeconomic burden on society. Mitochondrial dysfunction, oxidative stress, membrane damage, DNA damage, and abnormal protein degradation pathways play pivotal roles in the etiology of NDDs. Recently, growing evidence has demonstrated that caveolins are important in the pathology of NDDs due to their cellular functions in signal transduction, endocytosis, transcytosis, cholesterol transport, and lipid homeostasis. Given the significance of caveolins, here we review the literature to clarify their molecular mechanisms and roles in NDDs. We first briefly introduce the general background on caveolins. Next, we focus on the various important functions of caveolins in the brain. Finally, we emphasize recent progress regarding caveolins, especially Cav-1, which exert both benefit and unfavorable effects in NDDs such as AD and PD. Collectively, the data presented here should advance the investigation of caveolins for the future development of innovative strategies for the treatment of NDDs. |
| ArticleNumber | 101116 |
| Author | Yang, Wenwen Geng, Chenhui Shi, Wenzhen Xu, Baoping Tian, Ye Yang, Yang Yang, Zhi |
| Author_xml | – sequence: 1 givenname: Wenwen surname: Yang fullname: Yang, Wenwen organization: Department of Medical Research Center, Xi’an No. 3 Hospital, The Affiliated Hospital of Northwest University, 10 Fengcheng Three Road, Xi’an 710021, China – sequence: 2 givenname: Chenhui surname: Geng fullname: Geng, Chenhui organization: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Life of Sciences, Northwest University, 229 Taibai North Road, Xi’an, 710069, China – sequence: 3 givenname: Zhi surname: Yang fullname: Yang, Zhi organization: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Life of Sciences, Northwest University, 229 Taibai North Road, Xi’an, 710069, China – sequence: 4 givenname: Baoping surname: Xu fullname: Xu, Baoping organization: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Life of Sciences, Northwest University, 229 Taibai North Road, Xi’an, 710069, China – sequence: 5 givenname: Wenzhen surname: Shi fullname: Shi, Wenzhen organization: Department of Medical Research Center, Xi’an No. 3 Hospital, The Affiliated Hospital of Northwest University, 10 Fengcheng Three Road, Xi’an 710021, China – sequence: 6 givenname: Yang surname: Yang fullname: Yang, Yang email: yang200214yy@163.com, chhty@sina.com organization: Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Life of Sciences, Northwest University, 229 Taibai North Road, Xi’an, 710069, China – sequence: 7 givenname: Ye surname: Tian fullname: Tian, Ye email: chhty@sina.com organization: Department of Medical Research Center, Xi’an No. 3 Hospital, The Affiliated Hospital of Northwest University, 10 Fengcheng Three Road, Xi’an 710021, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32554058$$D View this record in MEDLINE/PubMed |
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| Snippet | •The basic knowledge regarding NDDs and caveolin family, and the characterization and function of caveolins in CNS were introduced.•On one hand, we discussed... Neurodegenerative diseases (NDDs), which contribute to progressive and irreversible impairments of both the structure and function of the nervous system, pose... |
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| SubjectTerms | Caveolin Caveolin 1 - metabolism Cerebrum functions Endocytosis Homeostasis Humans Neurodegenerative Diseases Oxidative Stress Signal Transduction |
| Title | Deciphering the roles of caveolin in neurodegenerative diseases: The good, the bad and the importance of context |
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