Exploring the potential common denominator pathogenesis of system lupus erythematosus with COVID-19 based on comprehensive bioinformatics analysis
Evidences show that there may be a link between SLE and COVID-19. The purpose of this study is to screen out the diagnostic biomarkers of systemic lupus erythematosus (SLE) with COVID-19 and explore the possible related mechanisms by the bioinformatics approach. SLE and COVID-19 datasets were extrac...
Saved in:
| Published in | Frontiers in immunology Vol. 14; p. 1179664 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
22.06.2023
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-3224 1664-3224 |
| DOI | 10.3389/fimmu.2023.1179664 |
Cover
| Abstract | Evidences show that there may be a link between SLE and COVID-19. The purpose of this study is to screen out the diagnostic biomarkers of systemic lupus erythematosus (SLE) with COVID-19 and explore the possible related mechanisms by the bioinformatics approach.
SLE and COVID-19 datasets were extracted separately from the NCBI Gene Expression Omnibus (GEO) database. The limma package in
was used to obtain the differential genes (DEGs). The protein interaction network information (PPI) and core functional modules were constructed in the STRING database using Cytoscape software. The hub genes were identified by the Cytohubba plugin, and TF-gene together with TF-miRNA regulatory networks were constructed
utilizing the Networkanalyst platform. Subsequently, we generated subject operating characteristic curves (ROC) to verify the diagnostic capabilities of these hub genes to predict the risk of SLE with COVID-19 infection. Finally, a single-sample gene set enrichment (ssGSEA) algorithm was used to analyze immune cell infiltration.
A total of 6 common hub genes (
, and
) were identified with high diagnostic validity. These gene functional enrichments were mainly involved in cell cycle, and inflammation-related pathways. Compared to the healthy controls, abnormal infiltration of immune cells was found in SLE and COVID-19, and the proportion of immune cells linked to the 6 hub genes.
Our research logically identified 6 candidate hub genes that could predict SLE complicated with COVID-19. This work provides a foothold for further study of potential pathogenesis in SLE and COVID-19. |
|---|---|
| AbstractList | ObjectiveEvidences show that there may be a link between SLE and COVID-19. The purpose of this study is to screen out the diagnostic biomarkers of systemic lupus erythematosus (SLE) with COVID-19 and explore the possible related mechanisms by the bioinformatics approach.MethodsSLE and COVID-19 datasets were extracted separately from the NCBI Gene Expression Omnibus (GEO) database. The limma package in R was used to obtain the differential genes (DEGs). The protein interaction network information (PPI) and core functional modules were constructed in the STRING database using Cytoscape software. The hub genes were identified by the Cytohubba plugin, and TF-gene together with TF-miRNA regulatory networks were constructed via utilizing the Networkanalyst platform. Subsequently, we generated subject operating characteristic curves (ROC) to verify the diagnostic capabilities of these hub genes to predict the risk of SLE with COVID-19 infection. Finally, a single-sample gene set enrichment (ssGSEA) algorithm was used to analyze immune cell infiltration.ResultsA total of 6 common hub genes (CDC6, PLCG1, KIF15, LCK, CDC25C, and RASGRP1) were identified with high diagnostic validity. These gene functional enrichments were mainly involved in cell cycle, and inflammation-related pathways. Compared to the healthy controls, abnormal infiltration of immune cells was found in SLE and COVID-19, and the proportion of immune cells linked to the 6 hub genes.ConclusionOur research logically identified 6 candidate hub genes that could predict SLE complicated with COVID-19. This work provides a foothold for further study of potential pathogenesis in SLE and COVID-19. Evidences show that there may be a link between SLE and COVID-19. The purpose of this study is to screen out the diagnostic biomarkers of systemic lupus erythematosus (SLE) with COVID-19 and explore the possible related mechanisms by the bioinformatics approach.ObjectiveEvidences show that there may be a link between SLE and COVID-19. The purpose of this study is to screen out the diagnostic biomarkers of systemic lupus erythematosus (SLE) with COVID-19 and explore the possible related mechanisms by the bioinformatics approach.SLE and COVID-19 datasets were extracted separately from the NCBI Gene Expression Omnibus (GEO) database. The limma package in R was used to obtain the differential genes (DEGs). The protein interaction network information (PPI) and core functional modules were constructed in the STRING database using Cytoscape software. The hub genes were identified by the Cytohubba plugin, and TF-gene together with TF-miRNA regulatory networks were constructed via utilizing the Networkanalyst platform. Subsequently, we generated subject operating characteristic curves (ROC) to verify the diagnostic capabilities of these hub genes to predict the risk of SLE with COVID-19 infection. Finally, a single-sample gene set enrichment (ssGSEA) algorithm was used to analyze immune cell infiltration.MethodsSLE and COVID-19 datasets were extracted separately from the NCBI Gene Expression Omnibus (GEO) database. The limma package in R was used to obtain the differential genes (DEGs). The protein interaction network information (PPI) and core functional modules were constructed in the STRING database using Cytoscape software. The hub genes were identified by the Cytohubba plugin, and TF-gene together with TF-miRNA regulatory networks were constructed via utilizing the Networkanalyst platform. Subsequently, we generated subject operating characteristic curves (ROC) to verify the diagnostic capabilities of these hub genes to predict the risk of SLE with COVID-19 infection. Finally, a single-sample gene set enrichment (ssGSEA) algorithm was used to analyze immune cell infiltration.A total of 6 common hub genes (CDC6, PLCG1, KIF15, LCK, CDC25C, and RASGRP1) were identified with high diagnostic validity. These gene functional enrichments were mainly involved in cell cycle, and inflammation-related pathways. Compared to the healthy controls, abnormal infiltration of immune cells was found in SLE and COVID-19, and the proportion of immune cells linked to the 6 hub genes.ResultsA total of 6 common hub genes (CDC6, PLCG1, KIF15, LCK, CDC25C, and RASGRP1) were identified with high diagnostic validity. These gene functional enrichments were mainly involved in cell cycle, and inflammation-related pathways. Compared to the healthy controls, abnormal infiltration of immune cells was found in SLE and COVID-19, and the proportion of immune cells linked to the 6 hub genes.Our research logically identified 6 candidate hub genes that could predict SLE complicated with COVID-19. This work provides a foothold for further study of potential pathogenesis in SLE and COVID-19.ConclusionOur research logically identified 6 candidate hub genes that could predict SLE complicated with COVID-19. This work provides a foothold for further study of potential pathogenesis in SLE and COVID-19. Evidences show that there may be a link between SLE and COVID-19. The purpose of this study is to screen out the diagnostic biomarkers of systemic lupus erythematosus (SLE) with COVID-19 and explore the possible related mechanisms by the bioinformatics approach. SLE and COVID-19 datasets were extracted separately from the NCBI Gene Expression Omnibus (GEO) database. The limma package in was used to obtain the differential genes (DEGs). The protein interaction network information (PPI) and core functional modules were constructed in the STRING database using Cytoscape software. The hub genes were identified by the Cytohubba plugin, and TF-gene together with TF-miRNA regulatory networks were constructed utilizing the Networkanalyst platform. Subsequently, we generated subject operating characteristic curves (ROC) to verify the diagnostic capabilities of these hub genes to predict the risk of SLE with COVID-19 infection. Finally, a single-sample gene set enrichment (ssGSEA) algorithm was used to analyze immune cell infiltration. A total of 6 common hub genes ( , and ) were identified with high diagnostic validity. These gene functional enrichments were mainly involved in cell cycle, and inflammation-related pathways. Compared to the healthy controls, abnormal infiltration of immune cells was found in SLE and COVID-19, and the proportion of immune cells linked to the 6 hub genes. Our research logically identified 6 candidate hub genes that could predict SLE complicated with COVID-19. This work provides a foothold for further study of potential pathogenesis in SLE and COVID-19. |
| Author | Yin, Zhihua Zeng, Huiqiong Li, Xiaojuan Huang, Xia Zhuang, Yu Peng, Haiyan |
| AuthorAffiliation | 1 Department of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Futian District , Shenzhen, Guangdong , China 3 Department of Public Health, Shenzhen Hospital of Southern Medical University , Shenzhen , China 2 Department of Rheumatology and Immunology, Huizhou Central People’s Hospital , Huizhou, Guangdong , China 4 Department of Xi Yuan Community Health Service Center, The Eighth Affiliated Hospital of Sun Yat-sen University , Shenzhen, Guangdong , China |
| AuthorAffiliation_xml | – name: 1 Department of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Futian District , Shenzhen, Guangdong , China – name: 2 Department of Rheumatology and Immunology, Huizhou Central People’s Hospital , Huizhou, Guangdong , China – name: 4 Department of Xi Yuan Community Health Service Center, The Eighth Affiliated Hospital of Sun Yat-sen University , Shenzhen, Guangdong , China – name: 3 Department of Public Health, Shenzhen Hospital of Southern Medical University , Shenzhen , China |
| Author_xml | – sequence: 1 givenname: Huiqiong surname: Zeng fullname: Zeng, Huiqiong – sequence: 2 givenname: Yu surname: Zhuang fullname: Zhuang, Yu – sequence: 3 givenname: Xiaojuan surname: Li fullname: Li, Xiaojuan – sequence: 4 givenname: Zhihua surname: Yin fullname: Yin, Zhihua – sequence: 5 givenname: Xia surname: Huang fullname: Huang, Xia – sequence: 6 givenname: Haiyan surname: Peng fullname: Peng, Haiyan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37426642$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kstu1DAUhiNURC_0BVggL9nM4Ftie4XQUMpIlboBtpbHOZm4SuxgO4V5DZ4YT2eKWhZ4c2yf_3zHl_-8OvHBQ1W9IXjJmFTvOzeO85JiypaECNU0_EV1RkpYMEr5yZP5aXWZ0h0ugyvGWP2qOmWC05KmZ9Xvq1_TEKLzW5R7QFPI4LMzA7JhHINHLfgwOm9yiGgyuQ9b8JBcQqFDaZcyjGiYpzkhiLsCGIswldVPl3u0uv2-_rQgCm1MghYVWoFOEXrwyd0D2rjgfBdiKXI2IePNsCvo19XLzgwJLo_xovr2-err6svi5vZ6vfp4s7C8UXnR1kYYACUlJoZKbA3bSNEAxRbbcjtVG0o4tpJYXnPKjbCtqIEx1VEsgLCLan3gtsHc6Sm60cSdDsbph40Qt9rEcrIBtJJYEtHVtsGUK8CqNdJy3sgOC9oqXFgfDqxp3ozQ2vKI0QzPoM8z3vV6G-41wYzWgu0J746EGH7MkLIeXbIwDMZDmJOmkjVUESFkkb592uxvl8dfLQJ5ENgYUorQaetyeeSw7-2G0lTvPaQfPKT3HtJHD5VS-k_pI_0_RX8AjKDORg |
| CitedBy_id | crossref_primary_10_1016_j_vaccine_2024_126484 crossref_primary_10_1016_j_intimp_2024_112048 crossref_primary_10_1177_09612033241309845 |
| Cites_doi | 10.1186/s13256-020-02582-8 10.3390/ijms23031716 10.1093/nar/gky311 10.1038/s41579-022-00713-0 10.1016/j.immuni.2018.03.025 10.1186/s12941-021-00438-7 10.1016/j.isci.2021.102711 10.1016/j.intimp.2021.108255 10.1016/j.autrev.2017.11.009 10.1016/j.ijbiomac.2018.12.146 10.3892/mmr.2021.11998 10.1038/nri3403 10.1038/nri3024 10.1080/08916934.2019.1631812 10.1038/s42003-022-04067-4 10.1093/rheumatology/40.2.152 10.1038/s41584-021-00741-9 10.1007/s11684-021-0906-x 10.1016/j.tim.2022.12.008 10.3389/fimmu.2021.683249 10.1136/annrheumdis-2021-221636 10.1101/2020.04.09.20059626 10.1016/j.cell.2018.01.029 10.1038/sj.onc.1205821 10.1136/annrheumdis-2020-218296 10.1016/j.autrev.2020.102524 10.7326/AITC202006020 10.3389/fimmu.2019.01066 10.3390/cells11121978 10.1016/j.beha.2022.101401 10.26355/eurrev_201908_18744 10.1038/s42003-023-04447-4 10.3390/ijms24021652 10.1007/s00296-022-05183-4 10.1016/j.biochi.2020.09.018 10.1126/science.abc8511 10.1007/s10787-022-00992-2 10.1038/s41591-020-0901-9 10.1126/science.abd4585 10.3390/cells9040915 10.3389/fimmu.2020.623944 10.3389/fimmu.2021.695242 10.1038/nature09247 10.1093/nar/gkz240 10.1186/ar2964 10.1038/nrrheum.2016.186 10.1016/j.rdc.2021.04.006 10.1136/annrheumdis-2021-eular.2809 10.1007/s12519-019-00229-3 10.1007/s10067-020-05073-9 10.1016/j.immuni.2016.06.028 10.1016/j.clim.2020.108524 10.1126/scitranslmed.aax1159 10.1007/978-1-4939-9424-3_31 10.1007/s10067-020-05301-2 10.2169/internalmedicine.40.80 10.3899/jrheum.200452 10.2217/fmb-2022-0103 10.1177/0961203308093923 10.1016/j.cell.2018.08.065 10.4049/jimmunol.1100450 10.7150/jca.57334 10.3389/fimmu.2021.789788 10.1093/bioinformatics/btt138 10.1177/0961203314531637 10.1093/bioinformatics/btp311 10.1038/nmeth.2689 10.1172/jci.insight.138999 10.1016/j.jaut.2021.102730 10.1016/j.jaut.2018.10.025 10.1681/ASN.2020060802 |
| ContentType | Journal Article |
| Copyright | Copyright © 2023 Zeng, Zhuang, Li, Yin, Huang and Peng. Copyright © 2023 Zeng, Zhuang, Li, Yin, Huang and Peng 2023 Zeng, Zhuang, Li, Yin, Huang and Peng |
| Copyright_xml | – notice: Copyright © 2023 Zeng, Zhuang, Li, Yin, Huang and Peng. – notice: Copyright © 2023 Zeng, Zhuang, Li, Yin, Huang and Peng 2023 Zeng, Zhuang, Li, Yin, Huang and Peng |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fimmu.2023.1179664 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1664-3224 |
| ExternalDocumentID | oai_doaj_org_article_980817f5c60249e09da8c4468f072d90 PMC10325730 37426642 10_3389_fimmu_2023_1179664 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: ; |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EBS EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c469t-d5a7aee98801a280ca3b876e20c0c26695a2140c81c45424a7cd75e339f207e13 |
| IEDL.DBID | M48 |
| ISSN | 1664-3224 |
| IngestDate | Wed Aug 27 01:29:12 EDT 2025 Thu Aug 21 18:37:07 EDT 2025 Thu Sep 04 20:10:12 EDT 2025 Thu Apr 03 07:03:49 EDT 2025 Tue Jul 01 03:33:29 EDT 2025 Thu Apr 24 22:51:31 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | COVID-19 immune cells infiltration diagnostic biomarkers system lupus erythematosus bioinformatics |
| Language | English |
| License | Copyright © 2023 Zeng, Zhuang, Li, Yin, Huang and Peng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c469t-d5a7aee98801a280ca3b876e20c0c26695a2140c81c45424a7cd75e339f207e13 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Meijuan Zhou, Southern Medical University, China Reviewed by: Pier Maria Fornasari, REGENHEALTHSOLUTIONS, Italy; Yukai Wang, Shantou Central Hospital, China |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fimmu.2023.1179664 |
| PMID | 37426642 |
| PQID | 2836291778 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_980817f5c60249e09da8c4468f072d90 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10325730 proquest_miscellaneous_2836291778 pubmed_primary_37426642 crossref_citationtrail_10_3389_fimmu_2023_1179664 crossref_primary_10_3389_fimmu_2023_1179664 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-06-22 |
| PublicationDateYYYYMMDD | 2023-06-22 |
| PublicationDate_xml | – month: 06 year: 2023 text: 2023-06-22 day: 22 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in immunology |
| PublicationTitleAlternate | Front Immunol |
| PublicationYear | 2023 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Kiriakidou (B5) 2020; 172 Clottu (B70) 2022; 12 Park (B53) 2023; 6 Zhang (B2) 2022; 16 Chen (B26) 2020; 47 Liao (B61) 2020; 26 Tsokos (B30) 2016; 12 Lotia (B17) 2013; 29 Shah (B71) 2010; 12 Hannawi (B39) 2021; 80 Liu (B16) 2009; 25 Franz (B18) 2018; 46 Yunis (B34) 2023; 31 Han (B48) 2019; 11 Caso (B8) 2020; 19 Griffith (B72) 2013; 10 Mathew (B33) 2020; 369 Canny (B69) 2021; 47 Curran (B46) 2019; 97 Gusev (B60) 2022; 23 Pruchniak (B67) 2019; 52 Rosetti (B42) 2022; 18 Jog (B24) 2021; 3 Hsu (B38) 2023; 24 Sabbatino (B50) 2021; 7 Kudose (B13) 2020; 31 Pablos (B10) 2020; 79 Bastard (B31) 2020; 370 Muralidar (B1) 2020; 179 Fousert (B64) 2020; 9 B3 Brownlie (B54) 2013; 13 Bonam S (B49) 2022; 17 Rada (B63) 2019; 1982 Molineros (B40) 2019; 20 Chasset (B32) 2018; 17 Piccolo (B35) 2002; 21 Niedźwiedzka-Rystwej (B51) 2022; 11 Lamers (B29) 2022; 20 Misra (B9) 2020; 39 Lambert (B19) 2018; 172 Poissonnier (B36) 2016; 45 Hasanvand (B52) 2022; 30 Mallah (B4) 2021; 20 Lee (B45) 2009; 18 Pan (B6) 2020; 16 Santos (B11) 2020; 39 Berry (B15) 2010; 466 Ghosh (B44) 2021; 12 Zamani (B12) 2021; 15 Lévy (B14) 2021; 24 Attiq (B55) 2021; 101 Raiker (B28) 2021; 125 Davitt (B59) 2022; 35 Ugarte-Gil (B27) 2022; 81 Tu (B41) 2018; 48 Villanueva (B68) 2011; 187 Mantovani (B62) 2011; 11 Nelson (B22) 2014; 23 Hsu (B23) 2001; 40 Fu (B57) 2019; 23 Kong (B56) 2019; 15 Sekigawa (B25) 2001; 40 Fatoye (B7) 2022; 42 Zuo (B66) 2020 Zuo (B65) 2020; 5 Coscia (B21) 2018; 175 Zhao (B58) 2021; 23 Zhou (B20) 2019; 47 Lin (B43) 2020; 218 Liang (B47) 2021; 5 Cheshenko (B37) 2022; 5 |
| References_xml | – volume: 15 start-page: 29 year: 2021 ident: B12 article-title: Systemic lupus erythematosus manifestation following COVID-19: a case report publication-title: J Med Case Rep doi: 10.1186/s13256-020-02582-8 – volume: 23 year: 2022 ident: B60 article-title: SARS-CoV-2-Specific immune response and the pathogenesis of COVID-19 publication-title: Int J Mol Sci doi: 10.3390/ijms23031716 – volume: 46 year: 2018 ident: B18 article-title: GeneMANIA update 2018 publication-title: Nucleic Acids Res doi: 10.1093/nar/gky311 – volume: 20 year: 2022 ident: B29 article-title: SARS-CoV-2 pathogenesis publication-title: Nat Rev Microbiol doi: 10.1038/s41579-022-00713-0 – ident: B3 – volume: 48 start-page: 745 year: 2018 ident: B41 article-title: T Cell receptor-regulated TGF-β type I receptor expression determines T cell quiescence and activation publication-title: Immunity doi: 10.1016/j.immuni.2018.03.025 – volume: 20 start-page: 35 year: 2021 ident: B4 article-title: COVID-19: breaking down a global health crisis publication-title: Ann Clin Microbiol Antimicrob doi: 10.1186/s12941-021-00438-7 – volume: 24 year: 2021 ident: B14 article-title: French COVID cohort study group. CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death publication-title: iScience doi: 10.1016/j.isci.2021.102711 – volume: 101 year: 2021 ident: B55 article-title: The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19 publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2021.108255 – volume: 17 start-page: 44 year: 2018 ident: B32 article-title: Targeting interferons and their pathways in systemic lupus erythematosus publication-title: Autoimmun Rev doi: 10.1016/j.autrev.2017.11.009 – volume: 15 year: 2019 ident: B56 article-title: TNF-α regulates microglial activation via the NF-κB signaling pathway in systemic lupus erythematosus with depression publication-title: Int J Biol Macromol doi: 10.1016/j.ijbiomac.2018.12.146 – volume: 23 start-page: 359 year: 2021 ident: B58 article-title: miR-101-3p negatively regulates inflammation in systemic lupus erythematosus via MAPK1 targeting and inhibition of the NF-κB pathway publication-title: Mol Med Rep doi: 10.3892/mmr.2021.11998 – volume: 13 year: 2013 ident: B54 article-title: T Cell receptor signalling networks: branched, diversified and bounded publication-title: Nat Rev Immunol doi: 10.1038/nri3403 – volume: 11 year: 2011 ident: B62 article-title: Neutrophils in the activation and regulation of innate and adaptive immunity publication-title: Nat Rev Immunol doi: 10.1038/nri3024 – volume: 52 year: 2019 ident: B67 article-title: Neutrophil extracellular traps generation and degradation in patients with granulomatosis with polyangiitis and systemic lupus erythematosus publication-title: Autoimmunity doi: 10.1080/08916934.2019.1631812 – volume: 5 start-page: 1096 year: 2022 ident: B37 article-title: Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2 publication-title: Commun Biol doi: 10.1038/s42003-022-04067-4 – volume: 40 year: 2001 ident: B23 article-title: Human parvovirus B19 infection in patients with systemic lupus erythematosus publication-title: Rheumatol (Oxford) doi: 10.1093/rheumatology/40.2.152 – volume: 18 year: 2022 ident: B42 article-title: Regulation of activated T cell survival in rheumatic autoimmune diseases publication-title: Nat Rev Rheumatol doi: 10.1038/s41584-021-00741-9 – volume: 16 year: 2022 ident: B2 article-title: SARS-CoV-2 variants, immune escape, and countermeasures publication-title: Front Med doi: 10.1007/s11684-021-0906-x – volume: 31 year: 2023 ident: B34 article-title: Severe respiratory viral infections: T-cell functions diverging from immunity to inflammation publication-title: Trends Microbiol doi: 10.1016/j.tim.2022.12.008 – volume: 5 year: 2021 ident: B47 article-title: Total glucosides of paeony ameliorate pristane-induced lupus nephritis by inducing PD-1 ligands+ macrophages via activating IL-4/STAT6/PD-L2 signaling publication-title: Front Immunol doi: 10.3389/fimmu.2021.683249 – volume: 81 year: 2022 ident: B27 article-title: Characteristics associated with poor COVID-19 outcomes in individuals with systemic lupus erythematosus: data from the COVID-19 global rheumatology alliance publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2021-221636 – year: 2020 ident: B66 article-title: Neutrophil extracellular traps (NETs) as markers of disease severity in COVID-19 publication-title: medRxiv doi: 10.1101/2020.04.09.20059626 – volume: 172 year: 2018 ident: B19 article-title: The human transcription factors publication-title: Cell doi: 10.1016/j.cell.2018.01.029 – volume: 21 year: 2002 ident: B35 article-title: The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration publication-title: Oncogene doi: 10.1038/sj.onc.1205821 – volume: 79 year: 2020 ident: B10 article-title: Clinical outcomes of hospitalised patients with COVID-19 and chronic inflammatory and autoimmune rheumatic diseases: a multicentric matched cohort study publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2020-218296 – volume: 19 year: 2020 ident: B8 article-title: Could sars-coronavirus-2 trigger autoimmune and/or autoinflammatory mechanisms in genetically predisposed subjects publication-title: Autoimmun Rev doi: 10.1016/j.autrev.2020.102524 – volume: 172 year: 2020 ident: B5 article-title: Systemic lupus erythematosus publication-title: Ann Intern Med doi: 10.7326/AITC202006020 – volume: 20 year: 2019 ident: B40 article-title: Mechanistic characterization of RASGRP1 variants identifies an hnRNP-K-Regulated transcriptional enhancer contributing to SLE susceptibility publication-title: Front Immunol doi: 10.3389/fimmu.2019.01066 – volume: 11 year: 2022 ident: B51 article-title: Programmed cell death-1/Programmed cell death-1 ligand as prognostic markers of coronavirus disease 2019 severity publication-title: Cells doi: 10.3390/cells11121978 – volume: 35 year: 2022 ident: B59 article-title: COVID-19 disease and immune dysregulation publication-title: Best Pract Res Clin Haematol doi: 10.1016/j.beha.2022.101401 – volume: 23 year: 2019 ident: B57 article-title: MiR-146a relieves kidney injury in mice with systemic lupus erythematosus through regulating NF-κB pathway publication-title: Eur Rev Med Pharmacol Sci doi: 10.26355/eurrev_201908_18744 – volume: 6 start-page: 76 year: 2023 ident: B53 article-title: Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity publication-title: Commun Biol doi: 10.1038/s42003-023-04447-4 – volume: 24 year: 2023 ident: B38 article-title: A focused review of ras guanine nucleotide-releasing protein 1 in immune cells and cancer publication-title: Int J Mol Sci doi: 10.3390/ijms24021652 – volume: 42 year: 2022 ident: B7 article-title: Global and regional prevalence and incidence of systemic lupus erythematosus in low-and-middle income countries: a systematic review and meta-analysis publication-title: Rheumatol Int doi: 10.1007/s00296-022-05183-4 – volume: 179 start-page: 85 year: 2020 ident: B1 article-title: The emergence of COVID-19 as a global pandemic: understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2 publication-title: Biochimie doi: 10.1016/j.biochi.2020.09.018 – volume: 369 year: 2020 ident: B33 article-title: Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications publication-title: Science doi: 10.1126/science.abc8511 – volume: 30 year: 2022 ident: B52 article-title: COVID-19 and the role of cytokines in this disease publication-title: Inflammopharmacology doi: 10.1007/s10787-022-00992-2 – volume: 26 year: 2020 ident: B61 article-title: Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 publication-title: Nat Med doi: 10.1038/s41591-020-0901-9 – volume: 370 year: 2020 ident: B31 article-title: Autoantibodies against type I IFNs in patients with life-threatening COVID-19 publication-title: Science doi: 10.1126/science.abd4585 – volume: 9 year: 2020 ident: B64 article-title: Neutrophil extracellular traps (NETs) take the central stage in driving autoimmune responses publication-title: Cells doi: 10.3390/cells9040915 – volume: 3 year: 2021 ident: B24 article-title: Epstein Barr Virus and autoimmune responses in systemic lupus erythematosus publication-title: Front Immunol doi: 10.3389/fimmu.2020.623944 – volume: 7 year: 2021 ident: B50 article-title: PD-L1 dysregulation in COVID-19 patients publication-title: Front Immunol doi: 10.3389/fimmu.2021.695242 – volume: 466 year: 2010 ident: B15 article-title: An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis publication-title: Nature doi: 10.1038/nature09247 – volume: 47 year: 2019 ident: B20 article-title: NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis publication-title: Nucleic Acids Res doi: 10.1093/nar/gkz240 – volume: 12 start-page: R53 year: 2010 ident: B71 article-title: Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus publication-title: Arthritis Res Ther doi: 10.1186/ar2964 – volume: 12 year: 2016 ident: B30 article-title: New insights into the immunopathogenesis of systemic lupus erythematosus publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2016.186 – volume: 47 start-page: 395 year: 2021 ident: B69 article-title: B cells in systemic lupus erythematosus: from disease mechanisms to targeted therapies publication-title: Rheum Dis Clin North Am doi: 10.1016/j.rdc.2021.04.006 – volume: 80 start-page: 895 year: 2021 ident: B39 article-title: POS1223 RAS GUANYL RELEASING PROTEIN 1 (RASGRP1) IN PERIPHERAL b CELLS LINKS RA TO COVID-19 publication-title: Ann Rheumatic Dis doi: 10.1136/annrheumdis-2021-eular.2809 – volume: 16 start-page: 19 year: 2020 ident: B6 article-title: Immunological pathogenesis and treatment of systemic lupus erythematosus publication-title: World J Pediatr doi: 10.1007/s12519-019-00229-3 – volume: 39 year: 2020 ident: B9 article-title: Rheumatologists’ perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets publication-title: Clin Rheumatol doi: 10.1007/s10067-020-05073-9 – volume: 45 year: 2016 ident: B36 article-title: CD95-mediated calcium signaling promotes T helper 17 trafficking to inflamed organs in lupus-prone mice publication-title: Immunity doi: 10.1016/j.immuni.2016.06.028 – volume: 218 year: 2020 ident: B43 article-title: Long-term infection of SARS-CoV-2 changed the body’s immune status publication-title: Clin Immunol doi: 10.1016/j.clim.2020.108524 – volume: 11 year: 2019 ident: B48 article-title: PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aax1159 – volume: 1982 year: 2019 ident: B63 article-title: Neutrophil extracellular traps publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-9424-3_31 – volume: 39 year: 2020 ident: B11 article-title: Determinants of COVID-19 disease severity in patients with underlying rheumatic disease publication-title: Clin Rheumatol doi: 10.1007/s10067-020-05301-2 – volume: 40 year: 2001 ident: B25 article-title: Retroviruses and autoimmunity publication-title: Intern Med doi: 10.2169/internalmedicine.40.80 – volume: 47 start-page: 1452 year: 2020 ident: B26 article-title: The plight of patients with lupus nephritis during the outbreak of COVID-19 in wuhan, China publication-title: J Rheumatol doi: 10.3899/jrheum.200452 – volume: 17 year: 2022 ident: B49 article-title: Role of the PD-1 and PD-L1 axis in COVID-19 publication-title: Future Microbiol doi: 10.2217/fmb-2022-0103 – volume: 18 start-page: 9 year: 2009 ident: B45 article-title: Association of programmed cell death 1 polymorphisms and systemic lupus erythematosus: a meta-analysis publication-title: Lupus doi: 10.1177/0961203308093923 – volume: 175 start-page: 159 year: 2018 ident: B21 article-title: Multi-level proteomics identifies CT45 as a chemosensitivity mediator and immunotherapy target in ovarian cancer publication-title: Cell doi: 10.1016/j.cell.2018.08.065 – volume: 187 year: 2011 ident: B68 article-title: Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus publication-title: J Immunol doi: 10.4049/jimmunol.1100450 – volume: 12 year: 2021 ident: B44 article-title: A snapshot of the PD-1/PD-L1 pathway publication-title: J Cancer doi: 10.7150/jca.57334 – volume: 12 year: 2022 ident: B70 article-title: Innate lymphoid cells in autoimmune diseases publication-title: Front Immunol doi: 10.3389/fimmu.2021.789788 – volume: 29 year: 2013 ident: B17 article-title: Cytoscape app store publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt138 – volume: 23 start-page: 596 year: 2014 ident: B22 article-title: Viruses as potential pathogenic agents in systemic lupus erythematosus publication-title: Lupus doi: 10.1177/0961203314531637 – volume: 25 year: 2009 ident: B16 article-title: Complex discovery from weighted PPI networks publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp311 – volume: 10 year: 2013 ident: B72 article-title: DGIdb: mining the druggable genome publication-title: Nat Methods doi: 10.1038/nmeth.2689 – volume: 5 year: 2020 ident: B65 article-title: Neutrophil extracellular traps in COVID-19 publication-title: JCI Insight doi: 10.1172/jci.insight.138999 – volume: 125 year: 2021 ident: B28 article-title: Short term outcomes of COVID-19 in lupus: propensity score matched analysis from a nationwide multi-centric research network publication-title: J Autoimmun doi: 10.1016/j.jaut.2021.102730 – volume: 97 start-page: 1 year: 2019 ident: B46 article-title: PD-1 immunobiology in systemic lupus erythematosus publication-title: J Autoimmun doi: 10.1016/j.jaut.2018.10.025 – volume: 31 year: 2020 ident: B13 article-title: Kidney biopsy findings in patients with COVID-19 publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2020060802 |
| SSID | ssj0000493335 |
| Score | 2.3654134 |
| Snippet | Evidences show that there may be a link between SLE and COVID-19. The purpose of this study is to screen out the diagnostic biomarkers of systemic lupus... ObjectiveEvidences show that there may be a link between SLE and COVID-19. The purpose of this study is to screen out the diagnostic biomarkers of systemic... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 1179664 |
| SubjectTerms | bioinformatics COVID-19 diagnostic biomarkers immune cells infiltration Immunology system lupus erythematosus |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwELYQUiUuiLY8wqNyJW4okNhxHB9h6YpWanthETfLcRxYtJusdjeH_Rv9xczE2dVuVdELx7wtz9jzffbkG0LOY9wXhAEdFsKxMCkjFeJSQ5gaJvLYFY61WzE_f6V3g-THo3hcK_WFOWFeHth33JXC0hCyFDZFcTsXqcJkFjhMVkaSFapl65GK1sjUi8e9nHPh_5IBFqauyuF43FxisXDcpwSQn2xEolaw_18o8-9kybXo098jux1spNe-uR_Jlqs-kQ--kOTiM_mzSqWjAOjopJ5jEhA8AP4EfkZhcqkx5wUINsUaxPUTTnHDGa1L6rWc6aiZNDPqpgsv41rP4AgXaWnv98P32zBWFANeQeFtmIY-dc8-9Z3mw7pTX0XFZ2o6lZN9Muh_u-_dhV21hdACRZ6DsYw0zikY0LFhWWQNz2GqBGPZyEIYV8IwYGM2i20iEpYYaQspHOeqZJF0MT8g21VduSNCc5maNOOFAq6VWJHlFqIeL3J4dwoATQYkXva8tp0UOVbEGGmgJGgt3VpLo7V0Z62AXKyemXghjjfvvkGDru5EEe32BLiW7lxL_8-1AvJ16Q4aBh3upJjK1c1MAyZLGRBdmQXk0LvH6lNcIuhJWECyDcfZaMvmlWr43Ap7o7ihgCn3-D1af0J2sEcwrY2xU7I9nzbuDADUPP_SjpVXTOIaEg priority: 102 providerName: Directory of Open Access Journals |
| Title | Exploring the potential common denominator pathogenesis of system lupus erythematosus with COVID-19 based on comprehensive bioinformatics analysis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/37426642 https://www.proquest.com/docview/2836291778 https://pubmed.ncbi.nlm.nih.gov/PMC10325730 https://doaj.org/article/980817f5c60249e09da8c4468f072d90 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9MwELbGEBIviN8EtslIvKGMxHbi-AGhbTAG0uCFor5ZjuNsRV1ckkai_wZ_MXeJW1E0EC-V2jo_mrvzfZ99_Y6QFynuC0JAx1XmWCzqRMW41BDnhmVl6irHhq2Y80_52UR8nGbTHbJudxQeYHcttcN-UpN2fvjj--oNBPxrZJyQb1_Vs6ur_hD7gOMWJOB3cYPchMyUIxk7D3D_24iGOR96bqYwKAZfFuP_aP5ymq1cNUj6X4dD_yyn_C0_nd4ldwKwpEejJ9wjO665T26NrSZXD8jPTbEdBchHF36JZUJwAHgceCKF6cdjVQxQcIpdiv0FToKzjvqajmrPdN4v-o66djUKvfoO3uEyLj35_PXD2zhVFFNiReFsWKjeusuxOJ6WMx_0WVETmpqgg_KQTE7ffTk5i0M_htgCiV6COY00zikI-dSwIrGGlzCZgjltYiHRq8ww4Gu2SK3IBBNG2kpmjnNVs0S6lD8iu41v3BNCS5mbvOCVAjYmbFaUFvIir0o4dw4QTkYkXT95bYNYOfbMmGsgLWgtPVhLo7V0sFZEXm6OWYxSHf8cfYwG3YxEme3hA99e6BC1WmFfEllnNkdlRZeoyhQWCHRRJ5JVKonI87U7aAhL3GsxjfN9pwG15QyosCwi8nh0j82luERYJFhEii3H2bqX7W-a2eUg_Y3yhxlMyk__48LPyG38wVjXxtge2V22vdsHBLUsD4aVB3h9P00PhhD5BXlsHM0 |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exploring+the+potential+common+denominator+pathogenesis+of+system+lupus+erythematosus+with+COVID-19+based+on+comprehensive+bioinformatics+analysis&rft.jtitle=Frontiers+in+immunology&rft.au=Zeng%2C+Huiqiong&rft.au=Zhuang%2C+Yu&rft.au=Li%2C+Xiaojuan&rft.au=Yin%2C+Zhihua&rft.date=2023-06-22&rft.issn=1664-3224&rft.eissn=1664-3224&rft.volume=14&rft.spage=1179664&rft_id=info:doi/10.3389%2Ffimmu.2023.1179664&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-3224&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-3224&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-3224&client=summon |