Camelid Inoculation With Middle East Respiratory Syndrome Coronavirus: Experimental Models of Reservoir Host Infection

Within the past two decades, three zoonotic betacoronaviruses have been associated with outbreaks causing severe respiratory disease in humans. Of these, Middle East respiratory s yndrome coronavirus (MERS-CoV) is the only zoonotic coronavirus that is known to consistently result in frequent zoonoti...

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Published inViruses Vol. 12; no. 12; p. 1370
Main Authors Adney, Danielle R, Clancy, Chad S, Bowen, Richard A, Munster, Vincent J
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 30.11.2020
MDPI
Subjects
Alpacas
animal coronaviruses
Animals
Antibodies
Asymptomatic
camelid
Camelus - virology
Camelus dromedarius
Coronaviridae
Coronavirus Infections - pathology
Coronavirus Infections - prevention & control
Coronavirus Infections - transmission
Coronavirus Infections - virology
coronavirus pathogenesis
Coronaviruses
COVID-19
Disease Reservoirs - virology
Disease transmission
Domestication
Epidemics
Humans
Infections
Inoculation
Laboratories
MERS-CoV
Middle East respiratory syndrome
Middle East Respiratory Syndrome Coronavirus - pathogenicity
Middle East Respiratory Syndrome Coronavirus - physiology
Milk
Models, Biological
Patients
Public health
Pulmonary arteries
Pulmonary hypertension
Respiratory diseases
Review
Severe acute respiratory syndrome coronavirus 2
Vaccination - veterinary
Virus Shedding
Zoonoses
Zoonoses - prevention & control
Zoonoses - transmission
Zoonoses - virology
Middle East
Saudi Arabia
coronavirus pathogenesis
MERS-CoV
animal coronaviruses
camelid
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Abstract Within the past two decades, three zoonotic betacoronaviruses have been associated with outbreaks causing severe respiratory disease in humans. Of these, Middle East respiratory s yndrome coronavirus (MERS-CoV) is the only zoonotic coronavirus that is known to consistently result in frequent zoonotic spillover events from the proximate reservoir host-the dromedary camel. A comprehensive understanding of infection in dromedaries is critical to informing public health recommendations and implementing intervention strategies to mitigate spillover events. Experimental models of reservoir disease are absolutely critical in understanding the pathogenesis and transmission, and are key to testing potential dromedary vaccines against MERS-CoV. In this review, we describe experimental infections of dromedary camels as well as additional camelid models used to further understand the camel's role in MERS-CoV spillover to humans.
AbstractList Within the past two decades, three zoonotic betacoronaviruses have been associated with outbreaks causing severe respiratory disease in humans. Of these, Middle East respiratory s yndrome coronavirus (MERS-CoV) is the only zoonotic coronavirus that is known to consistently result in frequent zoonotic spillover events from the proximate reservoir host—the dromedary camel. A comprehensive understanding of infection in dromedaries is critical to informing public health recommendations and implementing intervention strategies to mitigate spillover events. Experimental models of reservoir disease are absolutely critical in understanding the pathogenesis and transmission, and are key to testing potential dromedary vaccines against MERS-CoV. In this review, we describe experimental infections of dromedary camels as well as additional camelid models used to further understand the camel’s role in MERS-CoV spillover to humans.
Author Adney, Danielle R
Clancy, Chad S
Munster, Vincent J
Bowen, Richard A
AuthorAffiliation 3 Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80521, USA; rbowen@rams.colostate.edu
1 Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA; danielle.adney@nih.gov
2 Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA; chad.clancy@nih.gov
AuthorAffiliation_xml – name: 2 Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA; chad.clancy@nih.gov
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  surname: Adney
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33266124$$D View this record in MEDLINE/PubMed
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animal coronaviruses
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Snippet Within the past two decades, three zoonotic betacoronaviruses have been associated with outbreaks causing severe respiratory disease in humans. Of these,...
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SubjectTerms Alpacas
animal coronaviruses
Animals
Antibodies
Asymptomatic
camelid
Camelus - virology
Camelus dromedarius
Coronaviridae
Coronavirus Infections - pathology
Coronavirus Infections - prevention & control
Coronavirus Infections - transmission
Coronavirus Infections - virology
coronavirus pathogenesis
Coronaviruses
COVID-19
Disease Reservoirs - virology
Disease transmission
Domestication
Epidemics
Humans
Infections
Inoculation
Laboratories
MERS-CoV
Middle East respiratory syndrome
Middle East Respiratory Syndrome Coronavirus - pathogenicity
Middle East Respiratory Syndrome Coronavirus - physiology
Milk
Models, Biological
Patients
Public health
Pulmonary arteries
Pulmonary hypertension
Respiratory diseases
Review
Severe acute respiratory syndrome coronavirus 2
Vaccination - veterinary
Virus Shedding
Zoonoses
Zoonoses - prevention & control
Zoonoses - transmission
Zoonoses - virology
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Title Camelid Inoculation With Middle East Respiratory Syndrome Coronavirus: Experimental Models of Reservoir Host Infection
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Volume 12
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