Myricetin inhibits transmissible gastroenteritis virus replication by targeting papain-like protease deubiquitinating enzyme activity

• Published in: Frontiers in microbiology Vol. 15; p. 1433664
• Main Authors: Fan, Jiahao, Xi, Pengyuan, Liu, Huimao, Song, Xu, Zhao, Xinghong, Zhou, Xun, Zou, Yuanfeng, Fu, Yuping, Li, Lixia, Jia, Renyong, Yin, Zhongqiong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.07.2024
• Subjects: coronavirus; deubiquitination; Microbiology; myricetin; papain-like protease (PLpro); transmissible gastroenteritis virus (TGEV); coronavirus; deubiquitination; myricetin; papain-like protease (PLpro); transmissible gastroenteritis virus (TGEV)

Myricetin, a natural flavonoid found in various foods, was investigated for its antiviral effect against transmissible gastroenteritis virus (TGEV). This α-coronavirus causes significant economic losses in the global swine industry. The study focused on the papain-like protease (PLpro), which plays...