Epistatic interactions between Fc (GM) and FcγR genes and the host control of human immunodeficiency virus replication

• Published in: Human immunology Vol. 73; no. 3; pp. 263 - 266
• Main Authors: Deepe, Raymond N., Kistner-Griffin, Emily, Martin, Jeffrey N., Deeks, Steven G., Pandey, Janardan P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2012
• Subjects: ADCC; Adult; Allergy and Immunology; Asymptomatic Diseases; Carrier State; Chromosomes, Human, Pair 14 - genetics; Epistasis, Genetic; FcγR; Female; GM allotypes; HIV; HIV - pathogenicity; HIV - physiology; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - virology; Humans; Immunoglobulin Gm Allotypes - genetics; Immunoglobulin Km Allotypes - genetics; KM allotypes; Male; Middle Aged; Receptors, IgG - genetics; Receptors, IgG - metabolism; Virus Replication; GM allotypes; KM allotypes; HIV; FcγR; ADCC

Host genetic factors are thought to contribute to the interindividual differences in the control of human immunodeficiency virus (HIV) replication. The aim of the present investigation was to determine whether genes encoding GM and KM allotypes—genetic markers of immunoglobulin γ and κ chains, respe...