Evidence for the Contribution of the miR-206/BDNF Pathway in the Pathophysiology of Depression

• Published in: The international journal of neuropsychopharmacology Vol. 27; no. 10; p. 1
• Main Authors: Zheng, Ya-Bin, Jin, Xiang
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.10.2024
• Subjects: Animals; Brain - metabolism; Brain - physiopathology; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Cellular signal transduction; Depression - genetics; Depression - metabolism; Depression - physiopathology; Depression, Mental; Depressive Disorder - genetics; Depressive Disorder - metabolism; Depressive Disorder - physiopathology; Development and progression; DNA methylation; Humans; Mental depression; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Pathogenesis; Physiological aspects; Psychological aspects; Psychological research; Review; Signal Transduction - physiology; China; neurogenesis; Depression; depressive-like behavior; biomarker; MiRNA

Abstract Depression is a complex disorder with substantial impacts on individual health and has major public health implications. Depression results from complex interactions between genetic and environmental factors. Epigenetic mechanisms, including DNA methylation, microRNAs (miRNAs), and histone...