A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B.1.1.33 Circulating in Brazil

• Published in: Viruses Vol. 13; no. 5; p. 724
• Main Authors: Resende, Paola Cristina, Gräf, Tiago, Paixão, Anna Carolina Dias, Appolinario, Luciana, Lopes, Renata Serrano, Mendonça, Ana Carolina da Fonseca, da Rocha, Alice Sampaio Barreto, Motta, Fernando Couto, Neto, Lidio Gonçalves Lima, Khouri, Ricardo, de Oliveira, Camila I, Santos-Muccillo, Pedro, Bezerra, João Felipe, Teixeira, Dalane Loudal Florentino, Riediger, Irina, Debur, Maria do Carmo, Ribeiro-Rodrigues, Rodrigo, Leite, Anderson Brandao, do Santos, Cliomar Alves, Gregianini, Tatiana Schäffer, Fernandes, Sandra Bianchini, Bernardes, André Felipe Leal, Cavalcanti, Andrea Cony, Miyajima, Fábio, Sachhi, Claudio, Mattos, Tirza, da Costa, Cristiano Fernandes, Delatorre, Edson, Wallau, Gabriel L, Naveca, Felipe G, Bello, Gonzalo, Siqueira, Marilda Mendonça
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.04.2021; MDPI
• Subjects: Binding sites; Brazil; Communication; Coronaviruses; COVID-19; Disease transmission; E484K; Epidemiology; Genomes; genomic epidemiology; Markov analysis; Mutation; Phylogenetics; Proteins; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike protein; variant of Interest; Brazil; Brazil; variant of Interest; SARS-CoV-2; E484K; genomic epidemiology

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved...