Intestinal Metaproteomics Reveals Host-Microbiota Interactions in Subjects at Risk for Type 1 Diabetes

• Published in: Diabetes care Vol. 41; no. 10; pp. 2178 - 2186
• Main Authors: Gavin, Patrick G., Mullaney, Jane A., Loo, Dorothy, Cao, Kim-Anh Lê, Gottlieb, Peter A., Hill, Michelle M., Zipris, Danny, Hamilton-Williams, Emma E.
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.10.2018
• Subjects: Adolescent; Adult; Autoantibodies; Bacterial Proteins - physiology; Child; Child, Preschool; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - microbiology; Diabetes Mellitus, Type 1 - physiopathology; Digestive system; Dysbacteriosis; Dysbiosis - microbiology; Dysbiosis - physiopathology; Feces - microbiology; Female; Gastrointestinal Microbiome - physiology; Gastrointestinal tract; Health risks; Host-Pathogen Interactions - physiology; Humans; Inflammation - microbiology; Intestine; Intestines - physiopathology; Male; Microbiology; Microbiota; Microorganisms; Middle Aged; Mucosa; Pancreas; Pancreas - metabolism; Pancreas - physiopathology; Pathogenesis; Pathophysiology/Complications; Patients; Proteins; Proteins - physiology; Proteomics; Research design; Risk Assessment; Risk Factors; Young Adult

Dysbiosis of the gut microbiota has been linked to disease pathogenesis in type 1 diabetes, yet the functional consequences to the host of this dysbiosis are unknown. We investigated the functional interactions between the microbiota and the host associated with type 1 diabetes disease risk. We perf...