Evidence of IQ-Modulated Association Between ZNF804A Gene Polymorphism and Cognitive Function in Schizophrenia Patients

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 37; no. 7; pp. 1572 - 1578
• Main Authors: Chen, Min, Xu, Zhansheng, Zhai, Jinguo, Bao, Xin, Zhang, Qiumei, Gu, Huang, Shen, Qiuge, Cheng, Lina, Chen, Xiongying, Wang, Keqin, Deng, Xiaoxiang, Ji, Feng, Liu, Chuanxin, Li, Jun, Dong, Qi, Chen, Chuansheng
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.06.2012
• Subjects: Adult; Adult and adolescent clinical studies; Alleles; Attention task; Biological and medical sciences; Cognition; Cognition Disorders - genetics; Cognition Disorders - psychology; Cognitive ability; Data processing; Etiology; Executive function; Executive Function - physiology; Female; Gene polymorphism; Genetic Association Studies; Genetic Predisposition to Disease; Genomes; Genotype; Humans; Intelligence; Intelligence - genetics; Kruppel-Like Transcription Factors - genetics; Male; Medical sciences; Memory; Memory, Short-Term - physiology; Mental disorders; Neuropsychological Tests; Neurosciences; Original; Patients; Polymorphism; Polymorphism, Single Nucleotide; Psychiatrists; Psychologists; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Replication; Schizophrenia; Schizophrenia - genetics; Schizophrenic Psychology; Short term memory; Single-nucleotide polymorphism; Beijing China; China; Psychosis; Human; Executive function; Gene; Schizophrenia; ZNF804A; Genetics; Intellectual ability; Cognition; Working memory; Polymorphism; Intelligence quotient

ZNF804A gene polymorphism rs1344706 has been suggested as the most compelling case of a candidate gene for schizophrenia by a genome-wide association study and several replication studies. The current study of 570 schizophrenia patients and 448 controls again found significantly different genotype f...