25 Years of PI5P

• Published in: Frontiers in cell and developmental biology Vol. 11; p. 1272911
• Main Authors: Rameh, Lucia E, Blind, Raymond D
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.10.2023
• Subjects: Cell and Developmental Biology; PI(4,5)P2; PI5P; PIKfyve; PIP4K; TMEMs; PI5P; PIKfyve; TMEMs; PIP4K; PI(4,5)P2

The accidental discovery of PI5P (phosphatidylinositol-5-phosphate) was published 25 years ago, when PIP5K type II (phosphoinositide-4-phosphate 5-kinase) was shown to actually be a 4-kinase that uses PI5P as a substrate to generate PI(4,5)P . Consequently, PIP5K type II was renamed to PI5P4K, or PI...