Disease progression and survival in ALS: First multi-state model approach

• Published in: Amyotrophic lateral sclerosis Vol. 8; no. 4; pp. 224 - 229
• Main Authors: Gil, Juan, Preux, Pierre-Marie, Alioum, Ahmadou, Ketzoian, Carlos, Desport, Jean-Claude, Druet-Cabanac, Michel, Couratier, Philippe
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2007; Taylor & Francis; Elsevier
• Subjects: Age Factors; Age of Onset; Aged; Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis - diagnosis; Amyotrophic Lateral Sclerosis - epidemiology; Amyotrophic Lateral Sclerosis - mortality; Amyotrophic Lateral Sclerosis - physiopathology; Analysis of Variance; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Body Mass Index; Carcinoma, Non-Small-Cell Lung; Cohort Studies; Comorbidity; Deoxycytidine; Disease Progression; epidemiology; Female; Humans; Life Sciences; Male; Markov Chains; Middle Aged; multi-states model; Neoplasm Staging; Outcome Assessment (Health Care); Outcome Assessment (Health Care) - methods; Patient Selection; Pleural Neoplasms; prognostic factors; Respiration; Retrospective Studies; Santé publique et épidémiologie; Severity of Illness Index; Taxoids; Treatment Outcome

Although several prognostic factors have been identified in ALS, there remains some discordance concerning the prognostic significance of the age and clinical form at onset. In order to clarify these findings, we have analysed already known prognostic factors using a multi-state model. Two hundred a...