Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

• Published in: Biomicrofluidics Vol. 9; no. 5; p. 054124
• Main Authors: Brown, Jacquelyn A., Pensabene, Virginia, Markov, Dmitry A., Allwardt, Vanessa, Neely, M. Diana, Shi, Mingjian, Britt, Clayton M., Hoilett, Orlando S., Yang, Qing, Brewer, Bryson M., Samson, Philip C., McCawley, Lisa J., May, James M., Webb, Donna J., Li, Deyu, Bowman, Aaron B., Reiserer, Ronald S., Wikswo, John P.
• Format: Journal Article
• Language: English
• Published: United States American Institute of Physics 01.09.2015; AIP Publishing LLC
• Subjects: Bioreactors; Blood-brain barrier; Central nervous system; Endothelial cells; Fluorescein; Nutrients; Regular

The blood-brain barrier (BBB) is a critical structure that serves as the gatekeeper between the central nervous system and the rest of the body. It is the responsibility of the BBB to facilitate the entry of required nutrients into the brain and to exclude potentially harmful compounds; however, thi...