Overexpression of fetA (ybbL) and fetB (ybbM), Encoding an Iron Exporter, Enhances Resistance to Oxidative Stress in Escherichia coli

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Published inApplied and Environmental Microbiology Vol. 79; no. 23; pp. 7210 - 7219
Main Authors NICOLAOU, Sergios A, FAST, Alan G, NAKAMARU-OGISO, Eiko, PAPOUTSAKIS, Eleftherios T
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.12.2013
Subjects
Adenosine triphosphatase
Bacterial Outer Membrane Proteins - genetics
Bacterial Outer Membrane Proteins - metabolism
Biological and medical sciences
E coli
Environmental Microbiology
Escherichia coli - genetics
Escherichia coli - physiology
Fundamental and applied biological sciences. Psychology
Gene Expression
Homeostasis
Hydrogen Peroxide - toxicity
Iron - metabolism
Lipids
Microbiology
Oxidative Stress
Proteins
Resistance
Oxidative stress
Escherichia coli
Gene overexpression
Bacteria
Iron
Enterobacteriaceae
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Abstract Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue AEM About AEM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AEM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0099-2240 Online ISSN: 1098-5336 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AEM .asm.org, visit: AEM       
AbstractList Reactive oxygen species are generated by redox reactions and the Fenton reaction of H2O2 and iron that generates the hydroxyl radical that causes severe DNA, protein, and lipid damage. We screened Escherichia coli genomic libraries to identify a fragment, containing cueR, ybbJ, qmcA, ybbL, and ybbM, which enhanced resistance to H2O2 stress. We report that the ΔybbL and ΔybbM strains are more susceptible to H2O2 stress than the parent strain and that ybbL and ybbM overexpression overcomes H2O2 sensitivity. The ybbL and ybbM genes are predicted to code for an ATP-binding cassette metal transporter, and we demonstrate that YbbM is a membrane protein. We investigated various metals to identify iron as the likely substrate of this transporter. We propose the gene names fetA and fetB (for Fe transport) and the gene product names FetA and FetB. FetAB allows for increased resistance to oxidative stress in the presence of iron, revealing a role in iron homeostasis. We show that iron overload coupled with H2O2 stress is abrogated by fetA and fetB overexpression in the parent strain and in the Δfur strain, where iron uptake is deregulated. Furthermore, we utilized whole-cell electron paramagnetic resonance to show that intracellular iron levels in the Δfur strain are decreased by 37% by fetA and fetB overexpression. Combined, these findings show that fetA and fetB encode an iron exporter that has a role in enhancing resistance to H2O2-mediated oxidative stress and can minimize oxidative stress under conditions of iron overload and suggest that FetAB facilitates iron homeostasis to decrease oxidative stress.
ABSTRACT Reactive oxygen species are generated by redox reactions and the Fenton reaction of H 2 O 2 and iron that generates the hydroxyl radical that causes severe DNA, protein, and lipid damage. We screened Escherichia coli genomic libraries to identify a fragment, containing cueR , ybbJ , qmcA , ybbL , and ybbM , which enhanced resistance to H 2 O 2 stress. We report that the Δ ybbL and Δ ybbM strains are more susceptible to H 2 O 2 stress than the parent strain and that ybbL and ybbM overexpression overcomes H 2 O 2 sensitivity. The ybbL and ybbM genes are predicted to code for an ATP-binding cassette metal transporter, and we demonstrate that YbbM is a membrane protein. We investigated various metals to identify iron as the likely substrate of this transporter. We propose the gene names fetA and fetB (for Fe transport) and the gene product names FetA and FetB. FetAB allows for increased resistance to oxidative stress in the presence of iron, revealing a role in iron homeostasis. We show that iron overload coupled with H 2 O 2 stress is abrogated by fetA and fetB overexpression in the parent strain and in the Δ fur strain, where iron uptake is deregulated. Furthermore, we utilized whole-cell electron paramagnetic resonance to show that intracellular iron levels in the Δ fur strain are decreased by 37% by fetA and fetB overexpression. Combined, these findings show that fetA and fetB encode an iron exporter that has a role in enhancing resistance to H 2 O 2 -mediated oxidative stress and can minimize oxidative stress under conditions of iron overload and suggest that FetAB facilitates iron homeostasis to decrease oxidative stress.
Reactive oxygen species are generated by redox reactions and the Fenton reaction of H 2 O 2 and iron that generates the hydroxyl radical that causes severe DNA, protein, and lipid damage. We screened Escherichia coli genomic libraries to identify a fragment, containing cueR , ybbJ , qmcA , ybbL , and ybbM , which enhanced resistance to H 2 O 2 stress. We report that the Δ ybbL and Δ ybbM strains are more susceptible to H 2 O 2 stress than the parent strain and that ybbL and ybbM overexpression overcomes H 2 O 2 sensitivity. The ybbL and ybbM genes are predicted to code for an ATP-binding cassette metal transporter, and we demonstrate that YbbM is a membrane protein. We investigated various metals to identify iron as the likely substrate of this transporter. We propose the gene names fetA and fetB (for Fe transport) and the gene product names FetA and FetB. FetAB allows for increased resistance to oxidative stress in the presence of iron, revealing a role in iron homeostasis. We show that iron overload coupled with H 2 O 2 stress is abrogated by fetA and fetB overexpression in the parent strain and in the Δ fur strain, where iron uptake is deregulated. Furthermore, we utilized whole-cell electron paramagnetic resonance to show that intracellular iron levels in the Δ fur strain are decreased by 37% by fetA and fetB overexpression. Combined, these findings show that fetA and fetB encode an iron exporter that has a role in enhancing resistance to H 2 O 2 -mediated oxidative stress and can minimize oxidative stress under conditions of iron overload and suggest that FetAB facilitates iron homeostasis to decrease oxidative stress.
Reactive oxygen species are generated by redox reactions and the Fenton reaction of H2O2 and iron that generates the hydroxyl radical that causes severe DNA, protein, and lipid damage. We screened Escherichia coli genomic libraries to identify a fragment, containing cueR, ybbJ, qmcA, ybbL, and ybbM, which enhanced resistance to H2O2 stress. We report that the ...ybbL and ...ybbM strains are more susceptible to H2O2 stress than the parent strain and that ybbL and ybbM overexpression overcomes H2O2 sensitivity. The ybbL and ybbM genes are predicted to code for an ATP-binding cassette metal transporter, and we demonstrate that YbbM is a membrane protein. We investigated various metals to identify iron as the likely substrate of this transporter. We propose the gene names fetA and fetB (for Fe transport) and the gene product names FetA and FetB. FetAB allows for increased resistance to oxidative stress in the presence of iron, revealing a role in iron homeostasis. We show that iron overload coupled with H2O2 stress is abrogated by fetA and fetB overexpression in the parent strain and in the ...fur strain, where iron uptake is deregulated. Furthermore, we utilized whole-cell electron paramagnetic resonance to show that intracellular iron levels in the ...fur strain are decreased by 37% by fetA and fetB overexpression. Combined, these findings show that fetA and fetB encode an iron exporter that has a role in enhancing resistance to H2O2-mediated oxidative stress and can minimize oxidative stress under conditions of iron overload and suggest that FetAB facilitates iron homeostasis to decrease oxidative stress. (ProQuest: ... denotes formulae/symbols omitted.)
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Author Alan G. Fast
Eleftherios T. Papoutsakis
Eiko Nakamaru-Ogiso
Sergios A. Nicolaou
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Cites_doi 10.1016/S0168-6445(03)00055-X
10.1002/biot.201200227
10.1128/AAC.01197-12
10.1016/j.ymben.2010.03.004
10.1007/s00709-011-0360-8
10.1038/msb4100050
10.1105/tpc.108.064543
10.1073/pnas.0812808106
10.1016/j.bbamem.2007.07.026
10.1093/nar/25.17.3389
10.1111/j.1365-2958.2006.05104.x
10.1128/JB.180.6.1446-1453.1998
10.1128/JB.00382-12
10.1371/journal.pone.0051179
10.1093/bioinformatics/btm404
10.1016/j.ymben.2009.12.004
10.1006/jmbi.2000.4315
10.1073/pnas.93.24.13635
10.1128/jb.177.9.2305-2314.1995
10.1046/j.1365-2958.2001.02264.x
10.1073/pnas.1007805107
10.1016/S0022-2836(02)00849-5
10.1093/nar/gkq1143
10.1002/j.1460-2075.1982.tb01276.x
10.1073/pnas.120163297
10.1016/S0076-6879(84)05004-7
10.1093/nar/29.9.e45
10.1007/s00203-004-0739-4
10.1128/JB.00001-11
10.1186/1471-2199-12-18
10.1099/mic.0.28682-0
10.1093/nar/gkg600
10.1111/j.1365-2958.2009.06699.x
10.1046/j.1365-2958.1998.00764.x
10.1016/S0076-6879(02)49316-0
10.1146/annurev.biochem.77.061606.161055
10.1073/pnas.94.26.14326
10.1111/j.1365-313X.2004.02306.x
10.1111/j.1365-2958.2011.07611.x
10.1073/pnas.242338299
10.1093/nar/gkr817
10.1128/IAI.71.5.2656-2664.2003
10.1074/jbc.M303381200
10.1007/s10534-005-4341-2
10.1093/nar/gkq313
10.1128/AEM.07368-11
10.1128/JB.01357-06
10.1101/gad.6.12b.2646
10.1073/pnas.97.2.652
10.1046/j.1365-2818.2000.00710.x
10.1111/j.1365-2958.2005.04532.x
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Keywords Resistance
Oxidative stress
Escherichia coli
Gene overexpression
Bacteria
Iron
Enterobacteriaceae
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References e_1_3_3_50_2
e_1_3_3_16_2
e_1_3_3_18_2
e_1_3_3_39_2
e_1_3_3_12_2
e_1_3_3_37_2
e_1_3_3_14_2
e_1_3_3_35_2
e_1_3_3_33_2
e_1_3_3_54_2
e_1_3_3_10_2
e_1_3_3_31_2
e_1_3_3_52_2
e_1_3_3_40_2
McCord JM (e_1_3_3_36_2) 2001
e_1_3_3_5_2
e_1_3_3_7_2
e_1_3_3_9_2
e_1_3_3_27_2
Sambrook J (e_1_3_3_30_2) 2001
e_1_3_3_29_2
e_1_3_3_23_2
e_1_3_3_48_2
e_1_3_3_25_2
e_1_3_3_46_2
e_1_3_3_44_2
e_1_3_3_3_2
e_1_3_3_21_2
e_1_3_3_42_2
e_1_3_3_51_2
e_1_3_3_17_2
e_1_3_3_19_2
e_1_3_3_38_2
e_1_3_3_13_2
e_1_3_3_15_2
e_1_3_3_34_2
e_1_3_3_32_2
e_1_3_3_11_2
e_1_3_3_53_2
e_1_3_3_6_2
e_1_3_3_8_2
e_1_3_3_28_2
e_1_3_3_49_2
e_1_3_3_24_2
e_1_3_3_47_2
e_1_3_3_26_2
e_1_3_3_45_2
e_1_3_3_2_2
e_1_3_3_20_2
e_1_3_3_43_2
e_1_3_3_4_2
e_1_3_3_22_2
e_1_3_3_41_2
References_xml – ident: e_1_3_3_5_2
  doi: 10.1016/S0168-6445(03)00055-X
– ident: e_1_3_3_27_2
  doi: 10.1002/biot.201200227
– ident: e_1_3_3_18_2
  doi: 10.1128/AAC.01197-12
– ident: e_1_3_3_10_2
  doi: 10.1016/j.ymben.2010.03.004
– ident: e_1_3_3_19_2
  doi: 10.1007/s00709-011-0360-8
– start-page: 7.3.1
  volume-title: Current protocols in toxicology
  year: 2001
  ident: e_1_3_3_36_2
  contributor:
    fullname: McCord JM
– ident: e_1_3_3_28_2
  doi: 10.1038/msb4100050
– ident: e_1_3_3_49_2
  doi: 10.1105/tpc.108.064543
– ident: e_1_3_3_7_2
  doi: 10.1073/pnas.0812808106
– ident: e_1_3_3_13_2
  doi: 10.1016/j.bbamem.2007.07.026
– ident: e_1_3_3_37_2
  doi: 10.1093/nar/25.17.3389
– ident: e_1_3_3_45_2
  doi: 10.1111/j.1365-2958.2006.05104.x
– ident: e_1_3_3_16_2
  doi: 10.1128/JB.180.6.1446-1453.1998
– ident: e_1_3_3_52_2
  doi: 10.1128/JB.00382-12
– ident: e_1_3_3_9_2
  doi: 10.1371/journal.pone.0051179
– volume-title: Molecular cloning: a laboratory manual
  year: 2001
  ident: e_1_3_3_30_2
  contributor:
    fullname: Sambrook J
– ident: e_1_3_3_39_2
  doi: 10.1093/bioinformatics/btm404
– ident: e_1_3_3_31_2
  doi: 10.1016/j.ymben.2009.12.004
– ident: e_1_3_3_40_2
  doi: 10.1006/jmbi.2000.4315
– ident: e_1_3_3_11_2
  doi: 10.1073/pnas.93.24.13635
– ident: e_1_3_3_51_2
  doi: 10.1128/jb.177.9.2305-2314.1995
– ident: e_1_3_3_53_2
  doi: 10.1046/j.1365-2958.2001.02264.x
– ident: e_1_3_3_17_2
  doi: 10.1073/pnas.1007805107
– ident: e_1_3_3_54_2
  doi: 10.1016/S0022-2836(02)00849-5
– ident: e_1_3_3_46_2
  doi: 10.1093/nar/gkq1143
– ident: e_1_3_3_48_2
  doi: 10.1002/j.1460-2075.1982.tb01276.x
– ident: e_1_3_3_29_2
  doi: 10.1073/pnas.120163297
– ident: e_1_3_3_35_2
  doi: 10.1016/S0076-6879(84)05004-7
– ident: e_1_3_3_33_2
  doi: 10.1093/nar/29.9.e45
– ident: e_1_3_3_24_2
  doi: 10.1007/s00203-004-0739-4
– ident: e_1_3_3_4_2
  doi: 10.1128/JB.00001-11
– ident: e_1_3_3_32_2
  doi: 10.1186/1471-2199-12-18
– ident: e_1_3_3_21_2
  doi: 10.1099/mic.0.28682-0
– ident: e_1_3_3_41_2
  doi: 10.1093/nar/gkg600
– ident: e_1_3_3_6_2
  doi: 10.1111/j.1365-2958.2009.06699.x
– ident: e_1_3_3_47_2
  doi: 10.1046/j.1365-2958.1998.00764.x
– ident: e_1_3_3_43_2
  doi: 10.1016/S0076-6879(02)49316-0
– ident: e_1_3_3_3_2
  doi: 10.1146/annurev.biochem.77.061606.161055
– ident: e_1_3_3_23_2
  doi: 10.1073/pnas.94.26.14326
– ident: e_1_3_3_50_2
  doi: 10.1111/j.1365-313X.2004.02306.x
– ident: e_1_3_3_2_2
  doi: 10.1111/j.1365-2958.2011.07611.x
– ident: e_1_3_3_14_2
  doi: 10.1073/pnas.242338299
– ident: e_1_3_3_26_2
  doi: 10.1093/nar/gkr817
– ident: e_1_3_3_20_2
  doi: 10.1128/IAI.71.5.2656-2664.2003
– ident: e_1_3_3_15_2
  doi: 10.1074/jbc.M303381200
– ident: e_1_3_3_25_2
  doi: 10.1007/s10534-005-4341-2
– ident: e_1_3_3_38_2
  doi: 10.1093/nar/gkq313
– ident: e_1_3_3_8_2
  doi: 10.1128/AEM.07368-11
– ident: e_1_3_3_34_2
  doi: 10.1128/JB.01357-06
– ident: e_1_3_3_12_2
  doi: 10.1101/gad.6.12b.2646
– ident: e_1_3_3_22_2
  doi: 10.1073/pnas.97.2.652
– ident: e_1_3_3_42_2
  doi: 10.1046/j.1365-2818.2000.00710.x
– ident: e_1_3_3_44_2
  doi: 10.1111/j.1365-2958.2005.04532.x
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Reactive oxygen species are generated by redox reactions and the Fenton reaction of H2O2 and iron that generates the hydroxyl radical that causes severe DNA,...
ABSTRACT Reactive oxygen species are generated by redox reactions and the Fenton reaction of H 2 O 2 and iron that generates the hydroxyl radical that causes...
Reactive oxygen species are generated by redox reactions and the Fenton reaction of H 2 O 2 and iron that generates the hydroxyl radical that causes severe...
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SourceType Open Access Repository
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StartPage 7210
SubjectTerms Adenosine triphosphatase
Bacterial Outer Membrane Proteins - genetics
Bacterial Outer Membrane Proteins - metabolism
Biological and medical sciences
E coli
Environmental Microbiology
Escherichia coli - genetics
Escherichia coli - physiology
Fundamental and applied biological sciences. Psychology
Gene Expression
Homeostasis
Hydrogen Peroxide - toxicity
Iron - metabolism
Lipids
Microbiology
Oxidative Stress
Proteins
Title Overexpression of fetA (ybbL) and fetB (ybbM), Encoding an Iron Exporter, Enhances Resistance to Oxidative Stress in Escherichia coli
URI http://aem.asm.org/content/79/23/7210.abstract
https://www.ncbi.nlm.nih.gov/pubmed/24038693
https://www.proquest.com/docview/1449851846
https://pubmed.ncbi.nlm.nih.gov/PMC3837747
Volume 79
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