Overexpression of fetA (ybbL) and fetB (ybbM), Encoding an Iron Exporter, Enhances Resistance to Oxidative Stress in Escherichia coli
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Published in | Applied and Environmental Microbiology Vol. 79; no. 23; pp. 7210 - 7219 |
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Language | English |
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01.12.2013
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AbstractList | Reactive oxygen species are generated by redox reactions and the Fenton reaction of H2O2 and iron that generates the hydroxyl radical that causes severe DNA, protein, and lipid damage. We screened Escherichia coli genomic libraries to identify a fragment, containing cueR, ybbJ, qmcA, ybbL, and ybbM, which enhanced resistance to H2O2 stress. We report that the ΔybbL and ΔybbM strains are more susceptible to H2O2 stress than the parent strain and that ybbL and ybbM overexpression overcomes H2O2 sensitivity. The ybbL and ybbM genes are predicted to code for an ATP-binding cassette metal transporter, and we demonstrate that YbbM is a membrane protein. We investigated various metals to identify iron as the likely substrate of this transporter. We propose the gene names fetA and fetB (for Fe transport) and the gene product names FetA and FetB. FetAB allows for increased resistance to oxidative stress in the presence of iron, revealing a role in iron homeostasis. We show that iron overload coupled with H2O2 stress is abrogated by fetA and fetB overexpression in the parent strain and in the Δfur strain, where iron uptake is deregulated. Furthermore, we utilized whole-cell electron paramagnetic resonance to show that intracellular iron levels in the Δfur strain are decreased by 37% by fetA and fetB overexpression. Combined, these findings show that fetA and fetB encode an iron exporter that has a role in enhancing resistance to H2O2-mediated oxidative stress and can minimize oxidative stress under conditions of iron overload and suggest that FetAB facilitates iron homeostasis to decrease oxidative stress. ABSTRACT Reactive oxygen species are generated by redox reactions and the Fenton reaction of H 2 O 2 and iron that generates the hydroxyl radical that causes severe DNA, protein, and lipid damage. We screened Escherichia coli genomic libraries to identify a fragment, containing cueR , ybbJ , qmcA , ybbL , and ybbM , which enhanced resistance to H 2 O 2 stress. We report that the Δ ybbL and Δ ybbM strains are more susceptible to H 2 O 2 stress than the parent strain and that ybbL and ybbM overexpression overcomes H 2 O 2 sensitivity. The ybbL and ybbM genes are predicted to code for an ATP-binding cassette metal transporter, and we demonstrate that YbbM is a membrane protein. We investigated various metals to identify iron as the likely substrate of this transporter. We propose the gene names fetA and fetB (for Fe transport) and the gene product names FetA and FetB. FetAB allows for increased resistance to oxidative stress in the presence of iron, revealing a role in iron homeostasis. We show that iron overload coupled with H 2 O 2 stress is abrogated by fetA and fetB overexpression in the parent strain and in the Δ fur strain, where iron uptake is deregulated. Furthermore, we utilized whole-cell electron paramagnetic resonance to show that intracellular iron levels in the Δ fur strain are decreased by 37% by fetA and fetB overexpression. Combined, these findings show that fetA and fetB encode an iron exporter that has a role in enhancing resistance to H 2 O 2 -mediated oxidative stress and can minimize oxidative stress under conditions of iron overload and suggest that FetAB facilitates iron homeostasis to decrease oxidative stress. Reactive oxygen species are generated by redox reactions and the Fenton reaction of H 2 O 2 and iron that generates the hydroxyl radical that causes severe DNA, protein, and lipid damage. We screened Escherichia coli genomic libraries to identify a fragment, containing cueR , ybbJ , qmcA , ybbL , and ybbM , which enhanced resistance to H 2 O 2 stress. We report that the Δ ybbL and Δ ybbM strains are more susceptible to H 2 O 2 stress than the parent strain and that ybbL and ybbM overexpression overcomes H 2 O 2 sensitivity. The ybbL and ybbM genes are predicted to code for an ATP-binding cassette metal transporter, and we demonstrate that YbbM is a membrane protein. We investigated various metals to identify iron as the likely substrate of this transporter. We propose the gene names fetA and fetB (for Fe transport) and the gene product names FetA and FetB. FetAB allows for increased resistance to oxidative stress in the presence of iron, revealing a role in iron homeostasis. We show that iron overload coupled with H 2 O 2 stress is abrogated by fetA and fetB overexpression in the parent strain and in the Δ fur strain, where iron uptake is deregulated. Furthermore, we utilized whole-cell electron paramagnetic resonance to show that intracellular iron levels in the Δ fur strain are decreased by 37% by fetA and fetB overexpression. Combined, these findings show that fetA and fetB encode an iron exporter that has a role in enhancing resistance to H 2 O 2 -mediated oxidative stress and can minimize oxidative stress under conditions of iron overload and suggest that FetAB facilitates iron homeostasis to decrease oxidative stress. Reactive oxygen species are generated by redox reactions and the Fenton reaction of H2O2 and iron that generates the hydroxyl radical that causes severe DNA, protein, and lipid damage. We screened Escherichia coli genomic libraries to identify a fragment, containing cueR, ybbJ, qmcA, ybbL, and ybbM, which enhanced resistance to H2O2 stress. We report that the ...ybbL and ...ybbM strains are more susceptible to H2O2 stress than the parent strain and that ybbL and ybbM overexpression overcomes H2O2 sensitivity. The ybbL and ybbM genes are predicted to code for an ATP-binding cassette metal transporter, and we demonstrate that YbbM is a membrane protein. We investigated various metals to identify iron as the likely substrate of this transporter. We propose the gene names fetA and fetB (for Fe transport) and the gene product names FetA and FetB. FetAB allows for increased resistance to oxidative stress in the presence of iron, revealing a role in iron homeostasis. We show that iron overload coupled with H2O2 stress is abrogated by fetA and fetB overexpression in the parent strain and in the ...fur strain, where iron uptake is deregulated. Furthermore, we utilized whole-cell electron paramagnetic resonance to show that intracellular iron levels in the ...fur strain are decreased by 37% by fetA and fetB overexpression. Combined, these findings show that fetA and fetB encode an iron exporter that has a role in enhancing resistance to H2O2-mediated oxidative stress and can minimize oxidative stress under conditions of iron overload and suggest that FetAB facilitates iron homeostasis to decrease oxidative stress. (ProQuest: ... denotes formulae/symbols omitted.) Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue AEM About AEM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AEM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0099-2240 Online ISSN: 1098-5336 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AEM .asm.org, visit: AEM |
Author | Alan G. Fast Eleftherios T. Papoutsakis Eiko Nakamaru-Ogiso Sergios A. Nicolaou |
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Cites_doi | 10.1016/S0168-6445(03)00055-X 10.1002/biot.201200227 10.1128/AAC.01197-12 10.1016/j.ymben.2010.03.004 10.1007/s00709-011-0360-8 10.1038/msb4100050 10.1105/tpc.108.064543 10.1073/pnas.0812808106 10.1016/j.bbamem.2007.07.026 10.1093/nar/25.17.3389 10.1111/j.1365-2958.2006.05104.x 10.1128/JB.180.6.1446-1453.1998 10.1128/JB.00382-12 10.1371/journal.pone.0051179 10.1093/bioinformatics/btm404 10.1016/j.ymben.2009.12.004 10.1006/jmbi.2000.4315 10.1073/pnas.93.24.13635 10.1128/jb.177.9.2305-2314.1995 10.1046/j.1365-2958.2001.02264.x 10.1073/pnas.1007805107 10.1016/S0022-2836(02)00849-5 10.1093/nar/gkq1143 10.1002/j.1460-2075.1982.tb01276.x 10.1073/pnas.120163297 10.1016/S0076-6879(84)05004-7 10.1093/nar/29.9.e45 10.1007/s00203-004-0739-4 10.1128/JB.00001-11 10.1186/1471-2199-12-18 10.1099/mic.0.28682-0 10.1093/nar/gkg600 10.1111/j.1365-2958.2009.06699.x 10.1046/j.1365-2958.1998.00764.x 10.1016/S0076-6879(02)49316-0 10.1146/annurev.biochem.77.061606.161055 10.1073/pnas.94.26.14326 10.1111/j.1365-313X.2004.02306.x 10.1111/j.1365-2958.2011.07611.x 10.1073/pnas.242338299 10.1093/nar/gkr817 10.1128/IAI.71.5.2656-2664.2003 10.1074/jbc.M303381200 10.1007/s10534-005-4341-2 10.1093/nar/gkq313 10.1128/AEM.07368-11 10.1128/JB.01357-06 10.1101/gad.6.12b.2646 10.1073/pnas.97.2.652 10.1046/j.1365-2818.2000.00710.x 10.1111/j.1365-2958.2005.04532.x |
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Keywords | Resistance Oxidative stress Escherichia coli Gene overexpression Bacteria Iron Enterobacteriaceae |
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References | e_1_3_3_50_2 e_1_3_3_16_2 e_1_3_3_18_2 e_1_3_3_39_2 e_1_3_3_12_2 e_1_3_3_37_2 e_1_3_3_14_2 e_1_3_3_35_2 e_1_3_3_33_2 e_1_3_3_54_2 e_1_3_3_10_2 e_1_3_3_31_2 e_1_3_3_52_2 e_1_3_3_40_2 McCord JM (e_1_3_3_36_2) 2001 e_1_3_3_5_2 e_1_3_3_7_2 e_1_3_3_9_2 e_1_3_3_27_2 Sambrook J (e_1_3_3_30_2) 2001 e_1_3_3_29_2 e_1_3_3_23_2 e_1_3_3_48_2 e_1_3_3_25_2 e_1_3_3_46_2 e_1_3_3_44_2 e_1_3_3_3_2 e_1_3_3_21_2 e_1_3_3_42_2 e_1_3_3_51_2 e_1_3_3_17_2 e_1_3_3_19_2 e_1_3_3_38_2 e_1_3_3_13_2 e_1_3_3_15_2 e_1_3_3_34_2 e_1_3_3_32_2 e_1_3_3_11_2 e_1_3_3_53_2 e_1_3_3_6_2 e_1_3_3_8_2 e_1_3_3_28_2 e_1_3_3_49_2 e_1_3_3_24_2 e_1_3_3_47_2 e_1_3_3_26_2 e_1_3_3_45_2 e_1_3_3_2_2 e_1_3_3_20_2 e_1_3_3_43_2 e_1_3_3_4_2 e_1_3_3_22_2 e_1_3_3_41_2 |
References_xml | – ident: e_1_3_3_5_2 doi: 10.1016/S0168-6445(03)00055-X – ident: e_1_3_3_27_2 doi: 10.1002/biot.201200227 – ident: e_1_3_3_18_2 doi: 10.1128/AAC.01197-12 – ident: e_1_3_3_10_2 doi: 10.1016/j.ymben.2010.03.004 – ident: e_1_3_3_19_2 doi: 10.1007/s00709-011-0360-8 – start-page: 7.3.1 volume-title: Current protocols in toxicology year: 2001 ident: e_1_3_3_36_2 contributor: fullname: McCord JM – ident: e_1_3_3_28_2 doi: 10.1038/msb4100050 – ident: e_1_3_3_49_2 doi: 10.1105/tpc.108.064543 – ident: e_1_3_3_7_2 doi: 10.1073/pnas.0812808106 – ident: e_1_3_3_13_2 doi: 10.1016/j.bbamem.2007.07.026 – ident: e_1_3_3_37_2 doi: 10.1093/nar/25.17.3389 – ident: e_1_3_3_45_2 doi: 10.1111/j.1365-2958.2006.05104.x – ident: e_1_3_3_16_2 doi: 10.1128/JB.180.6.1446-1453.1998 – ident: e_1_3_3_52_2 doi: 10.1128/JB.00382-12 – ident: e_1_3_3_9_2 doi: 10.1371/journal.pone.0051179 – volume-title: Molecular cloning: a laboratory manual year: 2001 ident: e_1_3_3_30_2 contributor: fullname: Sambrook J – ident: e_1_3_3_39_2 doi: 10.1093/bioinformatics/btm404 – ident: e_1_3_3_31_2 doi: 10.1016/j.ymben.2009.12.004 – ident: e_1_3_3_40_2 doi: 10.1006/jmbi.2000.4315 – ident: e_1_3_3_11_2 doi: 10.1073/pnas.93.24.13635 – ident: e_1_3_3_51_2 doi: 10.1128/jb.177.9.2305-2314.1995 – ident: e_1_3_3_53_2 doi: 10.1046/j.1365-2958.2001.02264.x – ident: e_1_3_3_17_2 doi: 10.1073/pnas.1007805107 – ident: e_1_3_3_54_2 doi: 10.1016/S0022-2836(02)00849-5 – ident: e_1_3_3_46_2 doi: 10.1093/nar/gkq1143 – ident: e_1_3_3_48_2 doi: 10.1002/j.1460-2075.1982.tb01276.x – ident: e_1_3_3_29_2 doi: 10.1073/pnas.120163297 – ident: e_1_3_3_35_2 doi: 10.1016/S0076-6879(84)05004-7 – ident: e_1_3_3_33_2 doi: 10.1093/nar/29.9.e45 – ident: e_1_3_3_24_2 doi: 10.1007/s00203-004-0739-4 – ident: e_1_3_3_4_2 doi: 10.1128/JB.00001-11 – ident: e_1_3_3_32_2 doi: 10.1186/1471-2199-12-18 – ident: e_1_3_3_21_2 doi: 10.1099/mic.0.28682-0 – ident: e_1_3_3_41_2 doi: 10.1093/nar/gkg600 – ident: e_1_3_3_6_2 doi: 10.1111/j.1365-2958.2009.06699.x – ident: e_1_3_3_47_2 doi: 10.1046/j.1365-2958.1998.00764.x – ident: e_1_3_3_43_2 doi: 10.1016/S0076-6879(02)49316-0 – ident: e_1_3_3_3_2 doi: 10.1146/annurev.biochem.77.061606.161055 – ident: e_1_3_3_23_2 doi: 10.1073/pnas.94.26.14326 – ident: e_1_3_3_50_2 doi: 10.1111/j.1365-313X.2004.02306.x – ident: e_1_3_3_2_2 doi: 10.1111/j.1365-2958.2011.07611.x – ident: e_1_3_3_14_2 doi: 10.1073/pnas.242338299 – ident: e_1_3_3_26_2 doi: 10.1093/nar/gkr817 – ident: e_1_3_3_20_2 doi: 10.1128/IAI.71.5.2656-2664.2003 – ident: e_1_3_3_15_2 doi: 10.1074/jbc.M303381200 – ident: e_1_3_3_25_2 doi: 10.1007/s10534-005-4341-2 – ident: e_1_3_3_38_2 doi: 10.1093/nar/gkq313 – ident: e_1_3_3_8_2 doi: 10.1128/AEM.07368-11 – ident: e_1_3_3_34_2 doi: 10.1128/JB.01357-06 – ident: e_1_3_3_12_2 doi: 10.1101/gad.6.12b.2646 – ident: e_1_3_3_22_2 doi: 10.1073/pnas.97.2.652 – ident: e_1_3_3_42_2 doi: 10.1046/j.1365-2818.2000.00710.x – ident: e_1_3_3_44_2 doi: 10.1111/j.1365-2958.2005.04532.x |
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Reddit... Reactive oxygen species are generated by redox reactions and the Fenton reaction of H2O2 and iron that generates the hydroxyl radical that causes severe DNA,... ABSTRACT Reactive oxygen species are generated by redox reactions and the Fenton reaction of H 2 O 2 and iron that generates the hydroxyl radical that causes... Reactive oxygen species are generated by redox reactions and the Fenton reaction of H 2 O 2 and iron that generates the hydroxyl radical that causes severe... |
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SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 7210 |
SubjectTerms | Adenosine triphosphatase Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Biological and medical sciences E coli Environmental Microbiology Escherichia coli - genetics Escherichia coli - physiology Fundamental and applied biological sciences. Psychology Gene Expression Homeostasis Hydrogen Peroxide - toxicity Iron - metabolism Lipids Microbiology Oxidative Stress Proteins |
Title | Overexpression of fetA (ybbL) and fetB (ybbM), Encoding an Iron Exporter, Enhances Resistance to Oxidative Stress in Escherichia coli |
URI | http://aem.asm.org/content/79/23/7210.abstract https://www.ncbi.nlm.nih.gov/pubmed/24038693 https://www.proquest.com/docview/1449851846 https://pubmed.ncbi.nlm.nih.gov/PMC3837747 |
Volume | 79 |
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