Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)–induced interferon-β production in peripheral blood mononuclear cells of type 1 diabetes patients - Chistiakov, Dimitry A.; Voronova, Natalia V.; Savost'Anov, Kirill V.; Turakulov, Rustam I. (Human immunology, 2010)
Keywords: Adolescent; Adult; Age of Onset; Allergy and Immunology; Child; DEAD-box RNA Helicases - genetics; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Disease Progression; Enteroviral infection; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; IFIH1; Interferon-beta - biosynthesis; Interferon-beta - genetics; Interferon-Induced Helicase, IFIH1; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Leukocytes, Mononuclear - pathology; Lymphocyte Activation - genetics; Male; MDA5; Mutation - genetics; Poly I-C - immunology; Poly I-C - metabolism; Polymorphism; Polymorphism, Genetic; Risk; Russia; Type 1 diabetes; IFIH1; Type 1 diabetes; Enteroviral infection; MDA5; Polymorphism