Exosomes: The role in mammalian reproductive regulation and pregnancy-related diseases

Exosomes are a kind of extracellular vesicles that are produced and secreted by different mammalian cells. They serve as cargo proteins and can transfer different kinds of biomolecules, including proteins, lipids, and nucleic acids, which consequently act on target cells to exert different biologica...

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Published inFrontiers in physiology Vol. 14; p. 1056905
Main Authors Guo, Xing-Ru, Ma, Yun, Ma, Zi-Ming, Dai, Tian-Shu, Wei, Shi-Hao, Chu, Yuan-Kui, Dan, Xin-Gang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 10.03.2023
Subjects
embryo implantation
endocrine regulation
exosome
follicular development
Physiology
pregnancy-related diseases
follicular development
endocrine regulation
exosome
embryo implantation
pregnancy-related diseases
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Abstract Exosomes are a kind of extracellular vesicles that are produced and secreted by different mammalian cells. They serve as cargo proteins and can transfer different kinds of biomolecules, including proteins, lipids, and nucleic acids, which consequently act on target cells to exert different biological effects. Recent years have witnessed a significant increase in the number of studies on exosomes due to the potential effects of exosomes in the diagnosis and treatment of cancers, neurodegenerative diseases, and immune disorders. Previous studies have demonstrated that exosomal contents, especially miRNAs, are implicated in numerous physiological processes such as reproduction, and are crucial regulators of mammalian reproduction and pregnancy-related diseases. Here, we describe the origin, composition, and intercellular communication of exosomes, and discuss their functions in follicular development, early embryonic development, embryonic implantation, male reproduction and development of pregnancy-related diseases in humans and animals. We believe this study will provide a foundation for revealing the mechanism of exosomes in regulating mammalian reproduction, and providing new approaches and ideas for the diagnosis and treatment of pregnancy-related diseases.
AbstractList Exosomes are a kind of extracellular vesicles that are produced and secreted by different mammalian cells. They serve as cargo proteins and can transfer different kinds of biomolecules, including proteins, lipids, and nucleic acids, which consequently act on target cells to exert different biological effects. Recent years have witnessed a significant increase in the number of studies on exosomes due to the potential effects of exosomes in the diagnosis and treatment of cancers, neurodegenerative diseases, and immune disorders. Previous studies have demonstrated that exosomal contents, especially miRNAs, are implicated in numerous physiological processes such as reproduction, and are crucial regulators of mammalian reproduction and pregnancy-related diseases. Here, we describe the origin, composition, and intercellular communication of exosomes, and discuss their functions in follicular development, early embryonic development, embryonic implantation, male reproduction and development of pregnancy-related diseases in humans and animals. We believe this study will provide a foundation for revealing the mechanism of exosomes in regulating mammalian reproduction, and providing new approaches and ideas for the diagnosis and treatment of pregnancy-related diseases.
Author Wei, Shi-Hao
Dai, Tian-Shu
Ma, Zi-Ming
Guo, Xing-Ru
Ma, Yun
Chu, Yuan-Kui
Dan, Xin-Gang
AuthorAffiliation 1 School of Agriculture , Ningxia University , Yinchuan , Ningxia , China
2 Department of Laboratory Medicine , General Hospital of Ningxia Medical University , Ningxia Medical University , Yinchuan , China
AuthorAffiliation_xml – name: 2 Department of Laboratory Medicine , General Hospital of Ningxia Medical University , Ningxia Medical University , Yinchuan , China
– name: 1 School of Agriculture , Ningxia University , Yinchuan , Ningxia , China
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  surname: Dan
  fullname: Dan, Xin-Gang
  organization: School of Agriculture, Ningxia University, Yinchuan, Ningxia, China
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Keywords follicular development
endocrine regulation
exosome
embryo implantation
pregnancy-related diseases
Language English
License Copyright © 2023 Guo, Ma, Ma, Dai, Wei, Chu and Dan.
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Beatrice Aramini, University of Bologna, Italy
Edited by: Jean Feugang, Mississippi State University, United States
This article was submitted to Reproductive and Mating Physiology, a section of the journal Frontiers in Physiology
Reviewed by: Laura Alessandra Favetta, University of Guelph, Canada
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Snippet Exosomes are a kind of extracellular vesicles that are produced and secreted by different mammalian cells. They serve as cargo proteins and can transfer...
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SubjectTerms embryo implantation
endocrine regulation
exosome
follicular development
Physiology
pregnancy-related diseases
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Title Exosomes: The role in mammalian reproductive regulation and pregnancy-related diseases
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