Exosomes: The role in mammalian reproductive regulation and pregnancy-related diseases

Exosomes are a kind of extracellular vesicles that are produced and secreted by different mammalian cells. They serve as cargo proteins and can transfer different kinds of biomolecules, including proteins, lipids, and nucleic acids, which consequently act on target cells to exert different biologica...

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Published inFrontiers in physiology Vol. 14; p. 1056905
Main Authors Guo, Xing-Ru, Ma, Yun, Ma, Zi-Ming, Dai, Tian-Shu, Wei, Shi-Hao, Chu, Yuan-Kui, Dan, Xin-Gang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 10.03.2023
Subjects
embryo implantation
endocrine regulation
exosome
follicular development
Physiology
pregnancy-related diseases
follicular development
endocrine regulation
exosome
embryo implantation
pregnancy-related diseases
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Summary:Exosomes are a kind of extracellular vesicles that are produced and secreted by different mammalian cells. They serve as cargo proteins and can transfer different kinds of biomolecules, including proteins, lipids, and nucleic acids, which consequently act on target cells to exert different biological effects. Recent years have witnessed a significant increase in the number of studies on exosomes due to the potential effects of exosomes in the diagnosis and treatment of cancers, neurodegenerative diseases, and immune disorders. Previous studies have demonstrated that exosomal contents, especially miRNAs, are implicated in numerous physiological processes such as reproduction, and are crucial regulators of mammalian reproduction and pregnancy-related diseases. Here, we describe the origin, composition, and intercellular communication of exosomes, and discuss their functions in follicular development, early embryonic development, embryonic implantation, male reproduction and development of pregnancy-related diseases in humans and animals. We believe this study will provide a foundation for revealing the mechanism of exosomes in regulating mammalian reproduction, and providing new approaches and ideas for the diagnosis and treatment of pregnancy-related diseases.
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Beatrice Aramini, University of Bologna, Italy
Edited by: Jean Feugang, Mississippi State University, United States
This article was submitted to Reproductive and Mating Physiology, a section of the journal Frontiers in Physiology
Reviewed by: Laura Alessandra Favetta, University of Guelph, Canada
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2023.1056905