Inhibitory effect of aloperine on transient outward potassium currents in rat cardiac myocytes

• Published in: Frontiers in pharmacology Vol. 15; p. 1372973
• Main Authors: Dong, Xiao-Na, Li, Meng-Ting
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.03.2024
• Subjects: aloperine; atrial fibrillation; molecular docking; Pharmacology; transient outward potassium current; whole-cell patch-clamp; atrial fibrillation; aloperine; molecular docking; whole-cell patch-clamp; transient outward potassium current

Aloperine (ALO) is an effective quinolizidine alkaloid. Previous research has demonstrated its antiarrhythmic effect by inhibiting voltage-gated sodium currents in rat ventricular myocytes. This study explored its effect on transient outward potassium currents (I ) in rat atrial myocytes to identify...