Mutation bias can shape adaptation in large asexual populations experiencing clonal interference

• Published in: Proceedings of the Royal Society. B, Biological sciences Vol. 287; no. 1937; p. 20201503
• Main Authors: Gomez, Kevin, Bertram, Jason, Masel, Joanna
• Format: Journal Article
• Language: English
• Published: England The Royal Society 28.10.2020
• Subjects: Adaptation, Physiological - genetics; Evolution; Genetics, Population; Mutation; Mutation Rate; Reproduction, Asexual - genetics; developmental bias; mutation-driven adaptation; modern synthesis; standard evolutionary theory; parallel adaptation; elasticity

The extended evolutionary synthesis invokes a role for development in shaping adaptive evolution, which in population genetics terms corresponds to mutation-biased adaptation. Critics have claimed that clonal interference makes mutation-biased adaptation rare. We consider the behaviour of two simult...