Combined Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat of Metabolic Disease: A Review
Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive rese...
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Published in | Nutrients Vol. 14; no. 22; p. 4774 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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11.11.2022
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Abstract | Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive research suggests that diet alongside physical exercise interventions exert beneficial effects on metabolic diseases by regulating gut microbiota, involving in the changes of the energy metabolism, immune regulation, and the microbial-derived metabolites.
In this review, we present the latest evidence in the modulating role of diet and physical exercise in the gut microbiota and its relevance to metabolic diseases. We also summarize the research from animal and human studies on improving metabolic diseases through diet-plus-exercise interventions, and new targeted therapies that might provide a better understanding of the potential mechanisms.
A systematic and comprehensive literature search was performed in PubMed/Medline and Web of Science in October 2022. The key terms used in the searches included "combined physical exercise and diet", "physical exercise, diet and gut microbiota", "physical exercise, diet and metabolic diseases" and "physical exercise, diet, gut microbiota and metabolic diseases".
Combined physical exercise and diet offer a more efficient approach for preventing metabolic diseases via the modification of gut microbiota, abating the burden related to longevity. |
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AbstractList | Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive research suggests that diet alongside physical exercise interventions exert beneficial effects on metabolic diseases by regulating gut microbiota, involving in the changes of the energy metabolism, immune regulation, and the microbial-derived metabolites.
In this review, we present the latest evidence in the modulating role of diet and physical exercise in the gut microbiota and its relevance to metabolic diseases. We also summarize the research from animal and human studies on improving metabolic diseases through diet-plus-exercise interventions, and new targeted therapies that might provide a better understanding of the potential mechanisms.
A systematic and comprehensive literature search was performed in PubMed/Medline and Web of Science in October 2022. The key terms used in the searches included "combined physical exercise and diet", "physical exercise, diet and gut microbiota", "physical exercise, diet and metabolic diseases" and "physical exercise, diet, gut microbiota and metabolic diseases".
Combined physical exercise and diet offer a more efficient approach for preventing metabolic diseases via the modification of gut microbiota, abating the burden related to longevity. Background: Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive research suggests that diet alongside physical exercise interventions exert beneficial effects on metabolic diseases by regulating gut microbiota, involving in the changes of the energy metabolism, immune regulation, and the microbial-derived metabolites. Objective: In this review, we present the latest evidence in the modulating role of diet and physical exercise in the gut microbiota and its relevance to metabolic diseases. We also summarize the research from animal and human studies on improving metabolic diseases through diet-plus-exercise interventions, and new targeted therapies that might provide a better understanding of the potential mechanisms. Methods: A systematic and comprehensive literature search was performed in PubMed/Medline and Web of Science in October 2022. The key terms used in the searches included “combined physical exercise and diet”, “physical exercise, diet and gut microbiota”, “physical exercise, diet and metabolic diseases” and “physical exercise, diet, gut microbiota and metabolic diseases”. Conclusions: Combined physical exercise and diet offer a more efficient approach for preventing metabolic diseases via the modification of gut microbiota, abating the burden related to longevity. BACKGROUNDUnhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive research suggests that diet alongside physical exercise interventions exert beneficial effects on metabolic diseases by regulating gut microbiota, involving in the changes of the energy metabolism, immune regulation, and the microbial-derived metabolites. OBJECTIVEIn this review, we present the latest evidence in the modulating role of diet and physical exercise in the gut microbiota and its relevance to metabolic diseases. We also summarize the research from animal and human studies on improving metabolic diseases through diet-plus-exercise interventions, and new targeted therapies that might provide a better understanding of the potential mechanisms. METHODSA systematic and comprehensive literature search was performed in PubMed/Medline and Web of Science in October 2022. The key terms used in the searches included "combined physical exercise and diet", "physical exercise, diet and gut microbiota", "physical exercise, diet and metabolic diseases" and "physical exercise, diet, gut microbiota and metabolic diseases". CONCLUSIONSCombined physical exercise and diet offer a more efficient approach for preventing metabolic diseases via the modification of gut microbiota, abating the burden related to longevity. |
Audience | Academic |
Author | Sun, Ying Zhang, Xin Liu, Yuan Zhang, Li |
AuthorAffiliation | 2 Department of Food Science and Engineering, Ningbo University, Ningbo 315211, China 1 Department of Physical Education, China University of Mining and Technology, Beijing 100083, China |
AuthorAffiliation_xml | – name: 2 Department of Food Science and Engineering, Ningbo University, Ningbo 315211, China – name: 1 Department of Physical Education, China University of Mining and Technology, Beijing 100083, China |
Author_xml | – sequence: 1 givenname: Li surname: Zhang fullname: Zhang, Li organization: Department of Physical Education, China University of Mining and Technology, Beijing 100083, China – sequence: 2 givenname: Yuan surname: Liu fullname: Liu, Yuan organization: Department of Physical Education, China University of Mining and Technology, Beijing 100083, China – sequence: 3 givenname: Ying surname: Sun fullname: Sun, Ying organization: Department of Food Science and Engineering, Ningbo University, Ningbo 315211, China – sequence: 4 givenname: Xin orcidid: 0000-0002-5795-9197 surname: Zhang fullname: Zhang, Xin organization: Department of Food Science and Engineering, Ningbo University, Ningbo 315211, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36432462$$D View this record in MEDLINE/PubMed |
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Snippet | Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut... Background: Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of... BACKGROUNDUnhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut... |
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SubjectTerms | Animals Blood pressure Body mass index Carbohydrates Care and treatment Cholesterol Cytokines Development and progression Diabetes Diet Dietary fiber Disease Diseases Ecosystem Energy metabolism Enzymes Exercise Gastrointestinal Microbiome - physiology Gastrointestinal system Glucose gut microbiota Health aspects Humans Hyperglycemia Hypertension Immune system Immunoregulation Inflammation Insulin Intestinal microflora Lipids Metabolic diseases Metabolic Diseases - prevention & control Metabolic disorders Metabolites Microbiota Microbiota (Symbiotic organisms) Microorganisms Nutrition research Permeability Physical exercise Physical fitness Physiological aspects Proteins Review Risk factors |
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Title | Combined Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat of Metabolic Disease: A Review |
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