Combined Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat of Metabolic Disease: A Review

Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive rese...

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Published inNutrients Vol. 14; no. 22; p. 4774
Main Authors Zhang, Li, Liu, Yuan, Sun, Ying, Zhang, Xin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.11.2022
MDPI
Subjects
Animals
Blood pressure
Body mass index
Carbohydrates
Care and treatment
Cholesterol
Cytokines
Development and progression
Diabetes
Diet
Dietary fiber
Disease
Diseases
Ecosystem
Energy metabolism
Enzymes
Exercise
Gastrointestinal Microbiome - physiology
Gastrointestinal system
Glucose
gut microbiota
Health aspects
Humans
Hyperglycemia
Hypertension
Immune system
Immunoregulation
Inflammation
Insulin
Intestinal microflora
Lipids
Metabolic diseases
Metabolic Diseases - prevention & control
Metabolic disorders
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Nutrition research
Permeability
Physical exercise
Physical fitness
Physiological aspects
Proteins
Review
Risk factors
China
diet
physical exercise
metabolic diseases
gut microbiota
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Abstract Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive research suggests that diet alongside physical exercise interventions exert beneficial effects on metabolic diseases by regulating gut microbiota, involving in the changes of the energy metabolism, immune regulation, and the microbial-derived metabolites. In this review, we present the latest evidence in the modulating role of diet and physical exercise in the gut microbiota and its relevance to metabolic diseases. We also summarize the research from animal and human studies on improving metabolic diseases through diet-plus-exercise interventions, and new targeted therapies that might provide a better understanding of the potential mechanisms. A systematic and comprehensive literature search was performed in PubMed/Medline and Web of Science in October 2022. The key terms used in the searches included "combined physical exercise and diet", "physical exercise, diet and gut microbiota", "physical exercise, diet and metabolic diseases" and "physical exercise, diet, gut microbiota and metabolic diseases". Combined physical exercise and diet offer a more efficient approach for preventing metabolic diseases via the modification of gut microbiota, abating the burden related to longevity.
AbstractList Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive research suggests that diet alongside physical exercise interventions exert beneficial effects on metabolic diseases by regulating gut microbiota, involving in the changes of the energy metabolism, immune regulation, and the microbial-derived metabolites. In this review, we present the latest evidence in the modulating role of diet and physical exercise in the gut microbiota and its relevance to metabolic diseases. We also summarize the research from animal and human studies on improving metabolic diseases through diet-plus-exercise interventions, and new targeted therapies that might provide a better understanding of the potential mechanisms. A systematic and comprehensive literature search was performed in PubMed/Medline and Web of Science in October 2022. The key terms used in the searches included "combined physical exercise and diet", "physical exercise, diet and gut microbiota", "physical exercise, diet and metabolic diseases" and "physical exercise, diet, gut microbiota and metabolic diseases". Combined physical exercise and diet offer a more efficient approach for preventing metabolic diseases via the modification of gut microbiota, abating the burden related to longevity.
Background: Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive research suggests that diet alongside physical exercise interventions exert beneficial effects on metabolic diseases by regulating gut microbiota, involving in the changes of the energy metabolism, immune regulation, and the microbial-derived metabolites. Objective: In this review, we present the latest evidence in the modulating role of diet and physical exercise in the gut microbiota and its relevance to metabolic diseases. We also summarize the research from animal and human studies on improving metabolic diseases through diet-plus-exercise interventions, and new targeted therapies that might provide a better understanding of the potential mechanisms. Methods: A systematic and comprehensive literature search was performed in PubMed/Medline and Web of Science in October 2022. The key terms used in the searches included “combined physical exercise and diet”, “physical exercise, diet and gut microbiota”, “physical exercise, diet and metabolic diseases” and “physical exercise, diet, gut microbiota and metabolic diseases”. Conclusions: Combined physical exercise and diet offer a more efficient approach for preventing metabolic diseases via the modification of gut microbiota, abating the burden related to longevity.
BACKGROUNDUnhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut microbiota architecture. The gut microbiota is a complicated and volatile ecosystem and can be regulated by diet and physical exercise. Extensive research suggests that diet alongside physical exercise interventions exert beneficial effects on metabolic diseases by regulating gut microbiota, involving in the changes of the energy metabolism, immune regulation, and the microbial-derived metabolites. OBJECTIVEIn this review, we present the latest evidence in the modulating role of diet and physical exercise in the gut microbiota and its relevance to metabolic diseases. We also summarize the research from animal and human studies on improving metabolic diseases through diet-plus-exercise interventions, and new targeted therapies that might provide a better understanding of the potential mechanisms. METHODSA systematic and comprehensive literature search was performed in PubMed/Medline and Web of Science in October 2022. The key terms used in the searches included "combined physical exercise and diet", "physical exercise, diet and gut microbiota", "physical exercise, diet and metabolic diseases" and "physical exercise, diet, gut microbiota and metabolic diseases". CONCLUSIONSCombined physical exercise and diet offer a more efficient approach for preventing metabolic diseases via the modification of gut microbiota, abating the burden related to longevity.
Audience Academic
Author Sun, Ying
Zhang, Xin
Liu, Yuan
Zhang, Li
AuthorAffiliation 2 Department of Food Science and Engineering, Ningbo University, Ningbo 315211, China
1 Department of Physical Education, China University of Mining and Technology, Beijing 100083, China
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Issue 22
Keywords diet
physical exercise
metabolic diseases
gut microbiota
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Snippet Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut...
Background: Unhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of...
BACKGROUNDUnhealthy diet and sedentary lifestyle have contributed to the rising incidence of metabolic diseases, which is also accompanied by the shifts of gut...
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SubjectTerms Animals
Blood pressure
Body mass index
Carbohydrates
Care and treatment
Cholesterol
Cytokines
Development and progression
Diabetes
Diet
Dietary fiber
Disease
Diseases
Ecosystem
Energy metabolism
Enzymes
Exercise
Gastrointestinal Microbiome - physiology
Gastrointestinal system
Glucose
gut microbiota
Health aspects
Humans
Hyperglycemia
Hypertension
Immune system
Immunoregulation
Inflammation
Insulin
Intestinal microflora
Lipids
Metabolic diseases
Metabolic Diseases - prevention & control
Metabolic disorders
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Nutrition research
Permeability
Physical exercise
Physical fitness
Physiological aspects
Proteins
Review
Risk factors
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Title Combined Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat of Metabolic Disease: A Review
URI https://www.ncbi.nlm.nih.gov/pubmed/36432462
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Volume 14
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