Matrix Metalloproteinases-1 and -8 Improve the Distribution and Efficacy of an Oncolytic Virus

• Published in: Cancer research (Chicago, Ill.) Vol. 67; no. 22; pp. 10664 - 10668
• Main Authors: Mok, Wilson, Boucher, Yves, Jain, Rakesh K.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.11.2007
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Biological Transport; Cell Line, Tumor; Gene Expression Regulation, Enzymologic; Gene Transfer Techniques; Genetic Therapy - methods; Glycosaminoglycans - metabolism; Herpes simplex virus; Humans; Matrix Metalloproteinase 1 - physiology; Matrix Metalloproteinase 8 - physiology; Medical sciences; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms - therapy; Oncolytic Viruses - genetics; Pharmacology. Drug treatments; Tumors; Peptidases; Enzyme; Treatment efficiency; Distribution; Hydrolases; Metalloendopeptidases; Oncolytic virus; Pharmacokinetics; Interstitial collagenase

Oncolytic viral vectors show enormous potential for the treatment of many solid tumors. However, these vectors often suffer from insufficient delivery within tumors, which limits their efficacy in both preclinical and clinical settings. We have previously shown that tumor collagen can significantly...