Multiple sclerosis in LRRK2 G2019S Parkinson’s disease and isolated nigral degeneration in a homozygous variant carrier

• Published in: Frontiers in neurology Vol. 15; p. 1450654
• Main Authors: Wise, Adina, Ortega, Roberto A., Raymond, Deborah, Cervera, Alessandra, Thorn, Emma, Leaver, Katherine, Russell, David S., Bressman, Susan B., Crary, John F., Saunders-Pullman, Rachel
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.08.2024
• Subjects: genetic; genetic risk; LRRK2; multiple sclerosis; Neurology; Parkinson’s disease; Parkinson’s genes; autoimmune diseases; genetic; LRRK2; Parkinson’s genes; multiple sclerosis; genetic risk; immunology & inflammation; Parkinson’s disease

variants have been associated with immune dysregulation as well as immune-related disorders such as IBD. A possible relationship between multiple sclerosis (MS) and PD has also been suggested. Further, neuropathologic studies of homozygous G2019S carriers with Parkinson's disease (PD) are rare,...